NCT07905209Active, not recruiting
Evaluation of MTHFR and DNMT3B Gene Polymorphisms Along With Periodontal Clinical Parameters in Healthy Individuals and Individuals With Type 2 Diabetes and Periodontitis
Source: ClinicalTrials.gov · Last updated 29 Oct 2026
Brief summary (registry, in English)
Periodontitis is a chronic inflammatory disease that affects the tissues supporting the teeth and can lead to progressive tissue destruction. Type 2 diabetes mellitus is a metabolic disease characterized by persistently elevated blood glucose levels. These two conditions are closely related, and genetic factors may influence their development and severity. This observational study aims to evaluate the distribution of methylenetetrahydrofolate reductase (MTHFR) and DNA methyltransferase 3B (DNMT3B) gene polymorphisms in healthy individuals, individuals with periodontitis, individuals with type 2 diabetes mellitus, and individuals with both conditions. The study also aims to investigate the associations between these genetic variations and periodontal clinical parameters. The study includes 200 participants divided into four groups of 50 individuals each: healthy individuals, individuals with type 2 diabetes without periodontitis, individuals with periodontitis without type 2 diabetes, and individuals with both type 2 diabetes and periodontitis. Periodontal examinations include the assessment of plaque index, gingival index, probing pocket depth, clinical attachment loss, and gingival recession. Venous blood samples are collected for molecular analysis of MTHFR and DNMT3B gene polymorphisms. The findings may contribute to a better understanding of the potential role of genetic factors in periodontal disease and its relationship with type 2 diabetes mellitus.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 200 (actual)
- First submitted
- 20 Oct 2026
- Start date
- 2 Apr 2026
- Primary completion date
- 2 Aug 2026
- Lead sponsor
- Akdeniz University
- Diseases
- Type 2 diabetes
- NCT number
- NCT07905209
What you commit to
- Study type: Observational
- Participants enrolled: 200
- From 2 Apr 2026 to the primary completion date, 2 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Individuals who have received periodontal treatment within the last 6 months.
Other illness
- Individuals with systemic diseases known to affect periodontal health other than diabetes mellitus (e.g., hypertension, cardiovascular diseases).
- Individuals with infectious diseases such as tuberculosis, hepatitis, or AIDS.
Age
- Individuals under 18 years of age.
Other
- Current smokers.
- Pregnant women.
- Individuals who refuse to participate in the study or do not provide informed consent.
Who the study is looking for
- Being a non-smoker.
- Having received no periodontal treatment within the last 6 months.
- Having no systemic disease known to affect periodontal health other than diabetes mellitus (e.g., hypertension, cardiovascular diseases).
- Having no infectious diseases such as tuberculosis, hepatitis, or AIDS.
- Being 18 years of age or older.
- Not being pregnant (for female participants).
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Akdeniz University Faculty of Dentistry, Department of Periodontology Coordinator of this site? Confirm its status | Antalya | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.