Diffuse large B-cell lymphoma: open trials in United States

• NCT05887167

  Feasibility and Safety of Collecting and Combining Autologous Hematopoietic Stem Cells With Chimeric Antigen Receptor (CAR) T-Cell Therapy in Subjects With Relapsed/Refractory Hematological Malignancies

  Trial Treatment · Phase 1 · Joshua Sasine, MD, PhD

  Cedars-Sinai Medical Center, Los Angeles

  Registry updated 2026-08-10

• NCT05990465

  LV20.19 CAR T-Cells in Combination With Pirtobrutinib for Relapsed, Refractory B-cell Malignancies

  Trial Treatment · Phase 1 · Medical College of Wisconsin

  Froedtert & the Medical College of Wisconsin, Milwaukee

  Registry updated 2026-08-06

• NCT07750886

  Sample Collection for Ongoing Research and Product Evaluation Study - Non-Hodgkin Lymphoma (SCORE-NHL)

  Research · Natera, Inc.

  Natera, Inc., Austin

  Registry updated 2026-08-06

• NCT06116110

  Lentiviral Gene Therapy (Zamtocabtagene Autoleucel) LTFU

  Research · Miltenyi Biomedicine GmbH

  University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore · Dana-Farber Cancer Institute, Boston · Robert H Lurie Cancer Center, Chicago · UT Southwestern Medical Center, Dallas · Duke University Medical Center - Division of Hematologic Malignancies, Durham · Banner MD Anderson Cancer Center, Gilbert · Froedtert Hospital and the Medical College of Wisconsin, Milwaukee · Yale University, New Haven · Oregon Health and Science University Knight Cancer Institute, Portland · Stanford University, Stanford · University of Kansas Cancer Center, Westwood

  Registry updated 2026-08-05

• NCT07748364

  Glofitamab in B-NHL Using Mid-Therapy Intratumoral Transcriptomics

  Trial Treatment · Phase 2 · Joshua Brody

  Icahn School of Medicine at Mount Sinai, New York

  Registry updated 2026-08-05

• NCT07729397

  Autologous IC-Nine, CD30 CAR, and Constitutive IL7R Expressing EBVST for CD30 Lymphoma (ANCILE-30)

  Trial Treatment · Phase 1 · The Methodist Hospital Research Institute

  Houston Methodist Hospital, Houston

  Registry updated 2026-07-27

• NCT07121946

  This is a Phase 1 Study to Evaluate the Safety of LTZ-301 in Patients With Non-Hodgkin Lymphoma

  Trial Treatment · Phase 1 · LTZ Therapeutics, Inc.

  Roswell Park Cancer Institute, Buffalo · City of Hope, Duarte · Tennessee Oncology, Nashville · Memorial Sloan Kettering Cancer Center - Bergen, New York · Fred Hutchinson Cancer Center, Seattle · Washington University School of Medicine, St Louis

  Registry updated 2026-07-24

• NCT07714421

  Epcoritamab and Pola-R-mini-CHP for the Treatment of Diffuse Large B Cell Lymphoma in Elderly or Unfit Patients

  Trial Treatment · Phase 1 · Jonsson Comprehensive Cancer Center

  UCLA / Jonsson Comprehensive Cancer Center, Los Angeles

  Registry updated 2026-07-20

• NCT07164469

  Phase 2 Trial of CD70.CAR NK Cells for Patients With Primary Refractory or Early Relapsed Diffuse Large B-Cell Lymphoma and Hodgkin Lymphoma

  Trial Treatment · Phase 2 · M.D. Anderson Cancer Center

  The University of Texas M. D. Anderson Cancer Center, Houston

  Registry updated 2026-07-15

• NCT04792489

  DALY II USA/ MB-CART2019.1 for DLBCL

  Trial Treatment · Phase 2 · Miltenyi Biomedicine GmbH

  University of Michigan, Ann Arbor · Winship Cancer Institute of Emory University, Atlanta · Georgia Cancer Center at Augusta University, Augusta · University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore · University of Alabama at Birmingham, Birmingham · Dana-Farber Cancer Institute, Boston · Robert H Lurie Cancer Center, Chicago · The Ohio State University Wexner Medical Center James Cancer, Columbus · UT Southwestern Medical Center, Dallas · Colorado Blood Cancer Institute, Denver · Duke University Medical Center - Division of Hematologic Malignancies, Durham · Banner MD Anderson Cancer Center, Gilbert · The University of Texas MD Anderson Cancer Center, Houston · UC San Diego Health, La Jolla · Baptist Health Miami Cancer Institute, Miami · Froedtert Hospital and the Medical College of Wisconsin, Milwaukee · SCRI Oncology Partners, Nashville · Yale University, New Haven · Memorial Sloan-Kettering Cancer Center, New York · University of Nebraska Medical Center, Omaha · Mayo Clinic, Phoenix · University of Pittsburgh Hillman Cancer Center, Pittsburgh · Allegheny Health Network Cancer Institute, Pittsburgh · Oregon Health and Science University Knight Cancer Institute, Portland · Mayo Clinic, Rochester · Texas Transplant Institute, San Antonio · Fred Hutchinson Cancer Center, Seattle · Stanford University, Stanford · Washington University St. Louis, St Louis · University of Kansas Cancer Center, Westwood

  Registry updated 2026-07-13

• NCT05077527

  Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma

  Trial Treatment · Phase 1 · AIDS Malignancy Consortium

  University of Illinois at Chicago, Chicago · The Ohio State University, Columbus · City of Hope Comprehensive Cancer Center, Duarte · Memorial Sloan-Kettering Cancer Center, New York · University of Pennsylvania/Abramson Cancer Center, Philadelphia · Huntsman Cancer Institute/University of Utah, Salt Lake City · Montefiore Medical Center - Moses Campus, The Bronx

  Registry updated 2026-07-10

• NCT06854159

  Odronextamab for the Treatment of Relapsed and Refractory Diffuse Large B-cell Lymphoma Before and After Chimeric Antigen Receptor T-cell Therapy

  Trial Treatment · Phase 2 · University of California, Davis

  University of California Davis Comprehensive Cancer Center, Sacramento

  Registry updated 2026-07-08

• NCT06249191

  Mosunetuzumab With Chemotherapy for the Treatment of Patients With Untreated C-Myc Rearrangement Positive High Grade B Cell Lymphoma or Diffuse Large B Cell Lymphoma

  Trial Treatment · Phase 1/2 · OHSU Knight Cancer Institute

  OHSU Knight Cancer Institute, Portland

  Registry updated 2026-07-07

• NCT03501576

  Evaluation of Human Immune Responses Vaccination in Patients With Lymphoma

  Research · Emory University

  Emory University Hospital Midtown, Atlanta · Emory University Hospital/Winship Cancer Institute, Atlanta

  Registry updated 2026-07-06

• NCT05131022

  A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

  Trial Treatment · Phase 1 · Nurix Therapeutics, Inc.

  Winship Cancer Institute of Emory University, Atlanta · National Institute Of Health, Bethesda · Northwestern University, Chicago · University of Cincinnati Medical Center, Cincinnati · Cleveland Clinic, Cleveland · Colorado Blood Cancer Institute, Denver · City of Hope, Duarte · Duke University Medical Center, Durham · MD Anderson Cancer Center, Houston · Cayuga Medical Center, Ithaca · University of Miami, Miami · Medical College of Wisconsin, Milwaukee · Yale Cancer Center, New Haven · Memorial Sloan-Kettering Cancer Center, New York · University of Pennsylvania/Abramson Cancer Center, Philadelphia · Huntsman Cancer Institute, Salt Lake City · University of California San Francisco, San Francisco · Florida Cancer Specialists, Sarasota

  Registry updated 2026-07-02

• NCT07478848

  Radiation, Oral Vancomycin, and CAR-T for B-Cell Lymphomas

  Trial Treatment · Phase 1 · Abramson Cancer Center at Penn Medicine

  Abramson Cancer Center, University of Pennsylvania, Philadelphia

  Registry updated 2026-07-01

• NCT06905509

  Epcoritamab Plus Standard of Care Platinum-Based Chemotherapy and Autologous Hematopoietic Cell Transplant for the Treatment of Relapsed or Refractory Large B-cell Lymphoma

  Trial Treatment · Phase 2 · University of California, Davis

  University of California Davis Comprehensive Cancer Center, Sacramento

  Registry updated 2026-06-30

• NCT01137825

  Registry of Older Patients With Cancer

  Research · UNC Lineberger Comprehensive Cancer Center

  Seby B. Jones Cancer Center, Boone · Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, Chapel Hill · East Carolina University, Greenville · Pardee Cancer Center, Hendersonville · Carteret Health Care Cancer Center, Morehead City · Carolina East Radiology, New Bern · Rex Healthcare, Raleigh

  Registry updated 2026-06-29

• NCT06898905

  Hyperfractionated Dual Equivalent Fractionated Radiation Therapy

  Trial Treatment · Yale University

  Yale University, New Haven

  Registry updated 2026-06-22

• NCT07528352

  External Beam Radiotherapy Followed by Bispecific Antibody Therapy for Relapsed/Refractory DLBCL

  Trial Treatment · Phase 1 · University of Utah

  Huntsman Cancer Institute at University of Utah, Salt Lake City

  Registry updated 2026-06-04

• NCT06458439

  Epcoritamab-CAR T Cells for Large B-cell Lymphomas

  Trial Treatment · Phase 2 · Abramson Cancer Center at Penn Medicine

  Abramson Cancer Center at the University of Pennsylvania, Philadelphia

  Registry updated 2026-05-27

• NCT06768905

  IOMAB-CAR-T Followed by CAR-T Cell Therapy in R/R DLBCL

  Trial Treatment · Phase 1/2 · University of Texas Southwestern Medical Center

  University of Texas Southwestern Medical Center, Dallas

  Registry updated 2026-05-08

• NCT06859008

  Zanubrutinib in Combination With Sonrotoclax for the Treatment of Underrepresented Ethnic and Racial Minorities With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

  Trial Treatment · Phase 1 · City of Hope Medical Center

  City of Hope Medical Center, Duarte

  Registry updated 2026-04-20

• NCT04329728

  The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies

  Trial Treatment · Phase 1/2 · AVM Biotechnology Inc

  Gabrail Cancer Center Research, Canton · University of Illinois at Chicago Cancer Center, Chicago · University of Texas(UT) Southwestern-Children's Medical Center, Dallas · City of Hope, Duarte · Los Angeles Cancer Network, Los Angeles · UCLA Medical Center of Hematology/Oncology, Los Angeles · Norton Cancer Institute, Louisville · Baptist Clinical Research Institute, Memphis · Oncology Hematology West P.C. dba Nebraska Cancer Specialists, Omaha · ASCLEPES Research Centers, Weeki Wachee · Innovative Clinical Research Institute, Whittier

  Registry updated 2026-04-15

• NCT04491370

  Autologous Stem Cell Transplant Followed by Polatuzumab Vedotin in Patients With B-cell Non-Hodgkin and Hodgkin Lymphoma

  Trial Treatment · Phase 1/2 · New York Medical College

  New York Medical Center, Valhalla

  Registry updated 2026-04-15

All Diffuse large B-cell lymphoma trials and the map

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