NCT07918794Completed
Comparison of Sequential vs. Simultaneous Adrenal Vein Sampling
Procedural and Diagnostic Concordance of Sequential Versus Simultaneous Adrenal Vein Sampling Without ACTH Stimulation
Source: ClinicalTrials.gov · Last updated 5 Nov 2026
Brief summary (registry, in English)
This study is a retrospective review that compared two different techniques for a diagnostic procedure called adrenal vein sampling (AVS) in patients with a hormone condition known as primary aldosteronism. AVS is used to determine if one or both adrenal glands are overproducing a hormone called aldosterone, which causes high blood pressure. The two techniques compared were "simultaneous" AVS (taking blood samples from both adrenal veins at the same time) and "sequential" AVS (taking blood samples from one adrenal vein and then the other). The goal was to evaluate both techniques for identifying the source of the hormone problem and to compare their safety and efficiency. The study retrospectively reviewed the medical records of 238 patients who underwent AVS without using a stimulating drug (ACTH). The study assessed catheter placement success, diagnostic concordance between the two methods, fluoroscopy time, radiation dose, and procedure-related complications.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 238 (actual)
- First submitted
- 21 Nov 2025
- Start date
- 1 Sept 2022
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- Yahao Zhang
- Diseases
- High blood pressure
- NCT number
- NCT07918794
What you commit to
- Study type: Observational
- Participants enrolled: 238
- From 1 Sept 2022 to the primary completion date, 31 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Lab values
- Patients who underwent AVS with pharmacologic stimulation (e.g., cosyntropin).
- Confirmed or suspected ectopic ACTH secretion, primary adrenal insufficiency, or other forms of mineralocorticoid excess.
- Severe renal impairment (e.g., estimated glomerular filtration rate \< 30 mL/min/1.73 m²).
- Active malignancy (excluding non-melanoma skin cancer) within 5 years.
- Child-Pugh class C hepatic impairment.
- Individuals with incomplete procedural, laboratory, or follow-up data essential for endpoint analysis.
Who the study is looking for
- Hospitalized patients with confirmed Primary Aldosteronism (PA).
- Underwent adrenal vein sampling (AVS) between September 2022 and December 2024 at one of the participating centers.
- AVS was performed without adrenocorticotropic hormone (ACTH) stimulation.
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital of University of Science and Technology of China Coordinator of this site? Confirm its status | Hefei | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.