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NCT07890376Not yet recruitingPhase 2

A Study to Investigate the Effect of LY4086940 Versus Placebo in Participants With Obesity or Overweight and Without Type 2 Diabetes

A Phase 2, Parallel-Group, Double-Blind Study to Investigate Weight Management With LY4086940 Compared With Placebo in Adult Participants With Obesity or Overweight and Without Type 2 Diabetes

Source: ClinicalTrials.gov · Last updated 3 Nov 2026

Brief summary (registry, in English)

The purpose of this study, performed under the master protocol W8M-MC- CWMM (NCT06143956), is to evaluate the efficacy and safety of LY4086940 compared with placebo in participants without type 2 diabetes who have obesity or who have overweight with a weight-related health condition. Participation in the study will last about 58 weeks.

Status (registry)
Not yet recruiting
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
460 (estimated)
First submitted
16 Oct 2026
Start date
Nov 2026
Primary completion date
Jan 2028
Lead sponsor
Eli Lilly and Company
NCT number
NCT07890376

What you commit to

  • Study type: Interventional · Phase 2
  • Planned participants: 460
  • From Nov 2026 to the primary completion date, Jan 2028
  • 46 sites in 2 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study design.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Have any prior diagnosis of type 2 diabetes, type 1 diabetes, or rare forms of diabetes mellitus, except gestational diabetes
  • Have any of the following cardiovascular conditions within 6 months prior to screening:
    • acute myocardial infarction
    • cerebrovascular accident (stroke)
    • unstable angina, or
    • hospitalization due to congestive heart failure
  • Within 6 months prior to screening, have taken medications (prescribed or over the counter) or alternative remedies (including herbal or nutritional supplements) that promote weight loss

Lab values

  • Have a laboratory value suggestive of diabetes

Other

  • In addition to exclusion criteria under Master Protocol CWMM (NCT06143956)
  • Have a known personal or family history (first-degree relative) of multiple endocrine neoplasia type 2A or 2B, thyroid C-cell hyperplasia, or medullary thyroid carcinoma.

Who the study is looking for

  • Meet inclusion criteria under Master Protocol CWMM (NCT06143956)

Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (46)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
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Buenos AiresArgentinaUnknown status
Cicemo Srl
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Buenos AiresArgentinaUnknown status
Centro Médico Viamonte
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Buenos AiresArgentinaUnknown status
Mautalen Salud e Investigación
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Buenos AiresArgentinaUnknown status
CARDIAMET Investigaciones Médicas
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Buenos AiresArgentinaUnknown status
Centro de Investigaciones Metabólicas (CINME)
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Buenos AiresArgentinaUnknown status
Instituto Médico Catamarca IMEC
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RosarioArgentinaUnknown status
Dent Neurologic Institute
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AmherstUnited StatesUnknown status
Medical Research Partners
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AmmonUnited StatesUnknown status
IMA Clinical Research Austin
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AustinUnited StatesUnknown status
The Institute for Liver Health II dba Arizona Clinical Trials - Mesa
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ChandlerUnited StatesUnknown status
Great Lakes Clinical Trials - Ravenswood
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ChicagoUnited StatesUnknown status
CTI Clinical Research Center
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CincinnatiUnited StatesUnknown status
StudyMetrix Research
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City of Saint PetersUnited StatesUnknown status
Velocity Clinical Research, Dallas
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DallasUnited StatesUnknown status
FutureSearch Trials of Dallas
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DallasUnited StatesUnknown status
Sovah Clinical Research-River District
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DanvilleUnited StatesUnknown status
NorCal Medical Research, Inc
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GreenbraeUnited StatesUnknown status
Tribe Clinical Research LLC
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GreenvilleUnited StatesUnknown status
Velocity Clinical Research-Huntington Park
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Huntington ParkUnited StatesUnknown status
Las Vegas Medical Research
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Las VegasUnited StatesUnknown status
New Horizon Research Center
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MiamiUnited StatesUnknown status
Indago Research & Health Center, Inc
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Miami LakesUnited StatesUnknown status
Monroe Biomedical Research
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MonroeUnited StatesUnknown status
Lucas Research, Inc.
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Morehead CityUnited StatesUnknown status
Quality Medical Research
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NashvilleUnited StatesUnknown status
Knownwell
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NeedhamUnited StatesUnknown status
Lucida Clinical Trials
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New BedfordUnited StatesUnknown status
Lucas Research, Inc.
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New BernUnited StatesUnknown status
Suncoast Clinical Research, Inc.
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New Port RicheyUnited StatesUnknown status
Charter Research - Winter Park
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OrlandoUnited StatesUnknown status
Rochester Clinical Research, LLC
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RochesterUnited StatesUnknown status
Peninsula Research Associates
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Rolling Hills EstatesUnited StatesUnknown status
Endeavor Clinical Trials
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San AntonioUnited StatesUnknown status
Headlands Research - Scottsdale
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ScottsdaleUnited StatesUnknown status
Headlands Research - Detroit
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SouthfieldUnited StatesUnknown status
Clinvest Headlands LLC
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SpringfieldUnited StatesUnknown status
Stamford Therapeutics Consortium
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StamfordUnited StatesUnknown status
Charter Research - Lady Lake
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The VillagesUnited StatesUnknown status
Cotton O'Neil Diabetes & Endocrinology
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TopekaUnited StatesUnknown status
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
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TroyUnited StatesUnknown status
The Institute for Liver Health II dba Arizona Liver Health-Tucson
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TucsonUnited StatesUnknown status
Diablo Clinical Research, Inc.
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Walnut CreekUnited StatesUnknown status
Central Washington Health Services Association d/b/a Confluence Health
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WenatcheeUnited StatesUnknown status
Texas Valley Clinical Research
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WeslacoUnited StatesUnknown status
Iowa Diabetes and Endocrinology Research Center
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West Des MoinesUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.