Myeloproliferative neoplasms: open trials in Canada

21 open trials have a site in Canada. Registry data; only the trial team decides who can take part.

NCT05554406
Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)
Trial Treatment · Phase 2 · National Cancer Institute (NCI)
Arthur J.E. Child Comprehensive Cancer Centre, Calgary · University of Alberta Hospital, Edmonton · CSSS Champlain-Charles Le Moyne, Greenfield Park · QEII Health Sciences Centre/Nova Scotia Health Authority, Halifax · CIUSSSEMTL-Hopital Maisonneuve-Rosemont, Montreal · Jewish General Hospital, Montreal · Ottawa Hospital and Cancer Center-General Campus, Ottawa · University Health Network, Princess Margaret Hospital, Toronto · CancerCare Manitoba, Winnipeg
Registry updated 2026-11-06
NCT07357727
A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF)
Trial Treatment · Phase 3 · Novartis Pharmaceuticals
Jewish General Hospital, Montreal
Registry updated 2026-11-06
NCT07623161
A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib
Trial Treatment · Phase 3 · Takeda
Clinical Research Unit Arthur J.E. Child Comprehensive Cancer Centre, Calgary · Juravinski Cancer Centre, Hamilton · CISSSCA, Lévis · London Health Sciences Centre, London · McGill University Health Center, Montreal · Jewish General Hospital, Montreal · Princess Margaret Cancer Centre, Toronto
Registry updated 2026-11-06
NCT07623200
A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia
Trial Treatment · Phase 3 · Incyte Corporation
Juravinski Cancer Centre-Hamilton Health Sciences (Hhs), Hamilton · Queens University, Kingston General Hospital (Kgh), Kingston Health Sciences Centre (Khsc), Kingston · Sir Mortimer B Davis - Jewish General Hospital, Montreal · McGill University Health Centre - Glen Site, Centre For Innovative Medicine, Montreal · Hotel-Dieu de Levis, Québec · University Health Network UHN Princess Margaret Cancer Centre, Toronto · St. Paul'S Hospital (Sph), Providence Health Care, University of British Columbia, Vancouver
Registry updated 2026-11-05
NCT07722611
A Clinical Trial of Bomedemstat in Participants With Polycythemia Vera (MK-3543-025).
Trial Treatment · Phase 2/3 · Merck Sharp & Dohme LLC
Princess Margaret Cancer Centre (Site 4002), Toronto
Registry updated 2026-11-05
NCT06150157
A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms
Trial Treatment · Phase 1 · Janssen Research & Development, LLC
Arthur J.E. Child Comprehensive Cancer Centre, Calgary · Jewish General Hospital, Montreal · Princess Margaret Cancer Centre - University Health Network, Toronto
Registry updated 2026-11-04
NCT06517875
Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis
Trial Treatment · Phase 2 · GlaxoSmithKline
Montreal · Toronto · Vancouver
Registry updated 2026-11-04
NCT05564390
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)
Trial Treatment · Phase 2 · National Cancer Institute (NCI)
Arthur J.E. Child Comprehensive Cancer Centre, Calgary · University of Alberta Hospital, Edmonton · CSSS Champlain-Charles Le Moyne, Greenfield Park · QEII Health Sciences Centre/Nova Scotia Health Authority, Halifax · Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton · CIUSSSEMTL-Hopital Maisonneuve-Rosemont, Montreal · Jewish General Hospital, Montreal · Ottawa Hospital and Cancer Center-General Campus, Ottawa · Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto · University Health Network, Princess Margaret Hospital, Toronto · CancerCare Manitoba, Winnipeg
Registry updated 2026-11-02
NCT07441694
Study of INCA036978 in Participants With Myeloproliferative Neoplasms
Trial Treatment · Phase 1 · Incyte Corporation
McGill University - Jewish General Hospital, Montreal · Princess Margaret Cancer Centre, Toronto
Registry updated 2026-10-30
NCT04176198
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Trial Treatment · Phase 1/2 · Sumitomo Pharma America, Inc.
University Of Calgary, Calgary · Juravinski Cancer Center, Hamilton · Jewish General Hospital, Montreal · Princess Margaret Cancer Center, Toronto · St. Paul's Hospital Hematology/Oncology Research, Vancouver · University of British Columbia, Vancouver
Registry updated 2026-10-02
NCT04996875
(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis
Trial Treatment · Phase 2 · Cogent Biosciences, Inc.
University of Alberta Hospital, Edmonton · St. Michael's Hospital, Unity Health Toronto, Toronto
Registry updated 2026-09-15
NCT02402244
Project: Every Child for Younger Patients With Cancer
Research · Children's Oncology Group
Alberta Children's Hospital, Calgary · University of Alberta Hospital, Edmonton · IWK Health Centre, Halifax · McMaster Children's Hospital at Hamilton Health Sciences, Hamilton · Kingston Health Sciences Centre, Kingston · Children's Hospital, London · The Montreal Children's Hospital of the MUHC, Montreal · Centre Hospitalier Universitaire Sainte-Justine, Montreal · Children'S Hospital Of Eastern Ontario, Ottawa · CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec · Jim Pattison Children's Hospital, Saskatoon · Saskatoon Cancer Centre, Saskatoon · Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke · Janeway Child Health Centre, St. John's · Hospital for Sick Children, Toronto · British Columbia Children's Hospital, Vancouver · CancerCare Manitoba, Winnipeg
Registry updated 2026-08-25
NCT04877522
Asciminib Roll-over Study
Trial Treatment · Phase 4 · Novartis Pharmaceuticals
Montreal
Registry updated 2026-07-06
NCT05074355
Study of Venetoclax and Azacitidine in Advanced BCR-ABL Negative Myeloproliferative Neoplasms
Trial Treatment · Phase 2 · University Health Network, Toronto
Princess Margaret Cancer Centre, Toronto
Registry updated 2026-07-06
NCT04064060
A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials
Trial Treatment · Phase 3 · Celgene
Toronto · Toronto · Toronto
Registry updated 2026-07-01
NCT07528417
Evaluation of Antibiotic Prophylaxis in Myelodysplastic Syndromes and Acute Myeloid Leukemia (MYELO-CAN:ABX)
Trial Treatment · Phase 2 · University of Manitoba
CancerCare Manitoba, Winnipeg
Registry updated 2026-06-29
NCT06599762
Evaluation of Tranexamic Acid in Myelodysplastic Syndromes and Acute Myeloid Leukemia
Trial Treatment · Phase 2 · University of Manitoba
CancerCare Manitoba, Winnipeg
Registry updated 2026-04-22
NCT05980806
A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia
Trial Treatment · Phase 2 · Karyopharm Therapeutics Inc
Research Institute of the McGill University Health Centre, Montreal
Registry updated 2026-02-12
NCT06270771
OURA Ring Wearable Testing in MDS Patients: a Feasibility and Discovery Pilot Study
Research · Sunnybrook Health Sciences Centre
Sunnybrook Health Sciences Research Centre, Toronto
Registry updated 2025-07-08
NCT06785870
EVAluation of Erythrocytosis PRospEctive Cohort STudy
Research · Cyrus Hsia
Victoria Hospital, London Health Sciences Centre, London
Registry updated 2025-01-21
NCT02760238
Myeloproliferative Neoplasms (MPNs) Patient Registry
Research · University Health Network, Toronto
Princess Margaret Cancer Centre, Toronto
Registry updated 2024-08-27

All Myeloproliferative neoplasms trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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