NCT07914829Not yet recruiting
Personalized Dietary Feedback to Reduce Hepatic Steatosis in Patients With MASLD
Effect of Personalized Dietary and Lifestyle Feedback on Hepatic Steatosis in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Prospective, Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 4 Nov 2026
Brief summary (registry, in English)
Metabolic dysfunction-associated steatotic liver disease (MASLD) and combined metabolic dysfunction and alcohol-associated liver disease (MetALD) are common chronic liver diseases associated with metabolic dysfunction and an increased risk of liver-related and cardiovascular complications. Lifestyle modification, particularly dietary changes and increased physical activity, represents a cornerstone of treatment. However, general lifestyle recommendations are often insufficient to achieve sustained improvements. This prospective, randomized controlled trial aims to investigate whether personalized dietary and lifestyle feedback based on a structured questionnaire is more effective in reducing hepatic steatosis than generic lifestyle recommendations. A total of 174 patients with MASLD or MetALD will be randomized 1:1 to receive either personalized or generic written feedback at baseline and after 2, 4, and 6 months. Changes in hepatic steatosis, assessed by the controlled attenuation parameter (CAP), will be evaluated over a six-month period.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 174 (estimated)
- First submitted
- 20 Oct 2026
- Start date
- 1 Nov 2026
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- Medical University of Vienna
- Diseases
- Fatty liver disease (MASLD/MASH)
- NCT number
- NCT07914829
What you commit to
- Study type: Interventional
- Planned participants: 174
- From 1 Nov 2026 to the primary completion date, 31 Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
AI-kivonat: who the study is looking for
Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with fatty liver disease (MASLD or MetALD) and a raised liver fat reading. It tests personal diet and lifestyle feedback against general advice.
- Age
- 18 to 80 years
- Sex
- Women and men can join.
- Disease stage
- Fatty liver with a controlled attenuation parameter (CAP) above 248 dB/m.
- Earlier treatment
- People who started or changed the dose of GLP-1 receptor agonists or other weight-changing medicines in the past three months cannot join.
- Biomarker or test result
- CAP above 248 dB/m.
Main reasons for not taking part
- Other active chronic liver disease
- Heavy alcohol use: 50 g/day or more for women, 60 g/day or more for men
- Pregnancy or breastfeeding
- Type 1 diabetes
- Planned weight-loss (bariatric) surgery during the trial
Read by machine on 9 Nov 2026.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Initiation or dose modification of GLP-1 receptor agonists or other weight-modifying pharmacological therapies within the previous three months.
- Planned bariatric surgery during study participation.
Other illness
- Other active chronic liver disease.
- Type 1 diabetes mellitus.
- Severe or unstable medical condition that, in the investigator's judgment, may interfere with study participation or interpretation of study results.
Other
- Significant alcohol consumption, defined as ≥50 g/day in women or ≥60 g/day in men.
- Pregnancy or breastfeeding.
Who the study is looking for
- Age 18-80 years.
- Controlled attenuation parameter (CAP) >248 dB/m.
- Sufficient German language proficiency to independently complete the questionnaires.
- Written informed consent to participate in the study.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of Vienna | Vienna | Austria | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.