Glioblastoma: open trials in Canada

• NCT04765098

  Tamoxifen Versus Etoposide After First Recurrence in GBM Patients

  Trial Treatment · Phase 2 · AHS Cancer Control Alberta

  Cross Cancer Institute, Edmonton

  Registry updated 2026-11-04

• NCT03970447

  A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

  Trial Treatment · Phase 2/3 · Global Coalition for Adaptive Research

  Montreal Neurological Institute and Hospital, McGill University, Montreal · Université de Sherbrooke, Sherbrooke · Sunnybrook Health Sciences Centre, Toronto · Princess Margaret Cancer Centre, Toronto

  Registry updated 2026-11-02

• NCT05432518

  Pilot Trial for Treatment of Recurrent Glioblastoma

  Trial Treatment · Early phase 1 · AHS Cancer Control Alberta

  Arthur J.E. Child Comprehensive Cancer Centre, Calgary

  Registry updated 2026-10-28

• NCT07459101

  UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-4

  Trial Treatment · Sunnybrook Health Sciences Centre

  Sunnybrook Health Sciences Centre - Odette Cancer Centre, Toronto

  Registry updated 2026-10-23

• NCT04094610

  A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

  Trial Treatment · Phase 1/2 · Turning Point Therapeutics, Inc.

  University Of Calgary, Calgary · Stollery Children'S Hospital, Edmonton · St Justine Hospital, Montreal · Children'S Hospital Of Eastern Ontario, Ottawa

  Registry updated 2026-09-25

• NCT05839379

  Targeted Pediatric High-Grade Glioma Therapy

  Research · Nationwide Children's Hospital

  Montreal Children's Hospital, Montreal · The Hospital for Sick Children (SickKids), Toronto

  Registry updated 2026-09-08

• NCT06161974

  Study of Olutasidenib and Temozolomide in HGG

  Trial Treatment · Phase 2 · Rigel Pharmaceuticals

  Montreal Children's Hospital, Montreal · The Hospital for Sick Children (SickKids), Toronto

  Registry updated 2026-09-01

• NCT06850766

  The Feasibility and Efficacy of Dose Timing (Morning vs Evening) of Temozolomide in the Treatment of Glioblastoma

  Trial Treatment · Ottawa Hospital Research Institute

  London Health Sciences Centre, London · The Ottawa Hospital Cancer Centre, Ottawa

  Registry updated 2026-07-16

• NCT06333899

  Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

  Trial Treatment · Early phase 1 · Nationwide Children's Hospital

  Montreal Children's Hospital, Montreal · The Hospital for Sick Children (SickKids), Toronto

  Registry updated 2026-06-29

• NCT05116137

  The Impact of Resistance ExerciSe on Muscle Mass in GlioblaSToma Survivors

  Trial Treatment · Nova Scotia Health Authority

  QEII Health Sciences Centre, Halifax

  Registry updated 2026-05-29

• NCT05843253

  Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

  Trial Treatment · Phase 2 · Nationwide Children's Hospital

  Montreal Children's Hospital, Montreal · The Hospital for Sick Children (SickKids), Toronto

  Registry updated 2026-05-29

• NCT07476794

  Daily Temozolomide for Elderly Patients With Unmethylated MGMT- Promoter Newly Diagnosed GliOblatoma

  Trial Treatment · Phase 2 · Sunnybrook Health Sciences Centre

  Sunnybrook Health Sciences Centre, Toronto

  Registry updated 2026-03-17

• NCT05941507

  A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

  Trial Treatment · Phase 1/2 · LigaChem Biosciences, Inc.

  Princess Margaret Cancer Centre, Toronto

  Registry updated 2025-09-24

• NCT07179328

  Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy

  Trial Treatment · Phase 1 · Sunnybrook Health Sciences Centre

  Sunnybrook Health Sciences Centre, Toronto

  Registry updated 2025-09-17

• NCT03672721

  IA Carboplatin + Radiotherapy in Relapsing GBM

  Trial Treatment · Phase 1/2 · Université de Sherbrooke

  CHUS, Sherbrooke

  Registry updated 2025-08-11

• NCT06356883

  Intraarterial Carboplatin + Caelyx vs Intraarterial Carboplatin + Etoposide Phosphate for Progressing Glioblastoma

  Trial Treatment · Phase 2 · Université de Sherbrooke

  CHUS, Sherbrooke

  Registry updated 2025-08-07

• NCT03175224

  APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

  Trial Treatment · Phase 2 · Apollomics Inc.

  Cross Cancer Institute, Edmonton · McGill University Health Center - Research Institute, Montreal · Princess Margaret Hospital, Toronto · Cancer Care Manitoba, Winnipeg

  Registry updated 2025-06-27

• NCT05326334

  THERApeutic Outcomes Related to Gut microBIOME in Glioblastoma (GBM) Patients Receiving Chemo-radiation (THERABIOME-GBM)

  Research · Ottawa Hospital Research Institute

  The Ottawa Hospital Cancer Centre, Ottawa

  Registry updated 2023-04-18

All Glioblastoma trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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