NCT07888387Completed
Temporal Interference Stimulation in Major Depressive Disorder: A Pilot Feasibility Study
Modulating Emotional and Cognitive Circuits in Major Depressive Disorder Via Temporal Interference Stimulation
Source: ClinicalTrials.gov · Last updated 22 Oct 2026
Brief summary (registry, in English)
This pilot feasibility study used a randomized, double-blind, within-subject crossover design to explore temporal interference (TI) stimulation in adults with major depressive disorder. Fifteen participants received five weekly 20-minute stimulation sessions in randomized order, including TI stimulation targeting the left dorsolateral prefrontal cortex, left subgenual anterior cingulate cortex, right amygdala, and right ventral striatum, as well as a sham stimulation condition. The primary aim was to establish the feasibility of target-specific TI stimulation and to characterize its effects on functional connectivity and cognitive-emotional processing, assessed by resting-state fMRI and an emotional Stroop task before and after each session. Depressive and anxiety symptoms (HAMD and HAMA) were collected longitudinally across the five-week protocol as a secondary, exploratory measure.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 15 (actual)
- First submitted
- 27 Sept 2026
- Start date
- 25 Aug 2023
- Primary completion date
- 20 Mar 2024
- Lead sponsor
- Ruijin Hospital
- Diseases
- Depression
- NCT number
- NCT07888387
What you commit to
- Study type: Interventional
- Participants enrolled: 15
- From 25 Aug 2023 to the primary completion date, 20 Mar 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receipt of neurostimulation therapy within the previous 3 months.
Other illness
- History of other psychiatric disorders, such as schizophrenia or dementia, that in the investigator's judgment could affect the study results.
- History of neurological disorders, such as seizures.
- Presence of implants, including metallic foreign bodies in the skull or metallic cardiac implants.
Other
- High suicide risk as assessed by an experienced clinician.
- Pregnancy or breastfeeding.
Who the study is looking for
- Adults aged 18 to 65 years, male or female.
- Diagnosis of major depressive disorder (MDD) according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), made by an experienced clinician.
- Hamilton Depression Rating Scale-17 (HAMD-17) score of 17 or higher.
- No change in antidepressant medication regimen from 30 days before study participation and throughout the study.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ruijin hospital Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.