Colorectal cancer: open trials in Portugal

16 open trials have a site in Portugal. Registry data; only the trial team decides who can take part.

NCT07262619
EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors
Trial Treatment · Phase 1/2 · Eikon Therapeutics
Hospital da Luz Lisboa, Lisbon · Hospital De Santa Maria, Lisbon · Unidade Local de Saúde (ULS) Loures Odivelas, Loures · Instituto Português de Oncologia do Porto Francisco Gentil, E.P.E. (IPO Porto), Porto
Registry updated 2026-10-30
NCT06330064
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Trial Treatment · Phase 1/2 · Daiichi Sankyo
Champalimaud Clinical Centre, Lisbon · Unidade Local De Saude De Santa Maria E.P.E., Lisbon · Instituto Portugues de Oncologia de Lisboa Francisco Gentil, E.P.E., Lisbon · Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E., Porto · Unidade Local De Saude De Santo Antonio E.P.E., Porto
Registry updated 2026-10-26
NCT07811193
A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum
Trial Treatment · Phase 2 · Vividion Therapeutics, Inc.
Unidade Local de Saúde de Coimbra, E.P.E. - Hospitais da Universidade de Coimbra - Serviço de Oncologia, Coimbra · START Research Portugal - ULSS Maria - Unidade de Ensaios de Fase I Start Lisbon, Lisbon · Unidade Local de Saúde de São José, E.P.E - Hospital de Santo António dos Capuchos - Serviço de Oncologia Médica, Lisbon · Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E. - Serviço de Oncologia Médica, Lisbon · Instituto Português de Oncologia do Porto Francisco Gentil, E.P.E. - Serviço de Oncologia Médica, Porto
Registry updated 2026-10-21
NCT07525206
A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer
Trial Treatment · Phase 3 · AbbVie
Unidade Local De Saude De Almada-Seixal E.P.E., Almada · Unidade Local De Saude Do Alto Ave E.P.E., Guimaraes · Unidade Local De Saude De Santa Maria E.P.E., Lisbon · Unidade Local De Saude De Loures-Odivelas EPE, Loures · Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E., Porto
Registry updated 2026-10-19
NCT06515821
Multicentre Study for Data Collection, Development, and Evaluation of Novel CRC Screening and Diagnostic Methods
Research · Firalis SA
IPO: Instituto Português de Oncologia, Porto
Registry updated 2026-09-16
2025-521702-18-00
A phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of [177Lu]Lu-DFC413 and safety and imaging properties of [68Ga]Ga-NNS309 in patients with solid tumors
Trial Treatment · Phase 1 · Novartis Pharma AG
Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E., Porto
Registry updated 2026-09-15
NCT06252649
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Trial Treatment · Phase 3 · Amgen
Unidade Local de Saude de Almada-Seixal, EPE - Hospital Garcia de Orta, Almada · Instituto Portugues de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra · Unidade Local de Saude de Coimbra, EPE, Coimbra · Hospital da Luz, SA, Lisbon · Unidade Local de Saude de Santa Maria EPE - Hospital de Santa Maria, Lisbon · Hospital Cuf Tejo, Lisbon · Fundacao Champalimaud, Lisbon · Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano, Matosinhos Municipality · Unidade Local de Saude de Entre Douro e Vouga, EPE - Hospital de Sao Sebastiao, Santa Maria da Feira
Registry updated 2026-09-03
2022-502352-31-00
Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Subjects With Metastatic Colorectal Cancer With KRAS p.G12C Mutation (CodeBreaK 301)
Trial Treatment · Phase 3 · Amgen Inc.
Unidade Local De Saude De Almada-Seixal E.P.E., Almada · Instituto Portugues De Oncologia Coimbra Francisco Gentil E.P.E., Coimbra · Unidade Local de Saúde de Coimbra, E.P.E., Coimbra · Champalimaud Clinical Centre, Lisbon · Unidade Local De Saude De Santa Maria E.P.E., Lisbon · Hospital da Luz, S.A, Lisbon · Hospital Cuf Tejo S.A., Lisbon · Unidade Local De Saude De Entre O Douro E Vouga E.P.E., Santa Maria Da Feira · Unidade Local De Saude De Matosinhos E.P.E., Senhora Da Hora
Registry updated 2026-07-30
NCT05253651
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Trial Treatment · Phase 3 · Seagen, a wholly owned subsidiary of Pfizer
Unidade Local De Saude De Almada-Seixal E.P.E., Almada · Unidade Local De Saude Da Guarda E.P.E., Guarda · Champalimaud Clinical Centre, Lisbon · Unidade Local De Saude De Santo Antonio E.P.E., Porto
Registry updated 2026-07-22
NCT06741293
Improving Colorectal Cancer Early Screening in Portugal: Identification of Gut Microbiome Biomarkers in Stool (GUTBIOME-PT)
Research · Gulbenkian Institute for Molecular Medicine
Gulbenkian Institute for Molecular Medicine, Lisbon
Registry updated 2026-05-14
NCT06734156
CARE-CRC: Microbiome Insights and Correlations for Risk and Outcomes in Colorectal Cancer
Research · Gulbenkian Institute for Molecular Medicine
Gulbenkian Institute for Molecular Medicine, Lisbon · Champalimaud Foundation, Lisbon
Registry updated 2026-05-12
NCT05855200
Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
Trial Treatment · Phase 3 · GlaxoSmithKline
Unidade Local De Saude De Almada-Seixal E.P.E., Almada · Unidade Local de Saúde de Coimbra, E.P.E., Coimbra · Hospital De Santa Maria E.P.E., Lisbon
Registry updated 2026-01-23
NCT06696534
Exploring Participant Preference for Screening Methods and Experience Into Colorectal Cancer Screening Programme
Trial Treatment · ADVANCED MARKER DISCOVERY S.L.
UCSP Sete Rios, Lisbon
Registry updated 2025-10-02
NCT06972160
Intervention Project to Increase Adherence to Colorectal Cancer Screening in Barcelos/Esposende
Trial Treatment · Local Health Unit Barcelos/Esposende, Public Health Unit
Public Health Unit Barcelos/Esposende, Porto
Registry updated 2025-05-14
NCT06703632
Evaluation of PreveCol's Efficiency As a Second Line Method for the Early Colorectal Cancer Detection
Trial Treatment · ADVANCED MARKER DISCOVERY S.L.
Hospital De Santa Maria, Lisbon
Registry updated 2025-02-27
NCT04389086
Induction Chemotherapy for Locally Recurrent Rectal Cancer
Trial Treatment · Phase 3 · Catharina Ziekenhuis Eindhoven
Instituto Portugues de Oncologia de Lisboa Francisco Gentil, E.P.E., Lisbon
Registry updated 2022-09-06

All Colorectal cancer trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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