NCT07910968Not yet recruiting
SWitching to Appropriate Prescription in Cardiovascular-Kidney-Metabolic Syndrome
Source: ClinicalTrials.gov · Last updated 2 Nov 2026
Brief summary (registry, in English)
SWAP-CKM (SWitching to Appropriate Prescription in Cardiovascular-Kidney-Metabolic Syndrome) is a pragmatic, cluster-randomized clinical trial designed to evaluate whether electronic health record (EHR)-based alerts can improve medication prescribing among adults with cardiovascular, kidney, and metabolic (CKM) conditions. The study will include all eligible adult patients receiving care within Kaiser Permanente Northern California (KPNC) who have CKM conditions and opportunities for therapeutic medication substitution. Fifteen service areas are randomly assigned to either an intervention group or a usual care group. Clinicians in the intervention group will receive EHR-based Best Practice Advisories (BPAs) identifying opportunities to replace potentially inappropriate medications with guideline-recommended therapies. The intervention may also include audit-and-feedback reports to support medication optimization. Clinicians retain full discretion over treatment decisions. The primary outcome is the proportion of eligible therapeutic optimization opportunities achieved at 9 months. Secondary outcomes include medication initiation and discontinuation, medication optimization at 18 months, and polypharmacy burden.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 1200 (estimated)
- First submitted
- 27 Oct 2026
- Start date
- 4 Nov 2026
- Primary completion date
- 4 Aug 2027
- Lead sponsor
- Kaiser Permanente
- NCT number
- NCT07910968
What you commit to
- Study type: Interventional
- Planned participants: 1200
- From 4 Nov 2026 to the primary completion date, 4 Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently on dialysis
- Receiving hospice care
- Prior history of LVAD, heart transplantation, or any solid organ transplantation
Other
- Membership at KPNC \< 6 months
Who the study is looking for
- Age \>=18 years
- Presence of appropriate CKM condition
- Eligible for at least one therapeutic swap
- Outpatient encounter, including in-person or telehealth care, with an eligible clinician during the study period.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kaiser Permenante Division of Research Coordinator of this site? Confirm its status | Pleasanton | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.