NCT07893249Not yet recruiting
Individual Variability in Energy Compensation After a 12-Week Supervised Exercise Intervention
Personal Healthcare: Maxmising the Benefits of Exercise by Understanding the Mechanisms of Metabolic Compensation
Source: ClinicalTrials.gov · Last updated 23 Oct 2026
Brief summary (registry, in English)
This prospective, single-arm interventional study will investigate why adults receiving the same prescribed dose and relative intensity of exercise show divergent changes in energy balance, body weight, and body composition. A total of 150 sedentary Chinese adults aged 18-40 years with overweight or obesity will complete a 12-week, supervised treadmill exercise programme. Exercise will be performed five times per week at an intensity corresponding to 60% of each participant's measured maximal oxygen uptake. Prescribed exercise energy expenditure will increase progressively from 150 kcal per session in Weeks 1-4 to 250 kcal per session in Weeks 5-8 and 350 kcal per session in Weeks 9-12. The primary objective is to quantify inter-individual variability in energy compensation after the standardized intervention. Detailed measurements will characterize total and resting energy expenditure, energy intake, appetite, physical activity, body composition, glucose dynamics, cardiorespiratory fitness, brain responses to food-related stimuli, and molecular phenotypes. Multi-omics analyses will include gut microbiome, metabolomic, proteomic, extracellular-vesicle, peripheral blood mononuclear cell, and transcriptomic assessments. The study will explore physiological, behavioral, and molecular factors associated with divergent compensatory responses. No randomized comparator group is included; therefore, causal comparisons between exercise and non-exercise conditions are outside the study scope.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- First submitted
- 25 Sept 2026
- Start date
- 25 Oct 2026
- Primary completion date
- 31 Dec 2029
- Lead sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
- Diseases
- Obesity
- NCT number
- NCT07893249
What you commit to
- Study type: Interventional
- Planned participants: 150
- From 25 Oct 2026 to the primary completion date, 31 Dec 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Individuals who have undergone major surgery within the past 6 months (tooth extraction excluded);
- Individuals with claustrophobia or metallic implants in the body which are incompatible with MRI measurements
Other illness
- Individuals with cardiovascular diseases (e.g., hypertension) and severe
- metabolic diseases requiring continuous medication (e.g., diabetes);
- Exercise-induced injuries, including joint diseases, fractures, etc.;
- Individuals with infectious diseases, such as HIV/AIDS, tuberculosis, malaria, etc.;
- Psychiatric and neurological disorders, such as anorexia nervosa, etc.;
- Individuals with a history of hemophobia or needle phobia.
Other
- Individuals who have attempted weight loss or weight gain through various means within the past three months;
- Individuals who are pregnant, breastfeeding, or planning to become pregnant during the study period
- Individuals who have used antibiotics, probiotics, oral laxatives, etc., within eight weeks;
- Individuals who have been drinking deuterium depleted water which is incompatible with the DLW measures.
Who the study is looking for
- Sedentary individuals
- BMI ≥ 24 kg/m2
- Chinese male and female adults
- Normal electrocardiogram (ECG)
Age in the registry: 18 years to 40 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences Coordinator of this site? Confirm its status | Shenzhen | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.