Lung cancer: open trials in South Africa

• NCT06793215

  A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

  Trial Treatment · Phase 3 · Hoffmann-La Roche

  Wits Donald Gordon Clinical Trial Centre, Parktown · University of Pretoria Oncology Department, Pretoria · Soweto

  Registry updated 2026-11-05

• NCT07144280

  A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

  Trial Treatment · Phase 3 · Pfizer

  The Oncology Centre, Durban · The Medical Oncology Centre of Rosebank, Johannesburg

  Registry updated 2026-11-05

• NCT07365319

  A Safety and Efficacy Study of EIK1001 in Combination With Pembrolizumab and Chemotherapy in Participants With Stage 4 Non-Small Cell Lung Cancer.

  Trial Treatment · Phase 2/3 · Eikon Therapeutics

  Task Eden, George · The Medical Oncology Centre of Rosebank, Saxonwold

  Registry updated 2026-11-03

• NCT04613596

  Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

  Trial Treatment · Phase 2/3 · Mirati Therapeutics Inc.

  Local Institution - 007-4013, Johannesburg · Local Institution - 007-4010, Port Elizabeth · Local Institution - 007-4012, Pretoria

  Registry updated 2026-10-30

• NCT04928846

  A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

  Trial Treatment · Phase 3 · AbbVie

  Wits Clinical Research /ID# 230841, Johannesburg · Sandton Oncology Medical Group PTY Ltd /ID# 230843, Johannesburg · Steve Biko Academic Hospital /ID# 230883, Pretoria

  Registry updated 2026-10-29

• NCT06561386

  A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%

  Trial Treatment · Phase 3 · Bristol-Myers Squibb

  Cape Town Oncology Trials, Cape Town · Wits Clinical Research, Johannesburg · Life Groenkloof, Pretoria · Sandton Oncology Medical Group (Pty) Ltd, Sandton · Wits Clinical Research, Soweto

  Registry updated 2026-10-23

• NCT07671092

  Imaging Study in Metastatic UC, HR+ and HER2- Breast Cancer, TNBC, and NSCLC

  Trial Treatment · Early phase 1 · RayzeBio, Inc.

  Johannesburg · Pretoria

  Registry updated 2026-10-13

All Lung cancer trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

Report an error