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NCT07898397Recruiting

Long-Term Epilepsy Outcomes in Children With a History of Perinatal Stroke

Source: ClinicalTrials.gov · Last updated 27 Oct 2026

Brief summary (registry, in English)

Perinatal stroke is a rare condition affecting approximately 20-40 births per 100,000. It may be ischemic or hemorrhagic and can occur before or around birth, with diagnosis sometimes delayed until motor or cognitive symptoms emerge. Potential long-term consequences include motor deficits, cognitive and learning difficulties, language disorders, and epilepsy. Post-stroke epilepsy is estimated to affect approximately 30% of children who experience perinatal stroke. Although neonatal outcomes are relatively well characterized, the long-term course of epilepsy in this population and the relationship between initial stroke characteristics and subsequent epilepsy outcomes remain insufficiently studied. The primary objective of this retrospective, multicenter, observational study is to characterize the long-term course of epilepsy in children who experienced an ischemic or hemorrhagic stroke before 28 days of age.

Status (registry)
Recruiting
Study type
Observational
Enrollment
120 (estimated)
First submitted
20 Oct 2026
Start date
28 Apr 2026
Primary completion date
28 Feb 2027
Lead sponsor
University Hospital, Strasbourg, France
Diseases
Epilepsy, Stroke
NCT number
NCT07898397

What you commit to

  • Study type: Observational
  • Planned participants: 120
  • From 28 Apr 2026 to the primary completion date, 28 Feb 2027
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other

  • Birth before 34 weeks of gestation.
  • Birth weight below 1,500 g.
  • Perinatal hypoxic-ischemic injury with residual MRI lesions.
  • Insufficient information in medical records.
  • Refusal to participate in the study.

Who the study is looking for

  • Minors aged 5 to under 18 years or adults aged 18 to 25 years.
  • Patients who attended one of the two participating centers: Strasbourg University Hospitals or Necker Hospital (AP-HP).
  • Confirmed or suspected ischemic or hemorrhagic stroke occurring before 28 days of age.
  • During follow-up, presentation of criteria for focal epilepsy, infantile spasms, continuous spike-and-wave during sleep (CSWS), or Lennox-Gastaut syndrome.

Age in the registry: 5 years to 25 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Service de Pédiatrie 1 - Hôpital de Hautepierre - CHU de Strasbourg, France
Coordinator of this site? Confirm its status
StrasbourgFranceRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.