NCT07914075Recruiting
Kidney Stiffness Measured by Ultrasound in Patients With High Blood Pressure and Healthy Volunteers
Kidney Shear Wave elasTography for REnal Stiffness in SyStemic Hypertension: a Prospective Pilot Study (K-STRESS Study)
Source: ClinicalTrials.gov · Last updated 3 Nov 2026
Brief summary (registry, in English)
High blood pressure (hypertension) is a leading cause of kidney damage, but detecting early kidney changes remains challenging with currently available tools. This study investigates whether kidney stiffness, measured by a non-invasive ultrasound technique called shear wave elastography (SWE), differs across different subtypes of hypertension and healthy volunteers, and whether it may serve as an early marker of hypertension-related kidney damage. Adults with essential hypertension, renovascular hypertension, and primary aldosteronism, as well as healthy volunteers, undergo kidney ultrasound with SWE measurements combined with standard clinical, laboratory, and vascular assessments, with the aim of identifying the independent factors influencing kidney stiffness and evaluating its potential role as a simple, painless, and widely available imaging biomarker of kidney damage
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 240 (estimated)
- First submitted
- 20 Oct 2026
- Start date
- 11 Aug 2026
- Primary completion date
- 31 Jan 2029
- Lead sponsor
- Azienda Ospedaliera di Padova
- NCT number
- NCT07914075
What you commit to
- Study type: Observational
- Planned participants: 240
- From 11 Aug 2026 to the primary completion date, 31 Jan 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- renal transplant recipients
Other illness
- Known parenchymal renal disease other than hypertensive nephrosclerosis, including but not limited to glomerulonephritis, polycystic kidney disease, congenital nephropathy, and storage/infiltrative diseases (e.g. amyloidosis, Fabry disease), as classified according to KDIGO 2024 CKD guidelines (the presence of diabetes mellitus, cardiovascular disease, or peripheral artery disease does not constitute an exclusion criterion)
Other
- patients with urinary tract obstruction
- pregnant women
- BMI \>40
- Kidney lesions such as renal stones/mass/Hydroureteronephrosis(HUN) or renal cyst in site where SWE will be performed (side specific, not patient specific exclusion criterion)
Who the study is looking for
- Adults ≥18 y
- Informed consent signed
- diagnosis of essential or secondary hypertension or willingness to participate as healthy controls
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Azienda Ospedale Università di Padova Coordinator of this site? Confirm its status | Padova | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.