Epilepsy: open trials in Spain

21 open trials have a site in Spain. Registry data; only the trial team decides who can take part.

NCT05667142
A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
Trial Treatment · Phase 3 · Xenon Pharmaceuticals Inc.
Hospital Universitario 12 de Octubre, Madrid
Registry updated 2026-11-02
NCT05716100
A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
Trial Treatment · Phase 3 · Xenon Pharmaceuticals Inc.
Biocruces Bizkaia Health Research Institute, Barakaldo · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Clínico San Carlos, Madrid · Hospital Universitario Ramón y Cajal, Madrid
Registry updated 2026-11-02
NCT05718817
An Open-label Study of XEN1101 in Epilepsy
Trial Treatment · Phase 3 · Xenon Pharmaceuticals Inc.
Biocruces Bizkaia Health Research Institute, Barakaldo · Hospital Universitari Vall d'Hebron, Barcelona · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Clínico San Carlos, Madrid · Hospital Blua Sanitas Valdebebas, Madrid · Hospital Ruber Internacional, Madrid · Hospital Universitario Ramón y Cajal, Madrid · Hospital La Milagrosa S.A., Madrid · Hospital Universitario 12 de Octubre, Madrid · Hospital Universitario Regional de Málaga, Málaga · Hospital Universitario Y Politecnico La Fe, Valencia · Hospital Clínico Universitario de Valladolid, Valladolid
Registry updated 2026-11-02
2025-521640-38-00
Open Label Extension Clinical Trial of Vormatrigine in Adult Patients with Epilepsy.
Trial Treatment · Phase 3 · Praxis Precision Medicines Inc.
Hospital Universitari Vall d'Hebron, Barcelona · Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital Clinic de Barcelona, Barcelona · Hospital del Mar, Barcelona · Hospital Vithas La Salud, Granada · Hospital Universitario Virgen de las Nieves, Granada · Hospital Universitario Lucus Augusti, Lugo · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Blua Sanitas Valdebebas, Madrid · Hospital Universitario de la Princesa, Madrid · Hospital Clínico San Carlos, Madrid · Hospital La Milagrosa S.A., Madrid · Hospital Universitario Regional de Málaga, Málaga · Complexo Hospitalario Universitario De Santiago, Santiago de Compostela · Centro De Neurologia Avanzada S.L.P., Sevilla · Fundacio Assistencial De Mutua De Terrassa Fpc, Terrassa · Hospital Universitario Y Politecnico La Fe, Valencia · Hospital Clínico Universitario de Valladolid, Valladolid
Registry updated 2026-10-29
NCT04462770
A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
Trial Treatment · Phase 3 · Epygenix
Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital Infantil Universitario Nino Jesus, Madrid
Registry updated 2026-10-29
NCT07881185
Artificial Intelligence for Brain MRI Analysis in Epilepsy
Research · Istituto Giannina Gaslini
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona
Registry updated 2026-10-19
NCT06908226
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)
Trial Treatment · Phase 3 · Longboard Pharmaceuticals
Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital Universitari Vall d'Hebron, Barcelona · Hospital Sant Joan de Deu Barcelona (HSJDB), Esplugues de Llobregat · Hospital Ruber Internacional, Madrid · Hospital Universitario Vithas Madrid La Milagrosa, Madrid · Hospital Infantil Universitario Nino Jesus (HIUNJS), Madrid · Hospital Regional Universitario de Malaga - Hospital General, Málaga · Hospital Universitario de Navarra, Pamplona · Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur), Valencia
Registry updated 2026-10-14
2024-514499-42-00
Efficacy and Safety Study of Once-Daily Extended-Release Levetiracetam in Drug-resistant Focal Onset Seizures
Trial Treatment · Phase 3 · Neuraxpharm Pharmaceuticals S.L.
Hospital del Mar, Barcelona · Hospital Universitario 12 de Octubre, Madrid · Hospital La Milagrosa S.A., Madrid · Hospital Universitario Regional de Málaga, Málaga · Complexo Hospitalario Universitario De Santiago, Santiago de Compostela
Registry updated 2026-10-13
NCT05066217
An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome
Trial Treatment · Phase 3 · Epygenix
Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital Universitario Vall d'Hebron - PPDS, Barcelona · Hospital Infantil Universitario Niño Jesus - PIN, Madrid · Hospital Regional Universitario de Malaga - Hospital General, Málaga · Hospital Universitario de Navarra, Pamplona · Centro de Neurologia Avanzada, Seville
Registry updated 2026-10-09
NCT07775872
Prospective Natural History Study of POLG Disease
Research · The POLG Foundation
Hospital 12 de Octubre- Madrid, Madrid
Registry updated 2026-09-15
NCT07287163
Clinical Trial of Vormatrigine in Adult Patients With Epilepsy
Trial Treatment · Phase 3 · Praxis Precision Medicines
Praxis Research Site, Barcelona · Praxis Research Site, Madrid · Praxis Research Site, Málaga · Praxis Research Site, Terrassa · Praxis Research Site, Valencia
Registry updated 2026-08-03
NCT04715646
A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures
Trial Treatment · Phase 3 · UCB Biopharma SRL
Ep0156 248, Seville
Registry updated 2026-07-27
NCT06138808
5-SENSE Score Validation Study
Research · Duke University
Hospital Universitario Y Politecnico La Fe, Valencia
Registry updated 2026-06-05
NCT06443463
Long-term Safety and Tolerability of BHV-7000
Trial Treatment · Phase 2 · Biohaven Therapeutics Ltd.
Hospital Germans Trias i Pujol, Badalona · Hospital del Mar, Barcelona · Hospital Universitari Vall d'Hebron, Barcelona · Hospital Universitario Virgen de las Nieves, Granada · Hospital Universitario Clínico San Cecilio, Granada · Hospital Vithas La Salud, Granada · Bellvitge University Hospital, L'hospitalet De Llobregat · Hospital Ruber Internacional, Madrid · Hospital Blua Sanitas Valdebebas, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Universitario Regional de Málaga, Málaga · Hospital Universitario de Navarra, Pamplona · Centro De Neurologia Avanzada S.L.P., Sevilla · Fundacio Assistencial De Mutua De Terrassa Fpc, Terrassa · Hospital Universitario Y Politecnico La Fe, Valencia · Hospital Clínico Universitario de Valladolid, Valladolid · Hospital Alvaro Cunqueiro, Vigo
Registry updated 2026-05-01
NCT07403266
Treatment With Full-spectrum Cannabis Extract of Refractory Epilepsy Associated With Tuberous Sclerosis Complex (TSC)
Trial Treatment · Phase 3 · Oils4Cure
Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital Universitario 12 de Octubre, Madrid · Hospital Ruber Internacional, Madrid
Registry updated 2026-02-11
NCT07234695
LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome
Trial Treatment · Phase 3 · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Hospital de la Santa Creu i Sant Pau, Barcelona · Fundacion CITA Alzheimer, Donostia · Hospital Universitario Virgen de las Nieves, Granada · Hospital Universitario de la Princesa, Madrid · Hospital Universitario Marqués de Valdecilla, Santander
Registry updated 2026-01-12
NCT06922175
REACH: RWE Retrospective Study to Evaluate Cenobamate Impact on Health Care Resource Utilization
Research · Aziende Chimiche Riunite Angelini Francesco S.p.A
Epilepsy Unit - Neurology Department Valle de Hebron Hospital, Barcelona · Epilepsy Unit of the Neurology Department of the Hospital Clínico San Carlos, Madrid · Consorcio Hosp. General Universitario Valencia, Valencia
Registry updated 2025-10-02
NCT05219617
Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults
Trial Treatment · Phase 3 · SK Life Science, Inc.
Hospital Sant Joan de Deu - PIN, Esplugues de Llobregat · Hospital Ruber Internacional (Grupo Quironsalud), Madrid · Hospital Infantil Universitario Niño Jesus - PIN, Madrid
Registry updated 2025-07-24
NCT06908356
An Open Label Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adults With Focal Onset or Tonic-Clonic Seizures
Trial Treatment · Phase 2 · Praxis Precision Medicines
Praxis Research Site, Madrid
Registry updated 2025-04-03
2024-520427-86-00
Phase I, open-label clinical trial to evaluate the safety and clinical response of repeated-dose intra-arterial infusion of autologous mesenchymal cells in children and adolescents with refractory epilepsies.
Trial Treatment · Phase 1 · Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Princesa
Hospital Infantil Universitario Nino Jesus, Madrid
Registry updated 2025-01-24
NCT06356233
Phenotyping and Identification of Biological Markers in STXBP1 Encephalopathy
Research · Fundación Iniciativa para las Neurociencias (FINCE)
Hospital Ruber Internacional, Madrid
Registry updated 2024-04-10

All Epilepsy trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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