Lupus (SLE): open trials in United Kingdom

• NCT05039619

  A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants

  Trial Treatment · Phase 2 · Hoffmann-La Roche

  Royal Hospital for Children, Glasgow · Alder Hey Childrens Hospital, Liverpool · Great Ormond Street Hospital for Children, London

  Registry updated 2026-11-03

• NCT07175285

  A Study in Participants With Active Systemic Lupus Erythematosus With Inadequate Response to Glucocorticoids and ≥2 Immunosuppressants

  Research · Bristol-Myers Squibb

  Royal National Hospital for Rheumatic Diseases-Bath, Bath · King's College Hospital NHS Foundation Trust, London · The Royal Free London NHS Foundation Trust - The Royal Free Hospital, London · Oxford University Hospitals NHS Trust - Churchill Hospital, Oxford · The Royal Wolverhampton NHS Trust - New Cross Hospital, Wolverhampton

  Registry updated 2026-11-02

• NCT07053800

  Obe-cel in Severe, Refractory Systemic Lupus Erythematosus (SLE) With Active Lupus Nephritis (LN)

  Trial Treatment · Phase 2 · Autolus Limited

  Queen Elizabeth Hospital Birmingham, Birmingham · Bristol Haematology and Oncology Centre, Bristol · Addenbrooke's Hospital, Cambridge · Western General Hospital Edinburgh, Edinburgh · Queen Elizabeth University Hospital, Glasgow · Great Ormond Street Hospital, London · University College Hospital, London · Manchester Royal Infirmary, Manchester

  Registry updated 2026-10-30

• NCT07201558

  Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants

  Trial Treatment · Phase 1 · AstraZeneca

  London

  Registry updated 2026-10-28

• NCT06897930

  A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE

  Trial Treatment · Phase 1/2 · AstraZeneca

  Bristol

  Registry updated 2026-09-10

• NCT06308978

  A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease

  Trial Treatment · Phase 1 · Fate Therapeutics

  Cambridge University Hospitals NHS Foundation Trust, Cambridge · University College of London Hospitals NHS Trust (UCLH), London · Manchester University NHS Foundation Trust, Manchester

  Registry updated 2026-05-22

All Lupus (SLE) trials and the map

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