NCT07905898Not yet recruiting
Evaluating and Promoting Resilience in Adolescents With Tourette Syndrome
Adapting and Pilot Testing Promoting Resilience in Stress Management (PRISM) for Adolescents With Tourette Syndrome and Persistent Tic Disorders: A Mixed-Methods Feasibility Study and Pilot Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 30 Oct 2026
Brief summary (registry, in English)
This study adapts and tests PRISM (Promoting Resilience in Stress Management), a short skills-based program that teaches resilience, for teens ages 12-18 with Tourette syndrome or persistent tic disorder. The study has three parts. First, a small group of teens and their caregivers try PRISM and give feedback to adapt it for teens with tics. Second, 15 teens complete the adapted program to see whether it is practical and acceptable. Third, 60 teens are randomly assigned to PRISM plus usual care or usual care alone, to see whether a larger trial is feasible and to get early information on resilience and other outcomes.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 95 (estimated)
- First submitted
- 23 Oct 2026
- Start date
- Nov 2026
- Primary completion date
- Mar 2031
- Lead sponsor
- Wake Forest University Health Sciences
- NCT number
- NCT07905898
What you commit to
- Study type: Interventional
- Planned participants: 95
- From Nov 2026 to the primary completion date, Mar 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Beginning any new therapy within 8 weeks of study initiation
Other illness
- An active diagnosis of functional neurological disorder
Who the study is looking for
- Age 12-18 years
- Physician-confirmed diagnosis of Tourette syndrome or persistent (chronic) motor or vocal tic disorder per DSM-5-TR criteria
- YGTSS Total Tic Severity ≥15 (Tourette syndrome) or Total Motor/Total Phonic score ≥10 (persistent motor or vocal tic disorder)
- YGTSS Impairment ≥20
- English fluency in reading and speaking, even as a second language
- Able to understand and complete study procedures and measures
Age in the registry: 12 years to 18 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Atrium Health Wake Forest Baptist Coordinator of this site? Confirm its status | Winston-Salem | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.