NCT07898709Not yet recruitingPhase 2
Evaluating SGLT2 Inhibitors for the Reduction of No-Reflow Phenomenon in Patients Undergoing PCI
Evaluation of Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors Administration as Adjunctive Therapies for the Reduction of the No-reflow Phenomenon in Patients With Myocardial Infarction Undergoing Percutaneous Coronary Intervention (PCI): A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 27 Oct 2026
Brief summary (registry, in English)
Study Background \& Purpose: The no-reflow phenomenon is a significant complication occurring in patients with acute myocardial infarction who undergo percutaneous coronary intervention (PCI). It leads to poor myocardial perfusion despite successful opening of the culprit coronary artery. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have demonstrated cardioprotective mechanisms beyond glucose control. Objective: This randomized controlled trial aims to evaluate the effectiveness and safety of administering SGLT2 inhibitors as adjunctive therapy in reducing the incidence of the no-reflow phenomenon in patients with myocardial infarction undergoing PCI. Study Plan: Eligible patients presenting with myocardial infarction scheduled for PCI will be randomized into three groups: one group receiving standard pharmacological care plus Empagliflozin therapy, second group receiving standard pharmacological care plus dapagliflozin therapy, and the control group receiving standard pharmacological care alone. Patients will be monitored during and after the procedure to evaluate coronary blood flow and incidence of no reflow phenomenon.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 16 Oct 2026
- Start date
- Jan 2027
- Primary completion date
- Jun 2027
- Lead sponsor
- Al-Azhar University
- Diseases
- Coronary artery disease
- NCT number
- NCT07898709
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 100
- From Jan 2027 to the primary completion date, Jun 2027
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Ongoing treatment with SGLT2 inhibitors.
- Current Participation in another clinical trial or having participated in the week prior to recruitment
Other illness
- History of coronary artery bypass graft surgery.
- Known allergy to SGLT2 inhibitors.
- Severe hepatic impairment.
- Type 1 diabetes mellitus or history of diabetic ketoacidosis.
- Active infection or recurrent urinary/genital infections.
Age
- Severe dehydration or clinical condition predisposing to volume depletion.
- For women of childbearing age:
Other
- Patients meeting any of the following criteria will be excluded:
- Hemodynamically unstable patients(systolic blood pressure \<90 mmHg or mean arterialpressure \< 60 mmHg).
- Acute kidney injury or estimated glomerular filtration rate \<30 mL/min/1.73 m².
- Current or planned pregnancy or lactation.
Who the study is looking for
- Adult male or female patients aged 18-75 years.
- Confirmed acute myocardial infarction.
- Will undergo percutaneous coronary intervention (PCI).
- Ability to receive the study medication before PCI without delaying the clinically indicated procedure.
- Ability and willingness to provide written informed consent and comply with the study protocol.
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sayed Galal University Hospital Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
| Islamic Cardiac Surgery Center , Al-Azhar University Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
| Al-Hussein University Hospital Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
| Al-Zahraa University Hospital Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.