Lung cancer: open trials in United Kingdom

149 open trials have a site in United Kingdom. Registry data; only the trial team decides who can take part.

NCT05384626
A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)
Trial Treatment · Phase 1/2 · Nuvalent Inc.
Edinburgh Cancer Centre, Edinburgh · The Royal Marsden - Chelsea, London · The Christie NHS Foundation Trust, Manchester · Royal Marsden Hospital, Sutton
Registry updated 2026-11-06
NCT05920356
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
Trial Treatment · Phase 3 · Amgen
Queen Elizabeth Hospital Birmingham, Birmingham · Raigmore Hospital, Inverness · Royal Marsden Hospital, London · Mount Vernon Cancer Centre, Northwood · Torbay Hospital, Torquay · Royal Cornwall Hospital, Truro
Registry updated 2026-11-06
NCT06284317
A Study to Evaluate the Benefit of Adding Durvalumab After Chemotherapy, Durvalumab and Surgery in Patients With Early-stage, Operable, Non-small Cell Lung Cancer.
Trial Treatment · Phase 3 · ETOP IBCSG Partners Foundation
Velindre University NHS Trust, Cardiff · Beatson West of Scotland Cancer Centre - NHS Greater Glasgow and Clyde, Glasgow · Royal Marsden Hospital (Sutton), London · Royal Marsden Hospital (Chelsea), London · Barts Health NHS Trust, London · Maidstone and Tunbridge Wells NHS Trust, Maidstone · Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester
Registry updated 2026-11-06
NCT06881784
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
Trial Treatment · Phase 3 · Revolution Medicines, Inc.
Birmingham Heartlands Hospital, Birmingham · The Clatterbridge Cancer Centre, Liverpool · Royal Free Hospital, London · Barts Hospital, London · University College London Hospital, London · Royal Marsden Hospital - London, London · The Christie NHS Foundation Trust, Manchester · Nottingham University Hospitals City Campus, Nottingham · Royal Marsden Hospital (Sutton), Sutton
Registry updated 2026-11-06
NCT07284121
A Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants Treated in Routine Clinical Practice
Research · Hoffmann-La Roche
University Hospitals Birmingham NHS Foundation Trust, Birmingham · Royal Surrey County Hospital, Guildford · Leeds Teaching Hosp NHS Trust, Leeds · James Cook University Hospital, Middlesbrough · James Paget University Hospitals NHS Foundation Trust, Norfolk
Registry updated 2026-11-06
NCT05789082
A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
Trial Treatment · Phase 1/2 · Hoffmann-La Roche
Beatson West of Scotland Cancer Centre, Glasgow · Barts & London School of Med, London
Registry updated 2026-11-05
NCT06793215
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
Trial Treatment · Phase 3 · Hoffmann-La Roche
Blackpool Teaching Hospitals NHS Foundation Trust , Victoria Hospital, Blackpool · Bristol Haematology & Oncology Centre, Bristol · East Kent Hospitals University NHS Foundation Trust, Canterbury · Velindre NHS Trust, Velindre Cancer Centre, Cardiff · Hull University Teaching Hospitals NHS Trust, Hull · Barts and the London NHS Trust, London · Sarah Cannon Research Institute, London · Royal Marsden Hospital - Fulham, London · Maidstone and Tunbridge Wells NHS Trust, Maidstone · Oxford University Hospitals NHS Trust - Churchill Hospital, Oxford · University Hospitals of North Midlands NHS Trust - Royal Stoke University Hospital, Stoke-on-Trent · Royal Marsden NHS Foundation Trust, Sutton
Registry updated 2026-11-05
NCT07090499
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
Trial Treatment · Phase 1 · Pfizer
Barts Cancer Centre at St. Bartholomew's Hospital; Queen Mary University of London, London · The Christie NHS Foundation Trust, Manchester
Registry updated 2026-11-05
NCT07144280
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
Trial Treatment · Phase 3 · Pfizer
Sarah Cannon Research Institute UK, London · Barts Health NHS Trust , The Royal London Hospital, London · St. Bartholomew's Hospital, London · The Christie NHS Foundation Trust, Manchester
Registry updated 2026-11-05
NCT07361497
A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
Trial Treatment · Phase 3 · Bristol-Myers Squibb
Birmingham · Addenbrooke's Hospital, Cambridge · Velindre Cancer Centre, Cardiff · The Royal Surrey County Hospital NHS Foundation Trust, Guildford · Leeds · Clatterbridge Cancer Centre - Liverpool, Liverpool · University College London Hospital, London · Royal Marsden Hospital (Chelsea), London · The Christie NHS Foundation Trust, Manchester · Mount Vernon Hospital, Middlesex · Newcastle upon Tyne · The Royal Marsden NHS Foundation Trust, Sutton
Registry updated 2026-11-05
NCT07491497
A Phase 1/2 Study of TRI-611 in ALK-Positive NSCLC
Trial Treatment · Phase 1/2 · TRIANA Biomedicines, Inc.
The Royal Marsden NHS Foundation, Sutton
Registry updated 2026-11-05
NCT07563738
A 2-part Phase 1/2 Open-label Trial on ODM-212
Trial Treatment · Phase 1/2 · Orion Corporation, Orion Pharma
Leicester Royal Infirmary, Leicester · Royal Marsden Hospital, London · University Hospital Southampton, Southampton
Registry updated 2026-11-05
NCT06119581
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Trial Treatment · Phase 3 · Eli Lilly and Company
Aberdeen Royal Infirmary, Aberdeen · Ninewells Hospital and Medical School, Dundee · Huddersfield Royal Infirmary, Huddersfield · St James's University Hospital, Leeds · The Christie NHS Foundation Trust, Manchester · Mount Vernon Hospital, Northwood · Weston Park Hospital, Sheffield · New Cross Hospital, Wolverhampton
Registry updated 2026-11-04
NCT06452277
A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Trial Treatment · Phase 3 · Bayer
Belfast City Hospital | Oncology, Belfast · Velindre Cancer Centre | Clinical Trials Unit, Cardiff · Royal Surrey County Hospital | Cancer Centre, Guildford · Torbay Hospital | Oncology, Torquay
Registry updated 2026-11-04
NCT06465069
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
Trial Treatment · Phase 1 · Eli Lilly and Company
St. Bartholomew's Hospital, London · The Christie NHS Foundation Trust, Manchester
Registry updated 2026-11-04
NCT06890598
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
Trial Treatment · Phase 3 · Eli Lilly and Company
Heartlands Hospital, Birmingham · University Hospitals Sussex NHS Foundation Trust, East Sussex · Huddersfield Royal Infirmary, Huddersfield · Royal Marsden Hospital (Sutton), London · Royal Marsden Hospital (Chelsea), London · The Christie NHS Foundation Trust, Manchester · Torbay Hospital, Torquay
Registry updated 2026-11-04
NCT05498428
A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
Trial Treatment · Phase 2 · Janssen Research & Development, LLC
Cheltenham General Hospital, Cheltenham · Torbay Hospital-Devon, Devon · Edinburgh Cancer Centre Western General, Edinburgh · Leicester Royal Infirmary, Leicester · University College London Hospitals, London · Nottingham City Hospital, Nottingham · Queen Alexandra Hospital, Portsmouth
Registry updated 2026-11-03
NCT06170788
Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Kent and Canterbury Hospital-Oncology Research (Site 2606), Canterbury · James Cook University Hospital (Site 2604), Central Middlesbrough · Royal Free Hospital (Site 2601), London · Guy's & St Thomas' NHS Foundation Trust-Oncology & Haematology Clinical Trials (Site 2605), London · Queen Alexandra Hospital-Oncology Department (Site 2603), Portsmouth
Registry updated 2026-11-03
NCT06303505
FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC
Trial Treatment · Phase 1/2 · Gilead Sciences
Guy's Hospital, London
Registry updated 2026-11-03
NCT06667076
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Trial Treatment · Phase 2 · Janssen Research & Development, LLC
Guy's and St Thomas' NHS Foundation Trust, Greater London · The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool · Royal Marsden Hospital 1, London · The Christie NHS Foundation Trust - Christie Hospital, Manchester · Royal Marsden Hospital, Sutton · Torbay Hospital-Devon, Torquay
Registry updated 2026-11-03
NCT06667908
A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)
Trial Treatment · Phase 2 · Johnson & Johnson Enterprise Innovation Inc.
University College London Hospitals, London
Registry updated 2026-11-03
NCT07230691
A Study of Clinical Outcomes in Participants With EGFR Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) in a Real-World Setting
Research · Janssen Research & Development, LLC
Royal United Hospital, Bath · Velindre Hospital, Cardiff · Eastbourne District General Hospital, Eastbourne · Royal Surrey County Hospital NHS Trust, Guildford · New Cross Hospital, Heath Town · Royal Marsden Hospital, London · The Christie NHS Foundation Trust - Christie Hospital, Manchester · Royal Marsden Hospital (Sutton), Sutton
Registry updated 2026-11-03
NCT06712316
Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer (ROSETTA Lung-02)
Trial Treatment · Phase 2/3 · BioNTech SE
Basildon University Hospital - Basildon And Thurrock University Hospitals Nhs Foundation Trust, Basildon · Royal United Hospital, Bath - Royal United Hospitals Bath NHS Foundation Trust, Bath · Royal Sussex County Hospital - University Hospitals Sussex NHS Foundation Trust, Brighton · Velindre NHS Trust, Velindre Cancer Centre, Cardiff · Royal Marsden Hospital (RMH) - Royal Marsden NHS Foundation Trust, Chelsea · Hull University Teaching Hospitals NHS Trust, Cottingham · Beatson West of Scotland Cancer Centre - Greater Glasgow Health Board, Glasgow · Clatterbridge Cancer Centre, Liverpool · Royal Marsden Hospital (Sutton) - Royal Marsden NHS Foundation Trust, London · University College Hospital, London · The Christie NHS Foundation Trust, Manchester · Norfolk and Norwich University Hospital - Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich · Cancer And Haematology Centre-The Churchill Hospital-Oxford University Hospitals, Oxford · Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust, Preston · Weston Park Hospital - Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield · Southampton General Hospital, Southampton · Musgrove Park Hospital-Taunton & Somerset NHS Foundation Trust, Taunton · New Cross Hospital, Wolverhampton · York Teaching Hospital NHS Foundation Trust - The York Hospital, York
Registry updated 2026-11-02
NCT06745908
Clinical Trial of N-803 Plus Tislelizumab or Prior Failed Immune Checkpoint Inhibitor and Docetaxel Versus Docetaxel Monotherapy in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Acquired Resistance to Immune Checkpoint Inhibitor Therapy
Trial Treatment · Phase 3 · ImmunityBio, Inc.
Belfast Health and Social Care Trust - Belfast City Hospital, Belfast · University Hospital Birmingham NHS Trust, Birmingham · Betsi Cadwaladr University Health Board - Glan Clwyd Hospital, Bodelwyddan · Velindre NHS Trust - Velindre Cancer Centre VCC, Cardiff · NRS South-East Cancer Research Network, Edinburgh · Royal Surrey County Hospital NHS Foundation Trust - St Lukes Cancer Centre, Guildford · Royal London Hospital, London · Southampton General Hospital, Southampton University Hospital National Health Service Trust, Southampton · Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital, Truro · Betsi Cadwaladr University Health Board Wrexham Maelor Hospital, Wrexham
Registry updated 2026-11-02
NCT07185997
Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations
Trial Treatment · Phase 3 · ArriVent BioPharma, Inc.
The Royal Marsden NHS Foundation Trust, London · University College London Hospitals NHS Foundation Trust, London · The Christie NHS Foundation Trust, Manchester
Registry updated 2026-11-02

All Lung cancer trials and the map

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