NCT07890376Not yet recruitingPhase 2
A Study to Investigate the Effect of LY4086940 Versus Placebo in Participants With Obesity or Overweight and Without Type 2 Diabetes
A Phase 2, Parallel-Group, Double-Blind Study to Investigate Weight Management With LY4086940 Compared With Placebo in Adult Participants With Obesity or Overweight and Without Type 2 Diabetes
Source: ClinicalTrials.gov · Last updated 3 Nov 2026
Brief summary (registry, in English)
The purpose of this study, performed under the master protocol W8M-MC- CWMM (NCT06143956), is to evaluate the efficacy and safety of LY4086940 compared with placebo in participants without type 2 diabetes who have obesity or who have overweight with a weight-related health condition. Participation in the study will last about 58 weeks.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 460 (estimated)
- First submitted
- 16 Oct 2026
- Start date
- Nov 2026
- Primary completion date
- Jan 2028
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT07890376
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 460
- From Nov 2026 to the primary completion date, Jan 2028
- 46 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have any prior diagnosis of type 2 diabetes, type 1 diabetes, or rare forms of diabetes mellitus, except gestational diabetes
- Have any of the following cardiovascular conditions within 6 months prior to screening:
- acute myocardial infarction
- cerebrovascular accident (stroke)
- unstable angina, or
- hospitalization due to congestive heart failure
- Within 6 months prior to screening, have taken medications (prescribed or over the counter) or alternative remedies (including herbal or nutritional supplements) that promote weight loss
Lab values
- Have a laboratory value suggestive of diabetes
Other
- In addition to exclusion criteria under Master Protocol CWMM (NCT06143956)
- Have a known personal or family history (first-degree relative) of multiple endocrine neoplasia type 2A or 2B, thyroid C-cell hyperplasia, or medullary thyroid carcinoma.
Who the study is looking for
- Meet inclusion criteria under Master Protocol CWMM (NCT06143956)
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (46)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Cicemo Srl Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Centro Médico Viamonte Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Mautalen Salud e Investigación Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| CARDIAMET Investigaciones Médicas Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Centro de Investigaciones Metabólicas (CINME) Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Instituto Médico Catamarca IMEC Coordinator of this site? Confirm its status | Rosario | Argentina | Unknown status |
| Dent Neurologic Institute Coordinator of this site? Confirm its status | Amherst | United States | Unknown status |
| Medical Research Partners Coordinator of this site? Confirm its status | Ammon | United States | Unknown status |
| IMA Clinical Research Austin Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| The Institute for Liver Health II dba Arizona Clinical Trials - Mesa Coordinator of this site? Confirm its status | Chandler | United States | Unknown status |
| Great Lakes Clinical Trials - Ravenswood Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| CTI Clinical Research Center Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| StudyMetrix Research Coordinator of this site? Confirm its status | City of Saint Peters | United States | Unknown status |
| Velocity Clinical Research, Dallas Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| FutureSearch Trials of Dallas Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Sovah Clinical Research-River District Coordinator of this site? Confirm its status | Danville | United States | Unknown status |
| NorCal Medical Research, Inc Coordinator of this site? Confirm its status | Greenbrae | United States | Unknown status |
| Tribe Clinical Research LLC Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Velocity Clinical Research-Huntington Park Coordinator of this site? Confirm its status | Huntington Park | United States | Unknown status |
| Las Vegas Medical Research Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| New Horizon Research Center Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Indago Research & Health Center, Inc Coordinator of this site? Confirm its status | Miami Lakes | United States | Unknown status |
| Monroe Biomedical Research Coordinator of this site? Confirm its status | Monroe | United States | Unknown status |
| Lucas Research, Inc. Coordinator of this site? Confirm its status | Morehead City | United States | Unknown status |
| Quality Medical Research Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| Knownwell Coordinator of this site? Confirm its status | Needham | United States | Unknown status |
| Lucida Clinical Trials Coordinator of this site? Confirm its status | New Bedford | United States | Unknown status |
| Lucas Research, Inc. Coordinator of this site? Confirm its status | New Bern | United States | Unknown status |
| Suncoast Clinical Research, Inc. Coordinator of this site? Confirm its status | New Port Richey | United States | Unknown status |
| Charter Research - Winter Park Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Rochester Clinical Research, LLC Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Peninsula Research Associates Coordinator of this site? Confirm its status | Rolling Hills Estates | United States | Unknown status |
| Endeavor Clinical Trials Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Headlands Research - Scottsdale Coordinator of this site? Confirm its status | Scottsdale | United States | Unknown status |
| Headlands Research - Detroit Coordinator of this site? Confirm its status | Southfield | United States | Unknown status |
| Clinvest Headlands LLC Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Stamford Therapeutics Consortium Coordinator of this site? Confirm its status | Stamford | United States | Unknown status |
| Charter Research - Lady Lake Coordinator of this site? Confirm its status | The Villages | United States | Unknown status |
| Cotton O'Neil Diabetes & Endocrinology Coordinator of this site? Confirm its status | Topeka | United States | Unknown status |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division Coordinator of this site? Confirm its status | Troy | United States | Unknown status |
| The Institute for Liver Health II dba Arizona Liver Health-Tucson Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
| Diablo Clinical Research, Inc. Coordinator of this site? Confirm its status | Walnut Creek | United States | Unknown status |
| Central Washington Health Services Association d/b/a Confluence Health Coordinator of this site? Confirm its status | Wenatchee | United States | Unknown status |
| Texas Valley Clinical Research Coordinator of this site? Confirm its status | Weslaco | United States | Unknown status |
| Iowa Diabetes and Endocrinology Research Center Coordinator of this site? Confirm its status | West Des Moines | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.