NCT07918690Recruiting
dPmax for Predicting Right Ventricular Failure After Left Ventricular Assist Device Implantation
Predictive Value of dPmax Measured by Pulse Contour Analysis for Postoperative Right Ventricular Failure in Patients Undergoing LVAD Implantation
Source: ClinicalTrials.gov · Last updated 5 Nov 2026
Brief summary (registry, in English)
This single-center, prospective observational study aims to evaluate whether dPmax, a measure of the maximum rate of arterial pressure rise obtained through pulse contour analysis, can predict right ventricular failure after left ventricular assist device (LVAD) implantation in adults. Measurements collected during routine monitoring before and after anesthesia induction will be analyzed alongside preoperative echocardiographic findings. The primary outcome is right ventricular failure within 30 days after surgery, assessed using Mechanical Circulatory Support-Academic Research Consortium (MCS-ARC) criteria. Secondary objectives include comparing the predictive performance of dPmax with the ratio of tricuspid annular plane systolic excursion to pulmonary artery systolic pressure (TAPSE/SPAP) and identifying an optimal dPmax threshold for predicting right ventricular failure. No additional invasive procedures will be performed for research purposes.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 89 (estimated)
- First submitted
- 1 Nov 2026
- Start date
- 3 Jun 2026
- Primary completion date
- Sept 2029
- Lead sponsor
- Pınar Kırdemir
- Diseases
- Heart failure
- NCT number
- NCT07918690
What you commit to
- Study type: Observational
- Planned participants: 89
- From 3 Jun 2026 to the primary completion date, Sept 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Congenital heart disease associated with transposition of the great arteries.
- Severe aortic regurgitation, severe peripheral arterial disease, or refractory and uncontrolled tachyarrhythmia that may interfere with arterial waveform analysis.
- Unwillingness to participate or cognitive impairment preventing informed consent.
Other
- Ongoing extracorporeal membrane oxygenation (ECMO) or extracorporeal ventricular assist device (ExVAD) support immediately before LVAD implantation.
Who the study is looking for
- Age 18 years or older.
- Scheduled for left ventricular assist device (LVAD) implantation.
- Availability of the clinical data required for the study.
- Willingness and ability to provide informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ankara Bilkent City Hospital Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.