NCT07891624Recruiting
Neural Mechanisms of Real-world Emotions and Internalizing
Using High-stakes, Real-world Events to Map the Neural Dynamics Linked to Internalizing Disorders
Source: ClinicalTrials.gov · Last updated 23 Oct 2026
Brief summary (registry, in English)
This study utilizes mobile health methods, including smartphone technology, subjective self-reports measures of emotion, behavioral tasks, functional Magnetic Resonance Imaging (fMRI), physiological measures of attention and arousal, and measures of health and social support to identify neural mechanisms associated with individual differences in the temporal course of emotional responses. The aim of this project is to utilize real-world and personally relevant events as stimuli to better understand how the temporal course of emotional responses relate to risk for developing mental disorders.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 144 (estimated)
- First submitted
- 16 Oct 2026
- Start date
- 24 Aug 2026
- Primary completion date
- 30 Nov 2030
- Lead sponsor
- University of Miami
- Diseases
- Depression
- NCT number
- NCT07891624
What you commit to
- Study type: Interventional
- Planned participants: 144
- From 24 Aug 2026 to the primary completion date, 30 Nov 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Women who are pregnant or breast feeding and are no more than six months post-partum. \[Reason: may be unsafe for fetus, may affect outcome measure(s)\]
- Individuals who are excluded based on attached metal resonance Screening Form (Note: this form has already been approved by the Institutional Review Board (IRB for other protocols). \[Reason: necessary to participate in MRI research protocol\]
- Individuals whose BMI is above 35. \[Reason: must fit into fMRI scanner\]
- Individuals who have claustrophobia. \[Reason: to be able to stay in MRI scanner\]
- Individuals who are unable, in the judgment of the investigator, to comply with directions and/or tolerate the procedures required for participation in this trial. \[Reason: to be able to understand instructions and ensure safety\]
- Individuals who are unable to safely undergo MRI scanning. \[Reason: to be able to undergo MRI scanning\]
Who the study is looking for
- Individuals who are between 18 - 35 years old. \[Reason: to be able to provide informed consent, and to minimize variation in functional and structural differences in brain\]
- Individuals who are fluent English speakers. \[Reason: to understand study instructions \& questionnaires\]
- Smart phone access. \[Reason: to answer the questionnaires that are administered throughout the study.
Age in the registry: 18 years to 35 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Miami Coordinator of this site? Confirm its status | Coral Gables | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.