NCT07922200Recruiting
Biomarkers of Paired VNS
Biomarkers of Paired Vagus Nerve Stimulation Therapy for Stroke Motor Rehabilitation
Source: ClinicalTrials.gov · Last updated 6 Nov 2026
Brief summary (registry, in English)
Paired Vagus Nerve Stimulation (VNS) has been shown to enhance upper extremity motor recovery after ischemic stroke. Prior studies have focused primarily on long-term clinical outcomes, leaving the short-term physiologic response to the intervention poorly understood. The purpose of this study is to examine real-time responses to Vagus Nerve Stimulation (VNS) in individuals with chronic motor impairments after ischemic stroke to better inform Paired VNS dosing. We plan to enroll 50 participants into a single-arm study and perform neurophysiologic assessments during VNS to identify objective markers of stimulation response and examine dose-response relationships.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 2 Nov 2026
- Start date
- 26 Mar 2026
- Primary completion date
- 1 Oct 2029
- Lead sponsor
- MGH Institute of Health Professions
- Diseases
- Stroke
- NCT number
- NCT07922200
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 26 Mar 2026 to the primary completion date, 1 Oct 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
AI-kivonat: who the study is looking for
Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 80 who have a vagus nerve stimulation (VNS) device implanted to help recovery after an ischemic stroke. It studies how the body responds to the stimulation in real time.
- Age
- 18 to 80 years old
- Sex
- All sexes can join.
- Disease stage
- Chronic motor impairments after an ischemic stroke.
- Earlier treatment
- Must already have a VNS device implanted for post-stroke motor rehabilitation.
Main reasons for not taking part
- Past developmental, neurologic or major psychiatric disorder that caused functional disability
- Visual or hearing problems that limit taking part in study procedures
- Uncontrolled seizure disorder
- EEG leads cannot be used
- Pregnancy
Read by machine on 9 Nov 2026.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior history of developmental, neurologic, or major psychiatric disorder resulting in functional disability
Other illness
- Visual or auditory disorders limiting ability to participate in study procedures
- Evidence of an uncontrolled seizure disorder
Other
- Patients for whom EEG leads are contraindicated
- Pregnancy
Who the study is looking for
- Age ≥ 18 years old and ≤ 80 years old
- Implanted with VNS device for post-stroke motor rehabilitation
- Ability to follow simple commands in English
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| MGH Institute of Health Professions | Boston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.