NCT07912190Recruiting
ePRO in Advanced Lung Cancer: Emotional Distress, Symptom Burden, Brain Metastasis
A Study on the Correlation of Emotional Distress and Symptom Burden With Brain Metastasis Status in Patients With Advanced Lung Cancer Based on Electronic Patient-reported Outcomes
Source: ClinicalTrials.gov · Last updated 3 Nov 2026
Brief summary (registry, in English)
This study intends to adopt a prospective longitudinal research design to comprehensively evaluate patient-reported emotional stress and symptom burden in patients with advanced lung cancer and lung cancer brain metastasis during first-line and maintenance treatment, extract symptom clusters, and describe the longitudinal dynamic trajectories of symptoms and symptom clusters over time. Meanwhile, it analyzes the relationships between brain metastasis and emotional stress as well as symptom trajectories. Patients will be divided into three cohorts according to the status of brain metastasis: non-metastasis, stable brain metastasis, and progressive brain metastasis. Differences in emotional stress, symptom burden and symptom cluster manifestations among subgroups will be further compared, together with their correlations with brain metastasis. This study aims to improve the understanding of the characteristics of symptom burden and symptom cluster profiles mediated by emotional stress in lung cancer patients throughout treatment.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 27 Oct 2026
- Start date
- 4 Jan 2026
- Primary completion date
- 31 Oct 2026
- Lead sponsor
- Qian Chu
- Diseases
- Lung cancer
- NCT number
- NCT07912190
What you commit to
- Study type: Observational
- Planned participants: 200
- From 4 Jan 2026 to the primary completion date, 31 Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior receipt of anti-tumor treatment;
Other illness
- Complicated with severe chronic diseases of the heart, liver, kidney and other vital organs;
- A previous medical history of other malignant tumors.
Other
- Abnormal consciousness or mental status;
- Inability to understand the research content and requirements;
Who the study is looking for
- Non-brain metastasis cohort: patients with stage IV non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) confirmed by pathology and imaging, without brain metastasis; Brain metastasis cohort: patients with pathologically and radiologically confirmed stage IV NSCLC and SCLC accompanied by brain metastasis;
- Eastern Cooperative Oncology Group (ECOG) performance status score ≤ 2;
- Age ≥ 18 years old;
- Estimated survival time ≥ 3 months;
- Capable and willing to repeatedly complete electronic questionnaires via smartphones or tablets;
- All enrolled patients signed the hospital-approved informed consent form.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Coordinator of this site? Confirm its status | Hubei | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.