NCT07918417Not yet recruiting
Exercise in Alzheimer's Disease: Functional Biomarkers
Physical Exercise in Alzheimer's Disease: Impact on Functional Biomarkers and the Muscle-Gut-Brain Axis
Source: ClinicalTrials.gov · Last updated 5 Nov 2026
Brief summary (registry, in English)
Alzheimer's disease (AD) is the leading cause of dementia worldwide and involves systemic alterations beyond the brain, such as loss of muscle strength, chronic low-grade inflammation, and gut microbiome dysbiosis. Physical exercise is a promising non-pharmacological therapy, and velocity-based resistance training has proven safe and effective in older adults. However, the effects of performing resistance exercises at high versus moderate velocity in people with AD remain unknown, and human evidence on how exercise modulates the gut microbiome in AD is very limited. This study aims to assess and compare the effects of two velocity-based resistance training modalities (high load at moderate velocity and moderate load at high velocity) versus usual care on the gut microbiome, systemic inflammation, plasma biomarkers, biological age, and intrinsic capacity in older adults with mild-to-moderate AD, using cognitively healthy older adults as a reference group.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 48 (estimated)
- First submitted
- 26 Oct 2026
- Start date
- 10 Nov 2026
- Primary completion date
- 31 Oct 2027
- Lead sponsor
- European University Miguel de Cervantes
- Diseases
- Alzheimer disease
- NCT number
- NCT07918417
What you commit to
- Study type: Interventional
- Planned participants: 48
- From 10 Nov 2026 to the primary completion date, 31 Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Major surgery in the previous 3 months
- Antibiotic, probiotic or corticosteroid treatment in the 4 weeks before biological sample collection
Other illness
- Uncontrolled neuromuscular disease or severe heart disease
Other
- Total functional dependence
Who the study is looking for
- Age ≥ 60 years
- Medical diagnosis of mild or moderate Alzheimer's disease based on clinical criteria and plasma biomarkers.
- Able to perform physical activity according to medical assessment
- Written informed consent from the participant or, when capacity is insufficient, from the legal representative
- Age ≥ 60 years
- No medical diagnosis of Alzheimer's disease or cognitive impairment according to clinical criteria
- Preserved functional autonomy
- Able to perform physical activity according to medical assessment
- Written informed consent
Age in the registry: 60 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Miguel de Cervantes European University | Valladolid | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.