Melanoma: open trials in Canada

33 open trials have a site in Canada. Registry data; only the trial team decides who can take part.

NCT05663775
Prophylactic Mesalamine to Prevent Colitis Following Treatment With Ipilimumab/Nivolumab (Ipi/Nivo)
Trial Treatment · Phase 2 · AHS Cancer Control Alberta
Cross Cancer Institute, Edmonton
Registry updated 2026-11-04
NCT07492680
A Study of Navlimetostat (BMS-986504) Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
Trial Treatment · Phase 2 · Bristol-Myers Squibb
Toronto · Toronto · Vancouver
Registry updated 2026-11-04
NCT03340506
Dabrafenib and/or Trametinib Rollover Study
Trial Treatment · Phase 4 · Novartis Pharmaceuticals
Toronto
Registry updated 2026-11-03
NCT06743126
SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
Trial Treatment · Phase 3 · Immatics US, Inc.
Cross Cancer Institute, Alberta, Edmonton · Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal · University Health Network - Princess Margaret Cancer Centre, Toronto · BC Cancer - Vancouver, Vancouver
Registry updated 2026-10-30
NCT06172478
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Trial Treatment · Phase 2 · Daiichi Sankyo
Cross Cancer Institute, Edmonton · Sunnybrook Research Institute, Toronto · Princess Margaret Cancer Centre, Toronto · BC Cancer - Vancouver, Vancouver
Registry updated 2026-10-26
NCT06246916
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
Trial Treatment · Phase 3 · Regeneron Pharmaceuticals
Arthur J.E. Child Comprehensive Cancer Centre, Calgary · Cross Cancer Institute, Edmonton · London Regional Cancer Centre, London · Jewish General Hospital - Main Address, Montreal · Centre Hospitalier Universitaire de Quebec (CHUQ) - Centre Hospitalier de l'Universite Laval (CHUL), Québec · Princess Margaret Cancer Centre, Toronto · Sunnybrook Health Sciences Centre, Toronto
Registry updated 2026-10-26
NCT07820033
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer: A Randomized Controlled Trial
Trial Treatment · Phase 2 · University Health Network, Toronto
University Health Network, Toronto
Registry updated 2026-10-15
NCT05955924
Nicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients - Pivotal Trial
Trial Treatment · Phase 3 · Women's College Hospital
University Of Calgary, Calgary · University of Alberta, Edmonton · The Ottawa Hospital, Ottawa · Women's College Hospital, Toronto · Toronto General Hospital, Toronto · St. Paul's Hospital, Vancouver · Vancouver General Hospital, Vancouver
Registry updated 2026-10-13
NCT06319196
Clear Me: Interception Trial to Detect and Clear Molecular Residual Disease in Patients With High-risk Melanoma
Trial Treatment · Phase 2 · University Health Network, Toronto
UHN- Princess Margaret Cancer Center, Toronto
Registry updated 2026-10-13
NCT06697301
Safety and Efficacy of EIK1001 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.
Trial Treatment · Phase 2/3 · Eikon Therapeutics
Sunnybrook Research Ins<tute, Toronto
Registry updated 2026-10-06
NCT05196087
Non-Invasive Artificial Intelligence-Based Platform MonIToring Program (NIP IT!)
Research · University Health Network, Toronto
Princess Margaret Cancer Centre, Toronto
Registry updated 2026-09-28
NCT06961006
A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)
Trial Treatment · Phase 2 · Merck Sharp & Dohme LLC
William Osler Health System (Brampton Civic Hospital) ( Site 2023), Brampton · Sunnybrook Research Institute ( Site 2022), Toronto
Registry updated 2026-09-28
NCT03702309
Liquid Biopsy Evaluation and Repository Development at Princess Margaret
Research · University Health Network, Toronto
Princess Margaret Cancer Centre, Toronto
Registry updated 2026-09-25
NCT05727904
Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
Trial Treatment · Phase 3 · Iovance Biotherapeutics, Inc.
Centre Hospitalier de l'Université de Montréal, Montreal · Princess Margaret Cancer Centre, Toronto
Registry updated 2026-09-24
NCT06623461
LND101 for Fecal Microbiota Transplantation in Combination With Immune Checkpoint Blockade in Advanced Melanoma
Trial Treatment · Phase 2 · Canadian Cancer Trials Group
BCCA - Abbotsford, Abbotsford British Columbia · Centre Integre de Sante et de Services Sociaux, Greenfield Park · Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton · London Health Sciences Centre Research Inc., London · CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal · The Research Institute of the McGill University, Montreal · The Jewish General Hospital, Montreal · Stronach Regional Health Centre at Southlake, Newmarket · Ottawa Hospital Research Institute, Ottawa · Hotel-Dieu de Quebec, Québec · BCCA - Surrey, Surrey · University Health Network, Toronto · Odette Cancer Centre, Toronto · Centre Hospitalier Regional de Trois-Rivieres, Trois-Rivières · BCCA - Vancouver, Vancouver
Registry updated 2026-09-15
NCT07804186
Study of Adjuvant Darovasertib and Crizotinib in Participants With Primary Non-metastatic Uveal Melanoma
Trial Treatment · Phase 3 · IDEAYA Biosciences
Universite de Montreal - Centre de Recherche du Centre Hospitalier de l'Universite de Montreal, Montréal · Princess Margaret Cancer Centre, Toronto
Registry updated 2026-09-15
NCT07524114
Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)
Research · University Health Network, Toronto
Princess Margaret Hospital, Toronto
Registry updated 2026-08-21
NCT04895709
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
Trial Treatment · Phase 1/2 · Bristol-Myers Squibb
Cross Cancer Institute, Edmonton · Hamilton Health Sciences-Juravinski Cancer Centre, Hamilton · Centre Hospitalier de luniversite de Montreal, Montreal · Ottawa · Toronto · Vancouver
Registry updated 2026-08-17
NCT05592626
A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
Trial Treatment · Phase 1/2 · Marengo Therapeutics, Inc.
Princess Margaret Cancer Centre, Toronto
Registry updated 2026-08-11
NCT07049276
The Multicentre Selective Lymphadenectomy Trial - 3
Trial Treatment · Melanoma Institute Australia
Sunnybrook Health Sciences Centre, Toronto
Registry updated 2026-06-29
NCT05403177
Marathon of Hope Cancer Centres Network Study for Ontario (MOHCCN-O)
Research · University Health Network, Toronto
Kingston Health Sciences Centre, Kingston · Ottawa Health Research Institute, Ottawa · Princess Margaret Cancer Centre, Toronto
Registry updated 2026-06-10
NCT02821013
Duration of Anti-PD-1 Therapy in Metastatic Melanoma
Trial Treatment · Phase 3 · Canadian Cancer Trials Group
Royal Victoria Regional Health Centre, Barrie · Cross Cancer Institute, Edmonton · Horizon Health Network, Fredericton · Health Sciences North, Greater Sudbury · Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton · Kingston Health Sciences Centre, Kingston · Waterloo Regional Health Network (WRHN), Kitchener · London Health Sciences Centre Research Inc., London · Trillium Health Partners - Credit Valley Hospital, Mississauga · The Research Institute of the McGill University, Montreal · Lakeridge Health Oshawa, Oshawa · Ottawa Hospital Research Institute, Ottawa · Allan Blair Cancer Centre, Regina · Saskatoon Cancer Centre, Saskatoon · BCCA - Surrey, Surrey · University Health Network, Toronto · Odette Cancer Centre, Toronto · BCCA - Vancouver, Vancouver · BCCA - Victoria, Victoria
Registry updated 2026-06-09
NCT03947385
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
Trial Treatment · Phase 1/2 · IDEAYA Biosciences
Princess Margaret Cancer Centre, Toronto
Registry updated 2026-06-08
NCT02906943
Ontario-wide Cancer TArgeted Nucleic Acid Evaluation
Research · University Health Network, Toronto
Juravinski Cancer Centre, Hamilton · Kingston General Hospital, Kingston · London Health Sciences Centre, London · The Ottawa Hospital Cancer Centre, Ottawa · Sunnybrook Health Sciences Centre, Toronto · Mount Sinai Hospital, Toronto · Princess Margaret Hospital, Toronto
Registry updated 2026-06-05
NCT05645510
LIVInG With chrONic Cancer TrEatments (LONGEVITI) Study
Research · University of Alberta
Edith Pituskin, Edmonton
Registry updated 2026-05-11

All Melanoma trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

Report an error