NCT07918885Not yet recruiting
High-Flow Nasal Oxygen-Assisted Deep Extubation Versus Awake Extubation in Morbidly Obese Patients
HFNO-Assisted 'No-Touch' Deep Extubation Versus Conventional Awake Extubation in Morbidly Obese Patients Undergoing Elective Laparoscopic Surgery: A Prospective Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 5 Nov 2026
Brief summary (registry, in English)
This prospective, randomized controlled trial aims to compare two methods of tracheal extubation after general anesthesia in adults with morbid obesity undergoing elective laparoscopic surgery. A total of 120 patients will be randomly assigned to one of two groups. In the first group, the breathing tube will be removed while the patient remains deeply anesthetized, followed immediately by heated and humidified high-flow nasal oxygen (HFNO). Patients will then be allowed to awaken without unnecessary stimulation. In the second group, the breathing tube will be removed after the patient is fully awake, followed by conventional oxygen therapy through a face mask. The primary objective is to determine whether HFNO-assisted deep extubation reduces the incidence of coughing during the first 15 minutes after extubation compared with conventional awake extubation. The study will also assess respiratory complications, the need for airway interventions, hemodynamic changes, recovery times, and adverse events associated with the two extubation approaches. The findings may help inform airway management strategies during recovery from general anesthesia in patients with morbid obesity.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 26 Oct 2026
- Start date
- Nov 2026
- Primary completion date
- Apr 2027
- Lead sponsor
- Fayoum University
- Diseases
- Obesity
- NCT number
- NCT07918885
What you commit to
- Study type: Interventional
- Planned participants: 120
- From Nov 2026 to the primary completion date, Apr 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with known or anticipated difficult airway (Mallampati III-IV, previous history of difficult intubation, limited mouth opening, or cervical spine immobility).
- Patients with severe obstructive sleep apnea (OSA) on home CPAP/BiPAP therapy who cannot tolerate nasal cannula delivery systems.
- Emergency surgical procedures.
Other illness
- Active gastroesophageal reflux disease (GERD) with aspiration risk.
- Patients with significant cardiovascular disease (NYHA class III-IV heart failure, unstable angina, or recent myocardial infarction within 6 months).
- Patients with severe pulmonary disease (FEV₁ \< 50% predicted, chronic hypercapnia, or oxygen-dependent respiratory failure).
- Patients with nasal obstruction, facial deformity, or conditions precluding HFNO delivery.
Other
- Pregnant patients.
Who the study is looking for
- Adult patients aged 18-60 years. • BMI ≥ 40 kg/m² (morbidly obese). • American Society of Anesthesiologists (ASA) physical status classification II-III.
- Patients scheduled for elective laparoscopic surgery .
- Mallampati score I or II (anticipated non-difficult airway).
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.