NCT07902596Not yet recruiting
Lymph Node Dissection After Neoadjuvant Therapy for Gastric and EGJ Adenocarcinoma
Optimizing the Extent of Lymph Node Dissection After Neoadjuvant Therapy for Gastric and Esophagogastric Junction Adenocarcinoma: A Multicenter Retrospective Cohort Study
Source: ClinicalTrials.gov · Last updated 29 Oct 2026
Brief summary (registry, in English)
This multicenter retrospective observational cohort study will evaluate approximately 2,000 adults with gastric or esophagogastric junction adenocarcinoma who received at least two cycles of neoadjuvant therapy followed by R0 gastrectomy with lymph node dissection. The study will estimate the frequency of pathological metastasis at individual lymph node stations according to the final preoperative imaging-based ycT and ycN categories and tumor location. The findings are intended to provide evidence for future prospective studies of risk-adapted reduction of perigastric lymph node dissection. No treatment is assigned by this study.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 2000 (estimated)
- First submitted
- 22 Oct 2026
- Start date
- 25 Oct 2026
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- The First Affiliated Hospital with Nanjing Medical University
- Diseases
- Gastric and esophageal cancer
- NCT number
- NCT07902596
What you commit to
- Study type: Observational
- Planned participants: 2000
- From 25 Oct 2026 to the primary completion date, 31 Dec 2026
- 8 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- R1 or R2 resection, palliative surgery, or exploratory surgery without curative gastrectomy.
- Previous gastrectomy.
Other illness
- Conversion therapy for initially unresectable or metastatic disease.
- ycM1 disease, including peritoneal, hepatic, or other distant metastasis.
- Synchronous multiple primary gastric cancers.
- Another active malignant tumor.
Other
- Histological diagnosis other than adenocarcinoma, including squamous cell carcinoma, lymphoma, gastrointestinal stromal tumor, or neuroendocrine neoplasm.
- Intraperitoneal hyperthermic perfusion treatment.
- Missing core data required for eligibility or the primary analysis, including ycT, ycN, gastrectomy type, or station-specific pathological records.
Who the study is looking for
- Age 18 years or older.
- Histologically confirmed gastric adenocarcinoma or esophagogastric junction adenocarcinoma.
- Completion of at least two cycles of neoadjuvant chemotherapy, chemotherapy combined with immunotherapy, or chemoradiotherapy.
- Final preoperative imaging assessment within four weeks before surgery with evaluable ycT and ycN categories according to the AJCC/UICC eighth edition.
- ycM0 disease before surgery.
- R0 curative-intent total, distal, or proximal gastrectomy with lymph node dissection.
- Identifiable surgical procedure and evaluable station-specific lymph node pathological records.
- Surgery performed between January 1, 2021, and August 30, 2026.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (8)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First People's Hospital of Lianyungang Coordinator of this site? Confirm its status | Lianyungang | China | Unknown status |
| The First Affiliated Hospital with Nanjing Medical University Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
| Jiangsu Cancer Hospital Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
| Affiliated Drum Tower Hospital, Medical School of Nanjing University Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
| The Affiliated Hospital of Qingdao University Coordinator of this site? Confirm its status | Qingdao | China | Unknown status |
| Fudan University Shanghai Cancer Center Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| The Fourth Hospital of Hebei Medical University Coordinator of this site? Confirm its status | Shijiazhuang | China | Unknown status |
| The First Affiliated Hospital of Soochow University Coordinator of this site? Confirm its status | Suzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.