NCT07923513Not yet recruiting
Compulsive Eating and Brain's Reward System in Different Pathologies
Bipolar Disorders, Parkinson's Disease, ObesiTy and Compulsive eAting: TransnosOlogical Assessement of the Brain's Reward System
Source: ClinicalTrials.gov · Last updated 6 Nov 2026
Brief summary (registry, in English)
Compulsive eating behaviors represent a significant issue across various disorders such as Parkinson's disease, bipolar disorders, and obesity. Despite their apparent differences, these conditions share common underlying disturbances involving the brain's reward system, particularly within dopaminergic networks.6,7 Previous neuroimaging studies have consistently reported reward system connectivity impairment associated with compulsive eating, in each of these disorders. However, few studies have simultaneously explored the neurobiological similarities and specificities of this common symptom, eating behavior, when occurring in different populations and disorders. The Bi-POTATOS project proposes an original and innovative approach by adopting a transdiagnostic perspective, employing brain imaging and comprehensive psycho-behavioral assessments to investigate common behavioral characteristics and neural circuit alterations associated with compulsive eating across these three conditions. For the first time, this study will allow a direct comparison of the cerebral signatures linked to compulsive eating behavior, clearly distinguishing between transdiagnostic vulnerabilities and features unique to each clinical condition. The central hypothesis is that similar dysfunctions in brain regions involved in motivation and impulsive decision-making underpin compulsive eating behaviors, irrespective of the initial diagnosis. However, the underlying pathology may modulate these mechanisms, introducing certain specificities. By clarifying these common mechanisms, the Bi-POTATOS project will not only enhance our understanding of the neurobiological etiology of these disorders but also pave the way for innovative, targeted therapeutic interventions. This project will precisely identify whether specific neural alterations constitute a universally relevant therapeutic target, or conversely, determine which alterations necessitate tailored therapeutic strategies based on the underlying pathology.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- First submitted
- 27 Jul 2026
- Start date
- Dec 2026
- Primary completion date
- Jul 2029
- Lead sponsor
- University Hospital, Clermont-Ferrand
- Diseases
- Obesity, Bipolar disorder, Parkinson disease
- NCT number
- NCT07923513
What you commit to
- Study type: Interventional
- Planned participants: 150
- From Dec 2026 to the primary completion date, Jul 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treated with deep brain stimulation
- Treated with deep brain stimulation or vagus nerve stimulation
Other illness
- Dementia (MoCA <22)
- History of stroke or brain trauma that may impact MRI findings
- Patient suffering from psychiatric disorder
- Suffering from progressive neurological pathology and psychiatric disorder
- History of bariatric surgery
- Suffering from neurological pathology and psychiatric disorder other than bipolar disorder
Other
- 1-Common Criteria
- Severe depression (Beck Depression Inventory>30)
- Contraindications to MRI (implanted stimulator, insulin pump, intraocular metallic foreign bodies or close to the nervous and vascular systems, claustrophobia, non-removable dental appliance, tattoo on the face or neck, …)
- Refusal to be informed in case of incidental finding on MRI
- Patients under guardianship, deprived of freedoms or protection of justice.
- Pregnant women, breastfeeding women
- 2- Specific criteria
- Parkinsonian patients:
- People suffering from neurological pathologies other than PD
- Patients with severe tremor (> 3 for a tremor sub-item of the MDS-UPDRS III) or excessively severe dyskinesia contraindicating MRI
- Obese patients:
- Weight >220kg contraindicating MRI
- Body (Shoulder) diameter > 220 cm contraindicating MRI
- GLP1 treatment
- Bipolar patients:
- Current acute depressive or hypomanic episode according to DSM 5
- Electroconvulsivotherapy < 6 months
Who the study is looking for
- 1-Common Criteria (Parkinson disease, Obesity, Bipolar patients)
- Men or women, right-handed, 18 to 80 years old
- With or without compulsive eating according to the QEWP-R
- No changes to long-term treatments in the previous month
- Cooperation and understanding to strictly comply with the conditions set out in the protocol
- Acceptance of the protocol and signing of a written informed consent
- Affiliation to the social security system
- 2-Specific criteria Parkinsonian patients (n=25 with CE, n=25 without CE)
- Diagnosis of Parkinson's disease according to the Movement Disorders Society criteria
- BMI<30
- Obese patients (n=25 with CE, n=25 without CE)
- Obese patients according to HAS 2022 classification
- BMI≥30
- Bipolar patients (n=25 with CE, n=25 without CE)
- Diagnosis of bipolar disorder according to DSM 5 criteria
- BMI<30
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de Clermont-Ferrand Coordinator of this site? Confirm its status | Clermont-Ferrand | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.