NCT07912242Not yet recruiting
Cerebellar Brain Stimulation Plus Language Therapy for People at Risk of Poor Aphasia Recovery After Stroke
Predicting Aphasia Recovery and Testing Cerebellar Neuromodulation (PART-CN): A Pilot Wait-List Randomized Trial of Cathodal Cerebellar Transcranial Direct Current Stimulation Plus Computerized Language Therapy in Stroke Survivors Predicted to Have Poor Language Recovery
Source: ClinicalTrials.gov · Last updated 3 Nov 2026
Brief summary (registry, in English)
This pilot study tests whether a mild form of brain stimulation to the cerebellum, combined with computer-based language therapy, helps people recover language after a stroke when a poor natural recovery is predicted. People already taking part in a Johns Hopkins study of stroke and language recovery, whose early data suggest the aphasia is unlikely to resolve without treatment, are invited about 3 months after the stroke. Half begin 15 treatment sessions right away and half begin about 3 months later. Each session pairs 25 minutes of transcranial direct current stimulation (tDCS) over the right cerebellum with 45 to 60 minutes of language exercises, with a speech-language pathologist present. The main question is whether language ability, measured with the Western Aphasia Battery-Revised Aphasia Quotient, improves more by 6 months after stroke in the group treated first than in the group still waiting. The study also checks how accurately a machine learning model, built from data collected in the first days after stroke, predicted each person's language ability 12 months after stroke.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 8 (estimated)
- First submitted
- 27 Oct 2026
- Start date
- Nov 2026
- Primary completion date
- 1 Jun 2028
- Lead sponsor
- Johns Hopkins University
- Diseases
- Stroke
- NCT number
- NCT07912242
What you commit to
- Study type: Interventional
- Planned participants: 8
- From Nov 2026 to the primary completion date, 1 Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous neurological disorder other than stroke affecting the brain, or any neurodegenerative or psychiatric disorder
- Seizures during the previous 6 months
Other illness
- Use of medications that lower the seizure threshold (e.g., methylphenidate)
- History of brain surgery or any metal in the head
Other
- Lesion in the right cerebellum
- Uncorrected visual or hearing loss by self-report
- Use of N-methyl-D-aspartate (NMDA) receptor antagonists (e.g., memantine)
- Severely impaired auditory comprehension (below 2 on the Western Aphasia Battery-Revised Auditory Verbal Comprehension sub-score)
- Severely limited verbal output (below 2 on the Western Aphasia Battery-Revised Spontaneous Speech rating)
Who the study is looking for
- Enrolled in the Johns Hopkins longitudinal stroke and aphasia study (IRB NA\_00042097)
- Consented to future contact for research studies
- Predicted to have poor language recovery from acute-phase data, defined as a predicted Western Aphasia Battery-Revised Aphasia Quotient below 93.8 at 12 months post-stroke
- Ischemic left hemisphere stroke
- Aphasia with naming impairment on the Western Aphasia Battery-Revised
- Approaching 3 months post-stroke at enrollment
- Fluent speaker of English by self-report
- Age 18 or older
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Johns Hopkins Hospital, Phipps Building Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.