NCT07914387Not yet recruitingPhase 1
Stanford University Neurofiber Study
Source: ClinicalTrials.gov · Last updated 3 Nov 2026
Brief summary (registry, in English)
Parkinson's disease often causes constipation and changes in gut bacteria, but it is not known how quickly a daily fiber supplement changes gut physiology in people with Parkinson's, or how long any change lasts after stopping. This study will test how a daily fiber bar affects bowel function and gut inflammation in people with Parkinson's disease and in household members who live with them. Participants will eat one fiber bar (11 grams of fiber) each day for 3 months, then stop and be followed for one more month, for about 4 months in total. At three points (before starting, after 3 months of fiber, and one month after stopping), participants will collect a stool sample at home and mail it to Stanford in a provided kit, so no clinic visits are needed. Every week, participants will also fill out a short questionnaire about how often they have bowel movements, their bowel regimen, and they will complete a questionnaire about how bowel symptoms affect their daily life. In the lab, we will measure proteins in the stool that are signs of gut inflammation. We want to learn how fast these proteins change when fiber is added, whether changes last after fiber is stopped, and whether people with Parkinson's respond differently than their household partners. We expect that fiber will change gut inflammation and bowel function during the fiber period, and that these changes will differ between people with Parkinson's and their partners after the fiber bars are stopped. Results may help guide future research on diet and gut function in Parkinson's disease.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 26 Oct 2026
- Start date
- 1 Dec 2026
- Primary completion date
- 1 Jul 2027
- Lead sponsor
- Stanford University
- Diseases
- Parkinson disease
- NCT number
- NCT07914387
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 50
- From 1 Dec 2026 to the primary completion date, 1 Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Antibiotic use in the 2 weeks before baseline
- Use of probiotic supplements in the 2 weeks before baseline
- Antibiotic use in the 2 weeks before baseline
- Use of probiotic supplements in the 2 weeks before baseline
Other illness
- Allergy or intolerance to any ingredient in the study bar, including tree nuts, seeds, oats, coconut, or green tea extract
- History of bowel obstruction or major gastrointestinal surgery that makes a daily fiber supplement unsafe
- Celiac disease, or severe kidney or liver disease, by participant report
- History of inflammatory bowel disease (IBD)
- Undergoing active treatment for cancer with chemotherapy or immunotherapy
- Diagnosis of or current concern for dementia
- Allergy or intolerance to any ingredient in the study bar, including tree nuts, seeds, oats, coconut, or green tea extract
- History of bowel obstruction or major gastrointestinal surgery that makes a daily fiber supplement unsafe
- Celiac disease, or severe kidney or liver disease, by participant report
- History of inflammatory bowel disease (IBD)
- Undergoing active treatment for cancer with chemotherapy or immunotherapy
- History of neurodegenerative disease, including Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), Frontotemporal dementia, Multiple Sclerosis
Other
- Difficulty swallowing (dysphagia) that makes eating a dense, solid food bar unsafe
- Pregnant or lactating (breastfeeding), by participant report
- Consuming a fiber supplement
- Difficulty swallowing (dysphagia) that makes eating a dense, solid food bar unsafe
- Pregnant or lactating (breastfeeding), by participant report
- Consuming a fiber supplement
Who the study is looking for
- Diagnosed with Parkinson's disease by a movement disorders specialist
- Age 18+
- Lives with a participant in this study enrolled or planning to enroll in Arm 2
- Not currently consuming a fiber supplement
- No history of neurodegenerative disease, including Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), Frontotemporal dementia, Multiple Sclerosis
- Age 18+
- Lives with a participant in this study enrolled or planning to enroll in Arm 1
- Not currently consuming a fiber supplement
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Stanford University Neurosciences Coordinator of this site? Confirm its status | Stanford | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.