Childhood cancers: open trials in Canada

154 open trials have a site in Canada. Registry data; only the trial team decides who can take part.

NCT05384626
A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)
Trial Treatment · Phase 1/2 · Nuvalent Inc.
Cross Cancer Institute, Edmonton · The Ottawa Hospital Cancer Center, Ottawa · Princess Margaret Cancer Centre, Toronto · BC Cancer Center, Vancouver
Registry updated 2026-11-06
NCT05862285
A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study
Trial Treatment · Phase 3 · Hoffmann-La Roche
Princess Margaret Cancer Center, Toronto
Registry updated 2026-11-06
NCT05675410
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab
Trial Treatment · Phase 3 · National Cancer Institute (NCI)
Alberta Children's Hospital, Calgary · University of Alberta Hospital, Edmonton · IWK Health Centre, Halifax · McMaster Children's Hospital at Hamilton Health Sciences, Hamilton · Children's Hospital, London · Centre Hospitalier Universitaire Sainte-Justine, Montreal · The Montreal Children's Hospital of the MUHC, Montreal · Children'S Hospital Of Eastern Ontario, Ottawa · CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec · Jim Pattison Children's Hospital, Saskatoon · Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke · Hospital for Sick Children, Toronto · British Columbia Children's Hospital, Vancouver · CancerCare Manitoba, Winnipeg
Registry updated 2026-11-05
NCT05734066
Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma
Trial Treatment · Phase 1/2 · Jazz Pharmaceuticals
The Hospital for Sick Children, Toronto
Registry updated 2026-11-05
NCT04811560
A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)
Trial Treatment · Phase 1/2 · Janssen Research & Development, LLC
Hôpital Maisonneuve-Rosemont, Montreal · Princess Margaret Cancer Centre - University Health Network, Toronto · Vancouver Coastal Health, Vancouver
Registry updated 2026-11-04
NCT07765069
Positioning in RT - Supine vs. Upright
Research · University Health Network, Toronto
Princess Margaret Cancer Centre, Toronto
Registry updated 2026-11-04
NCT03340506
Dabrafenib and/or Trametinib Rollover Study
Trial Treatment · Phase 4 · Novartis Pharmaceuticals
Toronto
Registry updated 2026-11-03
NCT04924075
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
Trial Treatment · Phase 2 · Merck Sharp & Dohme LLC
Arthur J.E. Child Comprehensive Cancer Centre (Site 0203), Calgary · Princess Margaret Cancer Centre (Site 0202), Toronto
Registry updated 2026-11-03
NCT03435796
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
Trial Treatment · Phase 2/3 · Celgene
University Of Calgary, Calgary · Hamilton · CIUSSS de l'Est-de-l'Île-de-Montréal, Montreal · Princess Margaret Cancer Centre, Toronto · Vancouver
Registry updated 2026-11-02
NCT06942039
Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation
Trial Treatment · Early phase 1 · C17 Council
Alberta Children's Hospital, Calgary · Stollery Children'S Hospital, Edmonton · IWK Health Centre, Halifax · McMaster Children's Hospital, Hamilton · London Health Sciences Centre, London · CHU Sainte-Justine, Montreal · Montreal Children's Hospital (McGill), Montreal · Children'S Hospital Of Eastern Ontario, Ottawa · CHU de Quebec-Universite Laval, Québec · Centre hospitalier universitaire de Sherbrooke (CHUS), Sherbrooke · The Hospital for Sick Children, Toronto · BC Children ' s Hospital, Vancouver · CancerCare Manitoba (CCMB), Winnipeg
Registry updated 2026-11-02
NCT06172296
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
Trial Treatment · Phase 3 · National Cancer Institute (NCI)
Alberta Children's Hospital, Calgary · University of Alberta Hospital, Edmonton · IWK Health Centre, Halifax · McMaster Children's Hospital at Hamilton Health Sciences, Hamilton · Children's Hospital, London · The Montreal Children's Hospital of the MUHC, Montreal · Centre Hospitalier Universitaire Sainte-Justine, Montreal · Children'S Hospital Of Eastern Ontario, Ottawa · CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec · Jim Pattison Children's Hospital, Saskatoon · Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke · Janeway Child Health Centre, St. John's · Hospital for Sick Children, Toronto · British Columbia Children's Hospital, Vancouver · CancerCare Manitoba, Winnipeg
Registry updated 2026-10-30
NCT06395103
Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
Trial Treatment · Phase 1/2 · Merck Sharp & Dohme LLC
Alberta Children's Hospital (Site 1227), Calgary · McGill University Health Centre-Pediatric HematologyOncology (Site 1223), Montreal · The Hospital for Sick Children (Site 1225), Toronto
Registry updated 2026-10-30
NCT07570173
A Clinical Trial of MK-1045 in People With B-cell Acute Lymphoblastic Leukemia (MK-1045-005)
Trial Treatment · Phase 2/3 · Merck Sharp & Dohme LLC
Princess Margaret Cancer Center (Site 0102), Toronto
Registry updated 2026-10-30
NCT05376891
Met Non Small Cell Cancer Registry (MOMENT)
Research · EMD Serono Research & Development Institute, Inc.
Ottawa Hospital - General Campus, Ottawa · Centre Intégré de Cancérologie du CHU de Québec, Québec · Princess Margaret Cancer Centre, Toronto · British Columbia Cancer Agency (6864), Vancouver
Registry updated 2026-10-29
NCT07516210
Adaptive Radiotherapy for Safe Hypofractionation
Trial Treatment · Phase 2 · Centre hospitalier de l'Université de Montréal (CHUM)
Centre Hospitalier de l'Université de Montréal, Montreal
Registry updated 2026-10-29
NCT04855656
Study of Lunresertib Alone or in Combination With RP-3500 or Zedoresertib (Debio 0123) in Patients With Advanced Solid Tumors
Trial Treatment · Phase 1 · Debiopharm International SA
#2003, The Research Institute of the McGill University Health Centre, Montreal · #2001, Princess Margaret Cancer Centre, Toronto · #2002, The Hospital for Sick Children, Toronto
Registry updated 2026-10-28
NCT00900198
Collection of Tissue Samples for Cancer Research
Research · National Cancer Institute (NCI)
Princess Margaret Hospital Cancer Centre, Toronto
Registry updated 2026-10-27
NCT06124157
A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)
Trial Treatment · Phase 2 · National Cancer Institute (NCI)
Alberta Children's Hospital, Calgary · University of Alberta Hospital, Edmonton · IWK Health Centre, Halifax · McMaster Children's Hospital at Hamilton Health Sciences, Hamilton · The Montreal Children's Hospital of the MUHC, Montreal · Centre Hospitalier Universitaire Sainte-Justine, Montreal · CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec · Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke · Hospital for Sick Children, Toronto · British Columbia Children's Hospital, Vancouver · CancerCare Manitoba, Winnipeg
Registry updated 2026-10-27
NCT06838676
ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas
Trial Treatment · Phase 2 · Nationwide Children's Hospital
Montreal Children's Hospital, Montreal · The Hospital for Sick Children (SickKids), Toronto
Registry updated 2026-10-23
NCT07155226
Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression
Trial Treatment · Phase 1/2 · AstraZeneca
Montreal · Toronto
Registry updated 2026-10-23
NCT07211958
Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation
Trial Treatment · Phase 3 · Syndax Pharmaceuticals
London · Montreal · Toronto
Registry updated 2026-10-21
NCT03394365
A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy
Trial Treatment · Phase 3 · Pierre Fabre Medicament
Alberta Children's Hospital (Adults and Pediatrics), Calgary · Princess Margaret Cancer Centre (Adults only), Toronto · Sick Kids (Pediatrics only), Toronto
Registry updated 2026-10-19
NCT07297667
GCAR1, a Chimeric Antigen Receptor (CAR) T-CELL Therapy for Relapsed/Refractory GPNMB-Expressing Solid Tumours
Trial Treatment · Phase 1 · Canadian Cancer Trials Group
Arthur J.E. Child Comprehensive Cancer Centre, Calgary · The Research Institute of the McGill University, Montreal · Ottawa Hospital Research Institute, Ottawa · University Health Network, Toronto
Registry updated 2026-10-16
NCT07109219
Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Acute Lymphoblastic Leukemia
Trial Treatment · Phase 1/2 · AstraZeneca
Toronto · Vancouver
Registry updated 2026-10-15
NCT07354074
Study to Determine the Efficacy and Safety of Asciminib in Pediatric Patients With Ph+ CML-CP
Trial Treatment · Phase 2 · Novartis Pharmaceuticals
Edmonton · Montreal
Registry updated 2026-10-15

All Childhood cancers trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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