Chronic lymphocytic leukaemia: open trials in Brazil

13 open trials have a site in Brazil. Registry data; only the trial team decides who can take part.

NCT05947851
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Hospital Amaral Carvalho-Centro de Pesquisas (Site 1304), Jaú · Hospital Paulistano-Americas Oncologia (Site 1302), São Paulo · ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO-Pesquisa Clinica (Site 1308), São Paulo
Registry updated 2026-11-06
NCT04728893
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
Trial Treatment · Phase 2 · Merck Sharp & Dohme LLC
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA (Site 0300), Rio de Janeiro · Hospital Paulistano - Amil Clinical Research (Site 0311), São Paulo · BP - A Beneficencia Portuguesa de São Paulo (Site 0302), São Paulo · Hospital das Clinicas FMUSP-Pesquisa Clínica Hematologia (Site 0303), São Paulo
Registry updated 2026-10-27
NCT06697184
A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.
Trial Treatment · Phase 1/2 · BeOne Medicines
Hcfmusp Pesquisa Clinica Do Servico de Hematologia E Terapia Celular, São Paulo · Hospital Santa Rita de Cassia Afecc, Vitória
Registry updated 2026-10-26
NCT06943872
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
Trial Treatment · Phase 3 · BeOne Medicines
CETUS, Belo Horizonte · Universidade de Campinas Centro de Hematologia E Hemoterapia, Campinas · Hospital Erasto Gaertner, Curitiba · Complexo Hospitalar de Niteroi, Niterói · Irmandade da Santa Casa de Misericórdia Hospital - Porto Alegre, Porto Alegre · Instituto Dor de Pesquisa E Ensino Rio de Janeiro, Rio de Janeiro · Hospital Sao Lucas, Rio de Janeiro · Hospital Santa Izabel, Salvador · Instituto Dor de Pesquisa E Ensino Sao Paulo, São Paulo · Instituto Brasileiro de Controle Do Câncer, São Paulo · Hospital Nove de Julho - dasa, São Paulo · Hcfmusp Pesquisa Clinica Do Servico de Hematologia E Terapia Celular, São Paulo · Hospital Samaritano Sao Paulo, São Paulo · Hospital Santa Rita de Cassia Afecc, Vitória
Registry updated 2026-10-23
NCT07024706
MAVRiC Studies 2L Treatment With AV in Patients With CLL/SLL Who Have Relapsed After a Course of BTKi + BCL2i Combination, With or Without Obinutuzumab
Trial Treatment · Phase 2 · AstraZeneca
Goiânia · Porto Alegre · São Paulo
Registry updated 2026-10-23
NCT06136559
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Hospital Erasto Gaertner (Site 2212), Curitiba · Hope - Humanizacao Em Oncologia, Pesquisa E Ensino (Site 2211), Ribeirão Preto · Instituto Nacional de Câncer - INCA (Site 2201), Rio de Janeiro · Hospital 9 De Julho (Site 2206), São Paulo · Hospital Paulistano-Americas Oncologia (Site 2202), São Paulo
Registry updated 2026-10-13
NCT05006716
A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
Trial Treatment · Phase 1/2 · BeOne Medicines
Hospital Sirio Libanes Brasilia, Brasília · Hospital Erasto Gaertner, Curitiba · Centro Gaucho Integrado de Oncologia Hospital Mae de Deus, Porto Alegre · Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo · Instituto Dor de Pesquisa E Ensino Sao Paulo, São Paulo · Hospital Nove de Julho - dasa, São Paulo · Real E Benemerita Associacao Portuguesa de Sao Paulo, São Paulo
Registry updated 2026-10-05
NCT06846671
A Study of Tacabrutideg (BGB-16673) Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors
Trial Treatment · Phase 3 · BeOne Medicines
CETUS, Belo Horizonte · Hospital Sirio Libanes Brasilia, Brasília · Hospital Erasto Gaertner, Curitiba · Centro de Ensino E Pesquisa Em Oncologia de Santa Catarina (Cepen), Florianópolis · Instituto Joinvilense de Hematologia e Oncologia, Joinville · Complexo Hospitalar de Niteroi, Niterói · Centro Gaucho Integrado de Oncologia Hospital Mae de Deus, Porto Alegre · Hospital Sao Lucas Dasa Oncologia, Rio de Janeiro · Oncoclinicas Rio de Janeiro Sa, Rio de Janeiro · Hospital Sao Rafael (Rede Dor), Salvador · Instituto Brasileiro de Controle Do Câncer, São Paulo · Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo · Instituto Dor de Pesquisa E Ensino Sao Paulo, São Paulo · Hospital Santa Rita de Cassia Afecc, Vitória
Registry updated 2026-09-28
NCT06973187
A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Trial Treatment · Phase 3 · BeOne Medicines
Centro de Pesquisa Clinica Dom Bosco Ltda, Araçatuba · Hospital Felicio Rocho, Belo Horizonte · ICTR - Instituto do Câncer e Transplante de Curitiba, Curitiba · Hospital de Clinicas de Goiania Ufg, Goiânia · INCA - Instituto Nacional de Câncer, Rio de Janeiro · Ensino e Terapia de Inovação Clínica AMO - ETICA, Salvador · Hcfmusp Hospital Das Clinicas Da Faculdade de Medicina Da Universidade de Sao Paulo, São Paulo · Hospital Nove de Julho - dasa, São Paulo
Registry updated 2026-09-28
NCT07277231
A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
Trial Treatment · Phase 3 · BeOne Medicines
Instituto Dor de Pesquisa E Ensino Distrito Federal, Brasília · Centro Gaucho Integrado de Oncologia Hospital Mae de Deus, Porto Alegre · Ensino e Terapia de Inovação Clínica AMO - ETICA, Salvador · Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo · Instituto Dor de Pesquisa E Ensino Sao Paulo, São Paulo
Registry updated 2026-09-28
NCT05254743
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Trial Treatment · Phase 3 · Loxo Oncology, Inc.
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos · Upeclin - Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu - UNESP, Botucatu · Hemocentro Unicamp, Campinas · Hospital Uopeccan - Centro de Pesquisa Clinica, Cascavel · Centro Integrado de Oncologia de Curitiba, Curitiba · Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer, Curitiba · Instituto do Câncer - Hospital São Vicente de Paulo, Passo Fundo · Centro Gaucho Integrado - Mae de Deus Center, Porto Alegre · Hospital de Clínicas de Ribeirão Preto, Ribeirão Preto · CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia, Santo André · Centro Integrado de Pesquisa Clinica, São José do Rio Preto · Hospital Santa Marcelina, São Paulo · Hospital da Clinicas da Faculdade de Medicina da USP, São Paulo · Hospital BP, São Paulo
Registry updated 2026-08-17
NCT04895436
Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)
Trial Treatment · Phase 2 · AbbVie
Hospital de Clinicas de Porto Alegre /ID# 243657, Porto Alegre · Hospital Nove de Julho /ID# 243658, São Paulo · Instituto de Ensino e Pesquisas Sao Lucas /ID# 243659, São Paulo
Registry updated 2026-02-09
NCT05705570
Clinical Trial Using CAR- T Cells for Treatment of Patients With Refractory or Relapsed CD19-positive B Lymphoid Malignancies
Trial Treatment · Phase 1 · Nelson Hamerschlak
Hospital Israelita Albert Einstein, São Paulo
Registry updated 2025-09-25

All Chronic lymphocytic leukaemia trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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