Colorectal cancer: open trials in Canada

89 open trials have a site in Canada. Registry data; only the trial team decides who can take part.

NCT04929223
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
Trial Treatment · Phase 1 · Hoffmann-La Roche
McGill University Health Center, Montreal · Jewish General Hospital, Montreal · Princess Margaret Cancer Center, Toronto
Registry updated 2026-11-06
NCT06983743
A Study of ERAS-0015 in Patients With Advanced or Metastatic Solid Tumors
Trial Treatment · Phase 1 · Erasca, Inc.
The Princess Margaret Cancer Center, Toronto
Registry updated 2026-11-06
NCT07913906
Alberta Cancer Exercise Dose in Colorectal Cancer
Trial Treatment · Phase 2 · University of Calgary
Arthur J.E. Child Comprehensive Cancer Centre - Gastrointestinal tumour group outpatient clinics, Calgary
Registry updated 2026-11-06
NCT07228832
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
Trial Treatment · Phase 3 · Summit Therapeutics
Brampton · Montreal · Regina · Toronto · Vancouver
Registry updated 2026-11-05
NCT07549412
A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
Trial Treatment · Phase 3 · EMD Serono Research & Development Institute, Inc.
The Ottawa Hospital Cancer Centre, Ottawa · University Health Network - Princess Margaret Cancer Centre, Toronto · BC Cancer - Vancouver - BC Cancer Agency, Vancouver
Registry updated 2026-11-05
NCT05174169
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
Trial Treatment · Phase 2/3 · NRG Oncology
Royal Victoria Regional Health Centre, Barrie · Arthur J.E. Child Comprehensive Cancer Centre, Calgary · Cambridge Memorial Hospital, Cambridge · CSSS Champlain-Charles Le Moyne, Greenfield Park · Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton · Kingston Health Sciences Centre, Kingston · Waterloo Regional Health Network, Kitchener · Hotel-Dieu de Levis, Lévis · London Regional Cancer Program, London · Markham Stouffville Hospital, Markham · Hopital Du Sacre Coeur de Montreal, Montreal · CIUSSSEMTL-Hopital Maisonneuve-Rosemont, Montreal · Jewish General Hospital, Montreal · Stronach Regional Health Centre at Southlake, Newmarket · Lakeridge Health Oshawa, Oshawa · Ottawa Hospital and Cancer Center-General Campus, Ottawa · BCCA-Cancer Centre for the North, Prince George · CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec · Allan Blair Cancer Centre, Regina · Niagara Health System-Saint Catharines General, Saint Catharines · Atlantic Health Sciences Corporation-Saint John Regional Hospital, Saint John · Saskatoon Cancer Centre, Saskatoon · Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke · Doctor H. Bliss Murphy Cancer Centre, St. John's · North York General Hospital, Toronto · Saint Michael's Hospital, Toronto · Humber River Hospital, Toronto · Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto · BCCA - Vancouver Cancer Centre, Vancouver · BCCA-Vancouver Island Cancer Centre, Victoria · Windsor Regional Cancer Centre, Windsor
Registry updated 2026-11-04
NCT06760819
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Trial Treatment · Phase 2 · Bayer
Queen Elizabeth II Health Sciences Centre | Oncology, Halifax · Research Institute of the McGill University Health Centre | Women Health's Research Unit, Montreal · Princess Margaret Cancer Centre | Medical Oncology and Hematology, Toronto
Registry updated 2026-11-04
NCT06997497
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
CIUSSS- saguenay-Lac-Saint-Jean (Site 0007), Chicoutimi · London Health Sciences Centre (Site 0012), London · Moncton Hospital - Horizon Health Network (Site 0011), Moncton · Jewish General Hospital (Site 0006), Montreal · Princess Margaret Cancer Centre (Site 0001), Toronto · Cancercare Manitoba (Site 0009), Winnipeg
Registry updated 2026-11-04
NCT07114601
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
Trial Treatment · Phase 1 · Eli Lilly and Company
Juravinski Cancer Centre, Hamilton · Lady Davis Institute for Medical Research Jewish General Hospital, Montreal · Princess Margaret Hospital, Toronto · Sunnybrook Health Sciences Centre, Toronto
Registry updated 2026-11-04
NCT05379595
A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer
Trial Treatment · Phase 1/2 · Janssen Research & Development, LLC
The Ottawa Hospital Cancer Centre, Ottawa · Princess Margaret Cancer Centre - University Health Network, Toronto · BC Cancer Agency - Vancouver BC, Vancouver
Registry updated 2026-11-03
NCT05673148
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial
Trial Treatment · Phase 2 · Alliance for Clinical Trials in Oncology
Arthur J.E. Child Comprehensive Cancer Centre, Calgary
Registry updated 2026-11-03
NCT06662786
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
Trial Treatment · Phase 3 · Janssen Research & Development, LLC
Arthur J.E. Child Comprehensive Cancer Centre, Calgary · Centre de Recherche du CHUM, Montreal · Ottawa Hospital, Ottawa · Princess Margaret Cancer Centre, Toronto
Registry updated 2026-11-03
NCT07284849
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Trial Treatment · Phase 3 · Incyte Corporation
Cross Cancer Institute, Edmonton · CISSS de la Monteregie-Centre, Greenfield Park · Juravinski Cancer Clinic, Hamilton · Hotel-Dieu de Levis, Lévis · Unite de Recherche Clinique Cisss Des Laurentides, Saint-Jérôme · Saskatoon Cancer Centre, Saskatoon · Sunnybrook Research Institute, Toronto · Princess Margaret Cancer Centre, Toronto
Registry updated 2026-10-30
NCT07387263
Mainstreaming Genetics: Evaluation of a Digital Application to Scale and Spread Oncologist-initiated Genetic Testing
Trial Treatment · Unity Health Toronto
Mount Sinai Hospital, Toronto · Sunnybrook Hospital, Toronto
Registry updated 2026-10-30
NCT06428409
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Trial Treatment · Phase 1/2 · Merck Sharp & Dohme LLC
Centre Hospitalier de l'Université de Montréal-Unit for Innovative Therapies (Site 0022), Montreal · McGill University Health Centre (Site 0023), Montreal · The Ottawa Hospital Cancer Centre (Site 0027), Ottawa
Registry updated 2026-10-29
NCT07516210
Adaptive Radiotherapy for Safe Hypofractionation
Trial Treatment · Phase 2 · Centre hospitalier de l'Université de Montréal (CHUM)
Centre Hospitalier de l'Université de Montréal, Montreal
Registry updated 2026-10-29
NCT04421820
BOLD-100 in Combination With FOLFOX With or Without Bevacizumab for the Treatment of Advanced, Solid Tumours
Trial Treatment · Phase 1/2 · Bold Therapeutics, Inc.
Cross Cancer Institue, Edmonton · Juravinski Cancer Centre, Hamilton · Jewish General Hospital, Montreal · McGill University Health Centre Glen Site, Montreal · The Ottawa Hospital Cancer Centre, Ottawa · Princess Margaret Cancer Centre, Toronto
Registry updated 2026-10-28
NCT05775146
SBRT of Metastases Following Neo-adjuvant Treatment for Colorectal Cancer With Synchronous Liver Metastases
Trial Treatment · Phase 2 · AHS Cancer Control Alberta
Cross Cancer Institute, Edmonton
Registry updated 2026-10-28
NCT04144907
Protein Needs Study
Trial Treatment · University of Alberta
University of Alberta, Edmonton
Registry updated 2026-10-27
NCT06820463
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
Trial Treatment · Phase 2 · AbbVie
Arthur J.E Child Comprehensive Cancer Centre /ID# 269809, Calgary · Cross Cancer Institute. /ID# 272711, Edmonton · London Health Sciences Centre - Victoria Hospital & Children's Hospital /ID# 270680, London · Universite de Montreal - Hopital Maisonneuve-Rosemont /ID# 271368, Montreal · Princess Margaret Cancer Centre /ID# 268715, Toronto
Registry updated 2026-10-27
NCT07221357
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Trial Treatment · Phase 2/3 · Bristol-Myers Squibb
Calgary · Halifax · Centre Hospitalier de l'Université de Montréal, Montreal · Jewish General Hospital, Montreal · Ottawa · Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke (CIUS, Sherbrooke · Toronto · Toronto
Registry updated 2026-10-23
NCT06004245
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
Trial Treatment · Phase 1 · Vividion Therapeutics, Inc.
Princess Margaret Cancer Center, Toronto · BCCA - Vancouver Cancer Centre, Vancouver
Registry updated 2026-10-21
NCT06885034
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)
Trial Treatment · Phase 1/2 · GlaxoSmithKline
Calgary · Montreal · Sherbrooke · Toronto
Registry updated 2026-10-19
NCT07261631
Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors
Trial Treatment · Phase 1 · Novartis Pharmaceuticals
Montreal
Registry updated 2026-10-09
NCT07222800
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
Trial Treatment · Phase 3 · Pfizer
Jewish General Hospital, Montreal · McGill University Health Centre, Montreal · Princess Margaret Cancer Centre, Toronto · Sunnybrook Research Institute, Toronto
Registry updated 2026-10-08

All Colorectal cancer trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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