Myasthenia gravis: open trials in Japan

• NCT07463521

  A Study to Evaluate the Efficacy and Safety of Rozanolixizumab in Adult Participants With Ocular Myasthenia Gravis

  Trial Treatment · Phase 3 · UCB Biopharma SRL

  Mg0038 31802, Kobe · Mg0038 31804, Minatoku · Mg0038 31805, Sendai

  Registry updated 2026-11-06

• NCT07465289

  A Study to Evaluate The Long-Term Safety And Efficacy of Rozanolixizumab in Adult Participants With Ocular Myasthenia Gravis

  Trial Treatment · Phase 3 · UCB Biopharma SRL

  Mg0039 31802, Kobe · Mg0039 31804, Minatoku · Mg0039 31805, Sendai

  Registry updated 2026-11-06

• NCT04951622

  A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

  Trial Treatment · Phase 3 · Janssen Research & Development, LLC

  Chiba University Hospital, Chiba · General Hanamaki Hospital, Hanamaki · Hiroshima University Hospital, Hiroshima · St. Marianna University Hospital, Kawasaki-shi · Kagawa University Hospital, Kita-gun · Kumamoto University Hospital, Kumamoto · National Hospital Organization Nagoya Medical Center, Nagoya · Niigata City General Hospital, Niigata · Hyogo College of Medicine Hospital, Nishinomiya-shi · Hokkaido Medical Center, Sapporo · Sapporo Medical University Hospital, Sapporo · National Hospital Organization Sendai Medical Center, Sendai · Iwate Medical University Hospital, Shiwa-gun · Teikyo University Hospital, tabashi City · Tokushima University Hospital, Tokushima · Tokyo Medical University Hospital, Tokyo

  Registry updated 2026-11-05

• NCT05265273

  A Study of Nipocalimab in Children Aged 2 to Less Than 18 Years With Generalized Myasthenia Gravis

  Trial Treatment · Phase 2/3 · Janssen Research & Development, LLC

  Nagano Children's Hospital, Azumino-shi · Chiba University Hospital, Chiba · University of Miyazaki Hospital, Miyazaki · Hyogo College of Medicine Hospital, Nishinomiya-shi · Saitama Prefecture Children's Medical Center, Saitama Shi · Tokyo Women's Medical University Hospital, Shinjuku-ku

  Registry updated 2026-11-04

• NCT07673627

  ADAPT Forward 2 - ISA2 - a Study to Evaluate the Safety, Tolerability and Efficacy of Empasiprubart IV Monotherapy in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis

  Trial Treatment · Phase 2 · argenx

  General Hanamaki Hospital, Hanamaki · National Hospital Organization Sendai Medical Center, Sendai

  Registry updated 2026-11-04

• NCT07294170

  ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis

  Research · argenx

  General Hanamaki Hospital - Kajomachi, Hanamaki · St. Marianna University Hospital, Kawasaki-shi · IUHW Narita Hospital, Narita · National Hospital Organization Sendai Medical Center, Sendai · University of Tsukuba Hospital, Tsukuba

  Registry updated 2026-10-26

• NCT06463587

  Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)

  Trial Treatment · Phase 3 · Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

  Chiba University Hospital - Dept of Neurology, Chiba · Fukuoka University Hospital - Dept of Neurology/Health Care, Fukuoka · Hakodate Municipal Hospital - Dept of Neurology, Hakodate-shi · General Hanamaki Hospital - Dept of Neurology, Hanamaki-shi · Saitama Medical University Hospital - Dept of Neurology/Stroke Care Unit, Iruma-gun · Kagawa University Hospital - Dept of Neurology, Kita-gun · Southern Tohoku Medical Clinic - Dept of Neurology, Koriyama-shi · Toho University Ohashi Medical Center - Dept of Neurology, Meguro-ku · Nagasaki University Hospital - Dept of Neurology, Nagasaki · IUHW Narita Hospital - Dept of Neurology, Narita-shi · Tokyo Medical University Hospital - Dept of Neurology, Shinjuku-ku · Osaka University Hospital - Dept of Neurology/Stroke Care Unit, Suita-shi

  Registry updated 2026-10-21

• NCT07284420

  ADAPT Forward 1 - ISA1 - a Study to Evaluate Empasiprubart IV as add-on Therapy to Efgartigimod IV in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis With a Partial Clinical Response to Efgartigimod

  Trial Treatment · Phase 2 · argenx

  General Hanamaki Hospital - Kajomachi, Hanamaki · St. Marianna University Hospital, Kawasaki-shi · IUHW Narita Hospital, Narita · National Hospital Organization Sendai Medical Center, Sendai · University of Tsukuba Hospital, Tsukuba

  Registry updated 2026-09-24

• NCT07221838

  A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With Ravulizumab

  Trial Treatment · Phase 4 · Alexion Pharmaceuticals, Inc.

  Ibaraki · Kitakyushu-shi · Kumamoto

  Registry updated 2026-04-09

• NCT06607627

  PK, PD, Safety, and Efficacy Study of Gefurulimab in Pediatric Patients With AChR+ Generalized Myasthenia Gravis

  Trial Treatment · Phase 3 · Alexion Pharmaceuticals, Inc.

  Saitama-shi

  Registry updated 2026-04-01

All Myasthenia gravis trials and the map

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