Melanoma: open trials in United Kingdom

34 open trials have a site in United Kingdom. Registry data; only the trial team decides who can take part.

NCT06743126
SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
Trial Treatment · Phase 3 · Immatics US, Inc.
Cambridge University Hospitals NHS Foundation Trust - Addenbrooke's Hospital, Cambridge · Greater Glasgow and Clyde NHS, Beatson West of Scotland Cancer Center, Glasgow · The Royal Marsden NHS Foundation Trust, London · Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital, London · The Christie NHS Foundation Trust, Manchester · Oxford University Hospitals NHS Foundation Trust Churchill Hospital, Oxford · University of Southampton NHS Foundation Trust, Southampton General Hospital, Southampton
Registry updated 2026-10-30
NCT06242470
A Study of MGC026 in Participants With Advanced Solid Tumors
Trial Treatment · Phase 1 · MacroGenics
Oxford University Hospitals NHS Foundation Trust, Oxford · The Royal Marsden NHS Foundation Trust, Sutton
Registry updated 2026-10-28
NCT06172478
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Trial Treatment · Phase 2 · Daiichi Sankyo
Addenbrooke's Hospital, Cambridge · University Hospital Coventry, Coventry · Barts Hospital, London · Royal Free Hospital, London · Nottingham City Hospital Campus, Nottingham
Registry updated 2026-10-26
NCT07883954
Development and Multi-Centre Validation of a Novel Non-Invasive Melanoma Molecular Diagnostic Test
Research · Mitra Bio
Royal Free Hospital, London · Whittington Hospital, London
Registry updated 2026-10-21
NCT07070232
A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
Trial Treatment · Phase 1/2 · BioNTech SE
Queen Elizabeth Hospital, Birmingham · Velindre Cancer Centre, Cardiff · Beatson West of Scotland Cancer Centre, Glasgow · The Clatterbridge Cancer Centre, Liverpool · Royal Free Hospital, London · Royal Marsden Hospital - London, London · University College London Hospitals, London · Imperial College London, London · The Christie Hospital, Manchester · Northern Centre for Cancer Care, Newcastle upon Tyne · Southampton General Hospital, Southampton · Royal Marsden Hospital, Sutton
Registry updated 2026-10-09
NCT06697301
Safety and Efficacy of EIK1001 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.
Trial Treatment · Phase 2/3 · Eikon Therapeutics
Belfast City Hospital, Belfast Health and Social Care Trust, Belfast · Sarah Cannon Research Institute London, London · Guy's and St Thomas' NHS Foundation Trust, London · University Hospital Southampton, Southampton
Registry updated 2026-10-06
NCT05727904
Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
Trial Treatment · Phase 3 · Iovance Biotherapeutics, Inc.
Queen Elizabeth Hospital Birmingham, Birmingham · Royal Marsden Hospital, Chelsea · Beaston West of Scotland Canter Centre, Glasgow · Guy's Hospital, London · Sarah Cannon Research Institute UK, London · Freeman Hospital, Newcastle upon Tyne
Registry updated 2026-09-24
NCT04752826
BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)
Trial Treatment · Phase 1/2 · BioInvent International AB
University Hospital Birmingham, Birmingham · University Hospitals of Leicester NHS Trust, Leicester · Sarah Cannon Research Institute UK, London · Guy's and Saint Thomas' NHS Foundation Trust, London · The Royal Marsden Hospital NHS Foundation Trust, London · The Christie NHS Foundation Trust, Manchester · Southampton General Hospital, Southampton
Registry updated 2026-09-18
NCT07815574
iSCIB1+ in Combination With Ipilimumab and Nivolumab as First-Line Treatment for Advanced Unresectable Melanoma
Trial Treatment · Phase 3 · Scancell Ltd
Mount Vernon Cancer Centre, London
Registry updated 2026-09-11
NCT07718243
Investigating the Combination of Bexmarilimab and Nivolumab in Solid Tumours, Melanoma and NSCLC
Trial Treatment · Phase 1/2 · Institute of Cancer Research, United Kingdom
The Christie NHS Foundation Trust, Manchester · The Royal Marsden NHS Foundation Trust - Drug Development Unit, Sutton
Registry updated 2026-09-08
NCT07440290
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
Trial Treatment · Phase 2/3 · Cancer Research UK
Belfast City Hospital, Belfast · Birmingham Children's Hospital, Birmingham · University Hospital Birmingham, Birmingham · Bristol Royal Hospital for Children, Bristol · Bristol Haematology and Oncology Centre, Bristol · Addenbrooke's Hospital, Cambridge · Cardiff Children's Hospital, Cardiff · Velindre Cancer Centre, Cardiff · Western General Hospital, Edinburgh · The Beatson Hospital, Glasgow · Royal Hospital for Children Glasgow, Glasgow · Leicester Royal Infirmary, Leicester · Alder Hey Hospital, Liverpool · Great Ormond Street Hospital, London · Guy's Hopsital, London · University College London Hospital, London · Royal Manchester Children's Hospital, Manchester · The Christie Hospital, Manchester · Clatterbridge Cancer Centre, Metropolitan Borough of Wirral · Great North Children's Hospital, Newcastle · Freeman Hospital, Newcastle · Churchill Hospital, Oxford · John Radcliffe Hospital, Oxford · Weston Park Hospital, Sheffield · Sheffield's Children's Hospital, Sheffield · Southampton General Hospital, Southampton · The Royal Marsden Hospital, Sutton
Registry updated 2026-08-17
NCT06264180
VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]
Trial Treatment · Phase 3 · Replimune, Inc.
Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool · The Royal Marsden NHS Foundation Trust, London · Guy's & St Thomas' NHS Foundation Trust, London · Royal Free London NHS Foundation Trust Royal Free Hospital, London · The Christie NHS Foundation Trust, Manchester
Registry updated 2026-07-15
NCT02332668
A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)
Trial Treatment · Phase 1/2 · Merck Sharp & Dohme LLC
Merck Sharp & Dohme Ltd., London
Registry updated 2026-07-06
NCT06246149
Adjuvant Tebentafusp in High Risk Ocular Melanoma
Trial Treatment · Phase 3 · European Organisation for Research and Treatment of Cancer - EORTC
The Clatterbridge cancer Center NHS foundation Trust - Clatterbridge Cancer Center - Liverpool, Liverpool · East and North Hertfordshire NHS Trust - Mount Vernon Hospital, Northwood
Registry updated 2026-06-30
NCT07049276
The Multicentre Selective Lymphadenectomy Trial - 3
Trial Treatment · Melanoma Institute Australia
The Royal Marsden, London
Registry updated 2026-06-29
NCT07015190
Neoadjuvant Darovasertib in Primary Uveal Melanoma
Trial Treatment · Phase 3 · IDEAYA Biosciences
University College Hospital, London · Clatterbridge Cancer Centre - Liverpool - NWCRN - PPDS, Metropolitan Borough of Wirral · Weston Park Cancer Centre - PPDS, Sheffield
Registry updated 2026-05-06
NCT05522660
Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer
Trial Treatment · Phase 3 · ETOP IBCSG Partners Foundation
Royal Marsden (Sutton), London · Christie NHS Manchester, Manchester
Registry updated 2026-04-27
NCT06581406
A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
Trial Treatment · Phase 2/3 · Replimune, Inc.
The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool · The Royal Marsden NHS Foundation Trust, London
Registry updated 2026-04-02
NCT05549297
Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)
Trial Treatment · Phase 3 · Immunocore Ltd
Queen Elizabeth Hospital, Birmingham · Addenbrooke's Hospital, Cambridge · Leeds General Infirmary, Leeds · Royal Marsden Hospital (Chelsea), London · Sarah Cannon Research Institute UK, London · Guys St Thomas NHS Foundation Trust, London · The Christie NHS Foundation Trust, Manchester · Mount Vernon Cancer Center, Middlesex · Royal Marsden Hospital (Sutton), Sutton
Registry updated 2026-02-25
NCT06112314
IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)
Trial Treatment · Phase 3 · Immunocore Ltd
Queen Elizabeth Hospital Birmingham, Birmingham · Cambridge University Hospitals NHS Foundation Trust - Addenbrooke's Hospital (AH) - Oncology Centre, Cambridge · Beatson West of Scotland Cancer Centre, Glasgow · The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool · Sarah Cannon Research Institute (SCRI) - London (SCRI-UK), London · The Christie NHS Foundation Trust, Manchester · University of Oxford, Oxford · Royal Marsden Hospital - Sutton, Surrey Quays
Registry updated 2026-02-25
NCT03829254
A Safety, Pharmacokinetic and Clinical Activity Study of NUC-7738 in Patients With Advanced Solid Tumours and Lymphoma
Trial Treatment · Phase 1/2 · NuCana plc
Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital, Cambridge · Edinburgh Cancer Centre, Western General Hospital, Edinburgh · The Beatson West of Scotland Cancer Centre, Glasgow · The Royal Marsden NHS Foundation Trust, London · University College London Hospital, London · The Christie NHS Foundation Trust, Manchester · Freeman Hospital, Newcastle · Oxford University Hospitals NHS Foundation Trust, Oxford · Lancashire Teaching Hospitals NHS Foundation Trust, Royal Preston Hospital, Preston
Registry updated 2026-01-12
NCT07293598
Investigation of the ROle of faT and inflAmmaTory Cells in mElanoma
Research · The Christie NHS Foundation Trust
The Christie NHS Foundation Trust, Manchester
Registry updated 2025-12-19
NCT05768178
DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.
Trial Treatment · Phase 2/3 · Cancer Research UK
Belfast City Hospital, Belfast · University Hospital Birmingham, Birmingham · Bristol Haematology and Oncology Centre, Bristol · Addenbrooke's Hospital, Cambridge · Velindre Cancer Centre, Cardiff · Western General Hospital, Edinburgh · The Beatson Hospital, Glasgow · Leicester Royal Infirmary, Leicester · Guy's Hospital, London · University College London Hospital, London · The Christie Hospital, Manchester · Clatterbridge Cancer Centre, Metropolitan Borough of Wirral · Freeman Hospital, Newcastle · Churchill Hospital, Oxford · Weston Park Hospital, Sheffield · Southampton General Hospital, Southampton
Registry updated 2025-11-24
NCT05770102
DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition
Trial Treatment · Phase 2/3 · Cancer Research UK
Belfast City Hospital, Belfast · Birmingham Children's Hospital, Birmingham · University Hospital Birmingham, Birmingham · Bristol Royal Hospital for Children, Bristol · Bristol Haematology and Oncology Centre, Bristol · Addenbrooke's Hospital, Cambridge · Cardiff Children's Hospital, Cardiff · Velindre Cancer Centre, Cardiff · Western General Hospital, Edinburgh · The Beatson Hospital, Glasgow · Royal Hospital for Children Glasgow, Glasgow · Leicester Royal Infirmary, Leicester · Alder Hey Hospital, Liverpool · University College London Hospital, London · Guy's Hospital, London · Great Ormond Street Hospital, London · Royal Manchester Children's Hospital, Manchester · The Christie Hospital, Manchester · Clatterbridge Cancer Centre, Metropolitan Borough of Wirral · Great North Children's Hospital, Newcastle · Freeman Hospital, Newcastle · Churchill Hospital, Oxford · John Radcliffe Hospital, Oxford · Weston Park Hospital, Sheffield · Sheffield's Children's Hospital, Sheffield · Southampton General Hospital, Southampton · The Royal Marsden Hospital, Sutton
Registry updated 2025-11-24
NCT05770544
DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.
Trial Treatment · Phase 2/3 · Cancer Research UK
Belfast City Hospital, Belfast · University Hospital Birmingham, Birmingham · Birmingham Children's Hospital, Birmingham · Bristol Royal Hospital for Children, Bristol · Bristol Haematology and Oncology Centre, Bristol · Addenbrooke's Hospital, Cambridge · Velindre Cancer Centre, Cardiff · Cardiff Children's Hospital, Cardiff · Western General Hospital, Edinburgh · The Beatson Hospital, Glasgow · Royal Hospital for Children Glasgow, Glasgow · Leicester Royal Infirmary, Leicester · Alder Hey Hospital, Liverpool · Guy's Hospital, London · University College London Hospital, London · Great Ormond Street Hospital, London · Royal Manchester Children's Hospital, Manchester · The Christie Hospital, Manchester · Clatterbridge Cancer Centre, Metropolitan Borough of Wirral · Great North Children's Hospital, Newcastle · Freeman Hospital, Newcastle · Churchill Hospital, Oxford · John Radcliffe Hospital, Oxford · Weston Park Hospital, Sheffield · Sheffield's Children's Hospital, Sheffield · Southampton General Hospital, Southampton · The Royal Marsden Hospital, Sutton
Registry updated 2025-11-24

All Melanoma trials and the map

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