NCT07892287Not yet recruiting
Effect of Neurofeedback and TMS
Pilot Study of Synergistic Effects of rTMS and Neurofeedback in Major Depressive Disorder
Source: ClinicalTrials.gov · Last updated 23 Oct 2026
Brief summary (registry, in English)
The goal of this clinical trial is to is to learn whether adding EEG neurofeedback (NFB) to repetitive transcranial magnetic stimulation (rTMS) is safe and feasible for adults with major depressive disorder (MDD). The study will also explore whether combining NFB with TMS may improve depression symptoms and change brain activity related to mood, focus, and rumination. The main questions it aims to answer are: * Is alpha-down neurofeedback safe, tolerable, and feasible for people with MDD? * Does alpha-down neurofeedback improve symptoms of depression, anxiety, and difficulties with attention, emotion regulation, and rumination? * Does combining neurofeedback with TMS produce greater changes in symptoms than either treatment alone? Researchers will compare 3 groups (TMS only, neurofeedback only, and TMS combined with neurofeedback) to see if combining neurofeedback with TMS will produce greater changes in symptoms than either treatment alone. Participants will: * Complete assessments of depression severity, anxiety, and cognitive function. * Complete 5 treatment sessions Monday through Friday. * Receive alpha-down neurofeedback, TMS, or both, depending on their group assignment. * Complete EEG recordings of brain activity before and after treatment. * Complete a questionnaire about their experience in the study.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 16 Sept 2026
- Start date
- 1 Jan 2027
- Primary completion date
- 31 Jan 2027
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Depression
- NCT number
- NCT07892287
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 1 Jan 2027 to the primary completion date, 31 Jan 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Have ever been diagnosed with bipolar disorder, psychosis, autism spectrum disorder, or another neurodevelopmental disorder.
- Have ever had a seizure or been diagnosed with epilepsy.
Other
- Current major depressive episode with suicidal thoughts.
- Have had a significant head injury that resulted in prolonged loss of consciousness, ongoing neurological problems, or a known structural brain abnormality.
- Are currently intoxicated, experiencing substance withdrawal, or have an unstable pattern of substance use that could make participation unsafe or interfere with the study procedures.
- Are pregnant or think you may be pregnant.
Who the study is looking for
- Be between 18 and 65 years old.
- Have a diagnosis of Major Depressive Disorder (MDD), confirmed using standard diagnostic criteria.
- Have normal hearing and normal or corrected-to-normal vision.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.