Sarcoma: open trials in United Kingdom

32 open trials have a site in United Kingdom. Registry data; only the trial team decides who can take part.

NCT06395103
Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
Trial Treatment · Phase 1/2 · Merck Sharp & Dohme LLC
Birmingham Children's Hospital-Oncology/Haematology ( Site 1349), Birmingham · University Hospital of Wales ( Site 1346), Cardiff · University College London Hospital ( Site 1350), London · Royal Victoria Infirmary-Great North Children's Hospital ( Site 1348), Newcastle upon Tyne · Royal Marsden Hospital (Sutton)-Drug Development Unit ( Site 1347), Sutton
Registry updated 2026-10-30
NCT04557449
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
Trial Treatment · Phase 1/2 · Pfizer
Cancer Research UK Edinburgh Centre, Edinburgh · St. Bartholomew's Hospital, London · Sarah Cannon Research Institute UK, London · The Christie Hospital NHS Foundation Trust, Manchester
Registry updated 2026-10-28
NCT06242470
A Study of MGC026 in Participants With Advanced Solid Tumors
Trial Treatment · Phase 1 · MacroGenics
Oxford University Hospitals NHS Foundation Trust, Oxford · The Royal Marsden NHS Foundation Trust, Sutton
Registry updated 2026-10-28
NCT06345729
A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Royal Devon & Exeter Hospital-Oncology ( Site 2302), Exeter · Milton Keynes Hospital ( Site 2304), Milton Keynes
Registry updated 2026-10-26
NCT06942442
A Phase II Trial of Tebentafusp in HLA-A*02:01 Positive Patients With Advanced Clear Cell Sarcoma
Trial Treatment · Phase 2 · Sarcoma Alliance for Research through Collaboration
Royal Marsden, London
Registry updated 2026-10-26
NCT04031677
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
Trial Treatment · Phase 3 · European Organisation for Research and Treatment of Cancer - EORTC
University Hospitals Birmingham - Queen Elisabeth Medical Centre, Birmingham · NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital, Glasgow · Leeds Teaching Hospitals NHS Trust - St. James's University Hospital, Leeds · The Royal Marsden Hospital, London · Clatterbridge cancer center, Metropolitan Borough of Wirral · Newcastle Hospitals - Freeman Hospital, Northern Centre For Cancer Care, Newcastle · Nottingham University Hospitals NHS Trust - City Hospital, Nottingham · Oxford University Hospitals NHS Trust - Churchill Hospital, Oxford
Registry updated 2026-10-07
NCT06641908
Anti-GD2 ADC M3554 in Advanced Solid Tumors
Trial Treatment · Phase 1 · EMD Serono Research & Development Institute, Inc.
Royal Marsden Hospital-Sutton - Dept of Oncology (Surrey), Sutton
Registry updated 2026-10-07
NCT05944237
HTL0039732 in Participants With Advanced Solid Tumours
Trial Treatment · Phase 1/2 · Cancer Research UK
Addenbrooke's Hospital, Cambridge · Velindre Cancer Centre, Cardiff · Ninewells Hospital, Dundee · Clatterbridge Cancer Centre, Liverpool · Guy's Hospital, London · The Christie Hospital, Manchester
Registry updated 2026-10-01
NCT07602777
A Study Evaluating the Efficacy and Safety of Risvutatug Rezetecan in Participants With Advanced Sarcomas (EMBOLD Sarcoma-202)
Trial Treatment · Phase 1/2 · GlaxoSmithKline
GSK Investigational Site, London · GSK Investigational Site, Manchester
Registry updated 2026-10-01
NCT06881992
A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism
Trial Treatment · Phase 3 · Rezolute
Investigative Site, Saint Johns Wood · Investigative Site, Withington
Registry updated 2026-09-28
NCT06884618
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)
Trial Treatment · Phase 1 · Hoffmann-La Roche
New Queen Elizabeth Hospital Birmingham, Birmingham · St. Bartholomew's Hospital, London
Registry updated 2026-09-28
NCT04094610
A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations
Trial Treatment · Phase 1/2 · Turning Point Therapeutics, Inc.
Local Institution - 4403, Birmingham · University Hospital of Wales, Cardiff · Royal Hosp. for Children, Glasgow · Alder Hey Children's NHS Foundation Trust, Liverpool · The Royal Marsden NHS Foundation Trust, London · Great Ormond Street Hospital For Children NHS Foundation Trust, London
Registry updated 2026-09-25
NCT06797999
First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma
Trial Treatment · Phase 1/2 · Adcendo ApS
Royal Marsden, London
Registry updated 2026-09-11
NCT03715933
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
Trial Treatment · Phase 1 · Inhibrx Biosciences, Inc
University College London Hospital, London · The Royal Marsden NHS Foundation Trust, London · Great North Children's Hospital, London · Royal Manchester Children's Hospital, Manchester
Registry updated 2026-09-08
NCT07613723
A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid Malignancies
Trial Treatment · Phase 1 · Zelluna Immunotherapy AS
The Royal Marsden NHS Foundation Trust, London · The Christie NHS Foundation Trust, Manchester
Registry updated 2026-09-04
NCT07751380
Multi-modular Chimeric Antigen Receptor T Cells tarGeting B7-H3 in Children, Teenage & Young Adult Sarcoma
Trial Treatment · Phase 1 · University College, London
University College London Hospital, London · Great Ormond Street Hospital, London
Registry updated 2026-08-07
NCT06789172
A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors
Trial Treatment · Phase 1 · Epkin
The Beatson, Glasgow · Leicester Royal Infirmary, Leicester · University College London Hospital, London · The Christie, Manchester · Churchill Hospital, Oxford
Registry updated 2026-06-11
NCT03093116
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
Trial Treatment · Phase 1/2 · Turning Point Therapeutics, Inc.
Local Institution - 4402, London · Local Institution - 4404, London · Local Institution - 4401, London · Local Institution - 4403, Manchester · Local Institution - 4405, Sutton
Registry updated 2026-05-27
NCT06408441
The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)
Research · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
The Royal Marsden Hospital, London
Registry updated 2026-04-03
NCT03141021
Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors
Research · Washington University School of Medicine
Royal National Orthopedic Hospital, London
Registry updated 2026-03-09
NCT03016819
Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)
Trial Treatment · Phase 3 · Advenchen Laboratories, LLC
Royal Marsden Hospital, London
Registry updated 2026-02-25
NCT07432932
Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients
Research · Royal Marsden NHS Foundation Trust
The Royal Marsden Hospital, London
Registry updated 2026-02-25
NCT05111964
HIFU Ablation of Soft Tissue Sarcoma
Trial Treatment · Oxford University Hospitals NHS Trust
Churchill Hospital, Oxford
Registry updated 2026-02-04
NCT06988475
DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations
Trial Treatment · Phase 2/3 · Cancer Research UK
Belfast City Hospital, Belfast · University Hospital Birmingham, Birmingham · Bristol Haematology and Oncology Centre, Bristol · Addenbrooke's Hospital, Cambridge · Velindre Cancer Centre, Cardiff · Western General Hospital, Edinburgh · The Beatson Hospital, Glasgow · Leicester Royal Infirmary, Leicester · Guy's Hospital, London · University College London Hospital, London · The Christie Hospital, Manchester · Clatterbridge Cancer Centre, Metropolitan Borough of Wirral · Freeman Hospital, Newcastle · Churchill Hospital, Oxford · Western Park Hospital, Sheffield · Southampton General Hospital, Southampton · Royal Marsden Hospital, Sutton
Registry updated 2025-11-24
NCT07104955
Salutare One Referral Software Impact on Multi-Disciplinary Team (MDT) Meetings Effectiveness and Safety
Trial Treatment · Salutare Group Ltd.
Royal National Orthopaedic Hospital, London
Registry updated 2025-08-05

All Sarcoma trials and the map

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