Sarcoma: open trials in Spain

40 open trials have a site in Spain. Registry data; only the trial team decides who can take part.

NCT07328425
Clinical Study in Adult and Young Adult Patients With Advanced Desmoplastic Small Round Cell Tumor (DSRCT) ISG-TULIPS
Trial Treatment · Phase 2 · Italian Sarcoma Group
Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca, Barcelona · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Clínico San Carlos, Madrid · University Hospital Virgen Del Rocio S.L., Sevilla · Hospital Universitario Miguel Servet, Zaragoza · HOSPITAL CLINICO UNIVERSITARIO VIRGEN DE LA ARRIXACA
Registry updated 2026-11-03
NCT06395103
Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
Trial Treatment · Phase 1/2 · Merck Sharp & Dohme LLC
Hospital Universitari Vall d'Hebron, Barcelona · Sant Joan De Deu Barcelona Hospital, Esplugues De Llobregat · Hospital Infantil Universitario Nino Jesus, Madrid · Hospital Universitario Y Politecnico La Fe, Valencia
Registry updated 2026-10-30
2024-520318-23-00
Clinical trial of selinexor plus gemcitabine in selected advanced soft-tissue sarcomas
Trial Treatment · Phase 1/2 · Asociacion Europea Y Latinoamericana SELNET Para La Investigacion En Sarcomas
Hospital Universitari Vall d'Hebron, Barcelona · Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital Universitario Donostia, Donostia · Hospital Universitario La Paz, Madrid · Hospital Clínico San Carlos, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · University Clinical Hospital Virgen De La Arrixaca, Murcia · Hospital Universitario de Canarias, San Cristóbal de La Laguna · Hospital Clinico Universitario de Valencia, Valencia · Hospital Universitario Miguel Servet, Zaragoza
Registry updated 2026-10-28
NCT06441331
Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors
Trial Treatment · Phase 1 · ITM Solucin GmbH
Hospital Universitari Vall d'Hebron, Barcelona · Hospital General Universitario Gregorio Marañón, Madrid
Registry updated 2026-10-27
NCT06345729
A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Hospital Universitari Vall d'Hebron, Barcelona · Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria · Hospital Universitario Severo Ochoa, Leganés · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Universitario de la Princesa, Madrid · Hospital Universitario Virgen de la Victoria, Málaga · Hospital Universitario Regional de Málaga, Málaga · Hospital Universitario Virgen De La Macarena, Sevilla · Consorci Hospitalari de Vic, Vic
Registry updated 2026-10-26
NCT07871864
Fight Osteosarcoma Through European Research Evolving Study Platform From Diagnosis to Relapse
Trial Treatment · Phase 3 · Gustave Roussy, Cancer Campus, Grand Paris
Hospital Universitario Cruces, Barakaldo · Vall d'Hebron Institute of Oncology (VHIO), Barcelona · Hospital Universitario del Niño Jesús, Madrid · Hospital General Universitario Gregorio Marañón, Pediatric and adolescent onco-haematology unit, Madrid · Hospital Virgen de la Arrixaca, Murcia · Hospital Universitario de Canarias, Santa Cruz de Tenerife · Hospital Universitario Virgen del Rocio, Seville · Hospital Universitari i Politécnic La Fe, Valencia · Hospital Universitario Miguel Servet, Zaragoza
Registry updated 2026-10-26
NCT07541170
A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)
Trial Treatment · Phase 3 · Hoffmann-La Roche
Complexo Hospitalario Universitario A Coruña, A Coruña · Hospital Germans Trias i Pujol, Badalona · Hospital Universitari Vall d'Hebron, Barcelona · Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital Universitario Basurto, Bilbao · Hospital Universitario Clínico San Cecilio, Granada · Hospital Universitari Arnau De Vilanova De La Gerencia Territorial De Lleida, Lleida · Hospital Universitario La Paz, Madrid · Hospital Universitario 12 de Octubre, Madrid · Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda · Hospital Universitario Virgen de la Victoria, Málaga · Hospital Son Llatzer, Palma · Salut Sant Joan de Reus, Reus · Parc Tauli Hospital Universitari, Sabadell · Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife · Hospital Universitario San Juan de Alicante, Sant Joan d'Alacant · University Hospital Virgen Del Rocio S.L., Sevilla · Hospital Universitario Y Politecnico La Fe, Valencia · Hospital Universitario Miguel Servet, Zaragoza
Registry updated 2026-10-13
NCT04031677
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
Trial Treatment · Phase 3 · European Organisation for Research and Treatment of Cancer - EORTC
Hospital de la Santa Creu i Sant Pau, Barcelona · Institut Catala d'Oncologia - ICO Badalona - Hospital Germans Trias i Pujol, Barcelona · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Universitario San Carlos, Madrid
Registry updated 2026-10-07
NCT06760819
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Trial Treatment · Phase 2 · Bayer
Instituto Oncologico Dr. Rosell S.L. | Oncologia, Barcelona · Hospital Universitari Vall D Hebron | Oncologia Medica, Barcelona · Institut Catala D'oncologia | Hospitalet | Oncologia, L'Hospitalet de Llobregat · Clinica Universidad De Navarra | Madrid | Oncologia, Madrid · Hospital Universitario Fundacion Jimenez Diaz | Oncologia Medica, Madrid
Registry updated 2026-10-02
NCT06884618
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)
Trial Treatment · Phase 1 · Hoffmann-La Roche
Instituto de Investigacion Oncologica Vall dHebron (VHIO) - EPON, Barcelona · Hospital Universitario 12 de Octubre, Madrid · Clínica Universidad de navarra, Pamplona
Registry updated 2026-09-28
NCT04094610
A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations
Trial Treatment · Phase 1/2 · Turning Point Therapeutics, Inc.
Hospital Universitari Vall d'Hebron, Barcelona · Sant Joan De Deu Barcelona Hospital, Esplugues De Llobregat · Hospital Universitario HM Sanchinarro, Madrid · Clinica Universidad de Navarra, Madrid · Hospital Infantil Universitario Nino Jesus, Madrid · Clínica Universidad de navarra, Pamplona · University Hospital Virgen Del Rocio S.L., Sevilla · Hospital Universitario Y Politecnico La Fe, Valencia
Registry updated 2026-09-25
NCT07629960
A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations
Trial Treatment · Phase 1/2 · Blueprint Medicines Corporation
Hospital Universitario Vall d'Hebron, Barcelona · Mi Cancer Center Barcelona (Pratia Sirius Barcelona), Barcelona · Hospital Universitario 12 de Octubre, Madrid · Hospital General Universitrio Gregorio Maranon, Madrid · Clinica Universidad de Navarra (CUN), Pamplona · NEXT Oncology - Madrid, Pozuelo de Alarcón
Registry updated 2026-09-21
2026-525703-27-00
Multicentre, randomized, open label study comparing the concomitant administration of trabectedin and low-dose radiotherapy versus trabectedin alone in patients with advanced sarcoma
Trial Treatment · Phase 4 · Instituto De Investigacion Sanitaria Fundacion Jimenez Diaz
Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital Universitari Vall d'Hebron, Barcelona · Hospital Universitario Basurto, Bilbao · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Universitario 12 de Octubre, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Clínico San Carlos, Madrid · Hospital Universitario Central De Asturias, Oviedo · Hospital Universitario de Canarias, San Cristóbal de La Laguna · University Hospital Virgen Del Rocio S.L., Sevilla · Hospital Clinico Universitario de Valencia, Valencia · Hospital Universitario Y Politecnico La Fe, Valencia · Hospital Universitario Miguel Servet, Zaragoza
Registry updated 2026-09-18
2025-521702-18-00
A phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of [177Lu]Lu-DFC413 and safety and imaging properties of [68Ga]Ga-NNS309 in patients with solid tumors
Trial Treatment · Phase 1 · Novartis Pharma AG
Hospital Universitari Vall d'Hebron, Barcelona · Institut Catala D'oncologia, L'Hospitalet de Llobregat
Registry updated 2026-09-15
NCT03715933
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
Trial Treatment · Phase 1 · Inhibrx Biosciences, Inc
Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital Universitari Vall d'Hebron, Barcelona · Hospital Clínico San Carlos, Madrid
Registry updated 2026-09-08
NCT05732831
Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors
Trial Treatment · Phase 1/2 · Tango Therapeutics, Inc.
ICO l'Hospitalet - Hospital Duran i Reynals, Barcelona · Vall d'Hebron Barcelona Hospital, Barcelona · Hospital HM Nou Delfos, Barcelona · Hospital de Sanchinarro, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Universitario Virgen de la Victoria, Málaga · Hospital Universitario Virgen del Rocio, Seville
Registry updated 2026-09-08
2024-518199-30-00
Phase I-II prospective trial, multicenter, open label, exploring the combination of Trabectedin plus RAdiotherapy in Soft Tissue Sarcoma patients
Trial Treatment · Phase 1/2 · Asoc Grupo Espanol De Investigacion En Sarcomas
Hospital Universitari Vall d'Hebron, Barcelona · Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Universitario La Paz, Madrid · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Universitario Puerta de Hierro de Majadahonda, Madrid · University Hospital Son Espases, Palma · Hospital Universitario de Canarias, San Cristóbal de La Laguna · University Hospital Virgen Del Rocio S.L., Sevilla · Hospital Universitario Miguel Servet, Zaragoza
Registry updated 2026-09-04
NCT07252739
KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)
Trial Treatment · Phase 2 · Merck Sharp & Dohme LLC
Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón · Hospital Universitario Virgen De La Macarena, Sevilla
Registry updated 2026-09-02
NCT07460986
A Phase Ib/II Study to Evaluate Safety and Efficacy of Bexmarilimab in Combination With Doxorubicin in Metastatic Soft-tissue Sarcoma.
Trial Treatment · Phase 1/2 · MedSIR
Institut Catala d'Oncologia, Badalona · Hospital Universitari Vall d'Hebron, Barcelona · Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Clínico San Carlos, Madrid · Hospital Universitario 12 de Octubre, Madrid · Hospital Universitario La Paz, Madrid · Hospital Universitario Virgen de la Victoria, Málaga · Hospital Universitario de Canarias, San Cristóbal de La Laguna · University Hospital Virgen Del Rocio S.L., Sevilla · Consorcio Hospital General Universitario de Valencia, Valencia · Hospital Universitario Miguel Servet, Zaragoza
Registry updated 2026-08-31
2024-513033-21-00
Long-Term Follow-Up (LTFU) of Participants Treated with Adoptive Cell Therapies
Trial Treatment · Phase 1 · USWM Ct LLC
University Hospital Virgen Del Rocio S.L., Sevilla
Registry updated 2026-08-14
NCT06263231
A Study to Investigate Efficacy & Safety of Intratumoral INT230-6 Compared to US Standard of Care in Adults With Soft Tissue Sarcomas (INVINCIBLE-3)
Trial Treatment · Phase 3 · Intensity Therapeutics, Inc.
Hospital Universitari Vall d'Hebron, Barcelona · Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital Universitario Virgen de las Nieves, Granada · Institut Catala D'oncologia, L'Hospitalet de Llobregat · Clinica Universidad de Navarra, Madrid · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Universitario HM Sanchinarro, Madrid · Hospital Clínico San Carlos, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · Clínica Universidad de navarra, Pamplona · University Hospital Virgen Del Rocio S.L., Sevilla · Hospital Universitario Y Politecnico La Fe, Valencia
Registry updated 2026-08-11
2024-513514-35-00
Trial to evaluate CAR-T NKG2D CAR cell infusions in patients with advanced sarcoma
Trial Treatment · Phase 1 · Hospital Universitario La Paz
Hospital Universitario La Paz, Madrid
Registry updated 2026-07-24
NCT05131386
Clinical trial of trabectedin, irinotecann and low-dose radiation therapy in advanced/metastatic sarcomas.
Trial Treatment · Phase 2 · Asoc Grupo Espanol De Investigacion En Sarcomas
Vall D'hebron Institut De Recerca, Barcelona · Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital Universitario De Canarias, La Laguna · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Universitario La Paz, Madrid · Hospital Clínico San Carlos, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Universitario Y Politecnico La Fe, Valencia
Registry updated 2026-07-08
NCT06607692
Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).
Trial Treatment · Phase 1/2 · Fundación de investigación HM
HM Monteprincipe, Boadilla del Monte
Registry updated 2026-06-04
NCT07223047
A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies
Trial Treatment · Phase 1/2 · Bristol-Myers Squibb
Local Institution - 0006, Badalona · Local Institution - 0008, Hortaleza
Registry updated 2026-05-28

All Sarcoma trials and the map

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