NCT07896642Recruiting
Brown Adipose Tissue Modulation in Polycystic Ovary Syndrome Using Infrared Thermography
Investigation of Brown Adipose Tissue Modulation in Polycystic Ovary Syndrome Using Infrared Thermography
Source: ClinicalTrials.gov · Last updated 27 Oct 2026
Brief summary (registry, in English)
This study will investigate brown adipose tissue-related physiological responses in women with polycystic ovary syndrome (PCOS). Women with PCOS who have normal body mass index, women with PCOS who are overweight or have obesity, and healthy women will be compared. Brown adipose tissue-related heat responses will be evaluated using non-invasive infrared thermography of the supraclavicular region, together with serum UCP-1 levels and metabolic measurements. Participants in the overweight/obesity PCOS group will receive an inositol supplement for 12 weeks, and measurements will be repeated after supplementation. The study will also examine possible relationships between surface temperature responses, dietary intake, physical activity, body measurements, and metabolic and hormonal markers.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 8 Oct 2026
- Start date
- 1 Sept 2026
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Istanbul Health and Technology University
- NCT number
- NCT07896642
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 1 Sept 2026 to the primary completion date, 31 Dec 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Being highly physically active, defined as regular exercise during the previous 6 months or being a professional athlete
- Any intervention for PCOS treatment within the previous 6 months, including pharmacological treatment or alternative approaches such as acupuncture
- Regular medication use within the previous 3 months or currently, particularly oral contraceptives, hormonal medications, or medications affecting metabolism
Other illness
- Presence of endocrine disorders that may affect the diagnosis of PCOS, including thyroid disease, congenital adrenal hyperplasia, androgen-secreting tumors, or Cushing syndrome
- History of ovarian surgery
- Presence of any of the following conditions:
- Secondary hypertension
- Cardiovascular, cerebrovascular, renal, hepatic, thyroid, or pulmonary disease
- Any type of cancer
- Acute infection
- Autoimmune disease
- Severe psychological or neurological disease
- History of obesity-specific treatment, including bariatric surgery or anti-obesity medication
Age
- Age ≤17 years or ≥41 years
Other
- Male sex
- Menopausal status
- BMI \<18.5 kg/m²
- Pregnancy or breastfeeding
- Regular smoking or alcohol consumption
- Following a special diet that may affect metabolic rate, including vegetarian, vegan, diabetic, or low-calorie diets
- Regular use of dietary supplements such as probiotics or prebiotics
Who the study is looking for
- Female participants aged 18-40 years
- Premenopausal status
- Ability and willingness to provide written informed consent
- For the Overweight/Obesity PCOS - Inositol and Normal-BMI PCOS Reference Group arms:
- Diagnosis of polycystic ovary syndrome (PCOS) established by an obstetrician and gynecologist according to the Rotterdam criteria
- For the Normal-BMI PCOS Reference Group arm:
- BMI 18.5-24.9 kg/m²
- For the Overweight/Obesity PCOS - Inositol arm:
- BMI ≥25 kg/m²
- For the Healthy Control Group arm:
- BMI 18.5-24.9 kg/m²
- Regular menstrual cycles
- Normal ovarian morphology
- No diagnosis of PCOS
Age in the registry: 18 years to 40 years · Sex: Female · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Istanbul Health and Technology University Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Recruiting |
| Bezmialem Vakif University Faculty of Medicine Hospital Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.