Ocular Changes in Patients Using Tirzepatide or Semaglutide

Brief summary (registry, in English)

This prospective observational study aims to evaluate ocular structural and microvascular changes in adults with obesity who are receiving semaglutide or tirzepatide as part of routine clinical care. Participants with and without type 2 diabetes mellitus will be included. Participants will undergo ophthalmologic examinations at baseline and during follow-up. Changes in optic nerve head parameters, retinal thickness, retinal and choroidal microvascular parameters, and choroidal thickness will be assessed using optical coherence tomography (OCT), optical coherence tomography angiography (OCT-A), and other routine ophthalmologic examination methods. The study will compare ocular measurements obtained at baseline and during follow-up to investigate changes associated with semaglutide or tirzepatide treatment over a period of up to 18 months.

What you commit to

• Study type: Observational
• Planned participants: 40
• From 1 Mar 2026 to the primary completion date, 17 Sept 2027
• 1 site in 1 country
• Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study design.

AI-kivonat: who the study is looking for

Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with obesity who already take semaglutide or tirzepatide as part of routine care. People with or without type 2 diabetes can join.

Age

18 years or older

Sex

All sexes can join.

Disease stage

Obesity, with or without type 2 diabetes.

Earlier treatment

Must be receiving semaglutide or tirzepatide as part of routine clinical care.

Main reasons for not taking part

• Under 18 years of age
• Not receiving semaglutide or tirzepatide
• Cannot complete the required eye examinations or imaging

Read by machine on 10 Nov 2026.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Who the study is looking for

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

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