NCT07887880Not yet recruiting
A Novel Multimodal Approach to Promote Motor Recovery and Plasticity After Stroke
Source: ClinicalTrials.gov · Last updated 22 Oct 2026
Brief summary (registry, in English)
Upper extremity (UE) paresis or weakness is one of the most frequent impairments after stroke. Despite intense rehabilitation, motor and functional recovery of patients with severe hand impairments is poor. Hence, there is a need for more effective treatments to enhance motor function in patients with severe hand impairments after stroke. Adaptive functional electrical stimulation (FES) appears to be a promising treatment and has the potential to facilitate active movement in individuals with severe impairments post-stroke. In addition, transcranial random noise stimulation (trns) is a widely studied, non-invasive and safe method to enhance the corticomotor excitability in individuals with chronic stroke. However, the effect of combining trns and adaptive FES in patients with severe hand impairments has not been investigated. Therefore, the purpose of this study is to investigate whether combining trns with FES will enhance hand function in individuals with chronic stroke than FES alone. The investigators predict that combining trns with FES will significantly enhance hand function than FES alone.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 78 (estimated)
- First submitted
- 1 Jul 2026
- Start date
- 2 Nov 2026
- Primary completion date
- 1 Dec 2030
- Lead sponsor
- University of Utah
- Diseases
- Stroke
- NCT number
- NCT07887880
What you commit to
- Study type: Interventional
- Planned participants: 78
- From 2 Nov 2026 to the primary completion date, 1 Dec 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence of metallic implants in the head or neck
- Ferromagnetic metallic implants, pacemakers, other implanted devices, or ventilators (for MRI)
- Participation in concurrent occupational therapy
Other illness
- Diagnosis of neurological disorders other than stroke
- History of recent seizure or epilepsy while taking anticonvulsants
- Orthopedic/musculoskeletal conditions (e.g., arthritis) affecting the upper extremity
- Psychiatric diagnosis according to the criteria of the Diagnostic and Statistical Manual of Mental Disorder, Fifth Edition (DSM-V), or who are on psychotropic medication
Other
- A subject is not eligible for inclusion if any of the following criteria apply:
- Presence of severe aphasia preventing the ability to follow 1-step directions at least 80% of the time
- Excessive spasticity of the wrist and finger muscles, defined as a Modified Ashworth Score \>2
- Currently or planning to become pregnant
- Difficulty maintaining alertness or remaining still
- Bodyweight \> 300 lbs due to MRI scanner dimensions (for subjects also undergoing MRI)
Who the study is looking for
- Female and male subjects are eligible for inclusion only if all of the following criteria are met:
- Age between 40-85 years
- Diagnosis of first-ever subcortical stroke (single cerebrovascular accident)
- Stroke onset of at least six months prior to the time of participation
- Limited functional wrist and finger flexion and extension, as indicated between 5º-20º active movement
- Cognitive skills to actively participate, as indicated by scores of ≥ 24 on the Mini-Mental Status Examina-tion
- English speaking
Age in the registry: 40 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Utah Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.