Multi-center Prospective Validation of Real-Time AI-EGGIM System

Brief summary (registry, in English)

Gastric intestinal metaplasia (GIM) is a precancerous condition associated with an increased risk of gastric cancer. The endoscopic grading of gastric intestinal metaplasia (EGGIM) score evaluates the extent of GIM across five standard gastric regions. The investigators developed a real-time artificial intelligence-assisted EGGIM (AI-EGGIM) system that automatically assigns an intestinal metaplasia grade to each region and calculates a total EGGIM score. This prospective multi-center validation study will consecutively enroll patients undergoing upper gastrointestinal endoscopy. The AI-EGGIM system will generate real-time grades for the five standard gastric regions. Regardless of endoscopic appearance or AI output, every patient will undergo five mapping biopsies, with one biopsy obtained from each standard region. Histopathological operative link on gastric intestinal metaplasia (OLGIM) staging will serve as the reference standard. The primary objective is to estimate the performance of an AI-EGGIM score ≥ 5 for identifying patients at high risk of gastric cancer.

What you commit to

• Study type: Observational
• Planned participants: 540
• From 1 Nov 2026 to the primary completion date, 31 Mar 2027
• 3 sites in 1 country
• Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study design.

AI-kivonat: who the study is looking for

Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults having an upper gastrointestinal endoscopy who are aged 40-75 years, or who have had H. pylori infection or known stomach lesions that can lead to cancer.

Age

40-75 years, or any age with a history of H. pylori infection and/or known premalignant gastric lesions (e.g., atrophic gastritis and IM)

Sex

All sexes can join.

Disease stage

People having an upper gastrointestinal endoscopy. A history of H. pylori infection and/or known premalignant gastric lesions (e.g., atrophic gastritis and IM) is one way to join.

Earlier treatment

People who have had previous stomach surgery cannot join.

Main reasons for not taking part

• Severe heart, brain, lung or kidney problems, or psychiatric disorders, that make upper endoscopy impossible
• Previous surgery on the stomach
• Upper gastrointestinal cancer
• A medical reason that rules out a stomach lining biopsy

Read by machine on 9 Nov 2026.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Who the study is looking for

Sex: All

Full criteria on ClinicalTrials.gov

Sites (3)

Sites in registry order. Save your city in your profile to sort them by distance.

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