Sickle cell disease: open trials in France

39 open trials have a site in France. Registry data; only the trial team decides who can take part.

NCT07224360
Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)
Trial Treatment · Phase 2 · CSL Behring
Centre Hospitalier Regional De Marseille, Marseille · Centre Hospitalier Universitaire de Nantes, Nantes · Centre Hospitalier Universitaire Rouen, Rouen Cedex · Oncopole Claudius Regaud, Toulouse
Registry updated 2026-11-03
NCT05777993
A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an Agios-Sponsored Mitapivat Study
Trial Treatment · Phase 4 · Agios Pharmaceuticals, Inc.
CHU de Bordeaux - Hôpital Pellegrin, Bordeau · CHU Hôpital Henri Mondor, Créteil · Hôpital Edouard Herriot - CHU de Lyon, Lyon · Hopitaux de La Timone, Marseille · Hopital Necker Enfants Malades, Paris · AP-HP Hopital Europeen Georges Pompidou, Paris
Registry updated 2026-10-28
NCT07656415
A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)
Trial Treatment · Phase 3 · Agios Pharmaceuticals, Inc.
Centre hospitalier Universitaire de Bordeaux, Bordeaux · Assistance Publique Hopitaux De Paris, Creteil · Hospital Edouard Herriot, Lyon Cedex 03 · Centre Hospitalier Regional De Marseille, Marseille
Registry updated 2026-10-28
NCT06147414
Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders
Research · Assistance Publique - Hôpitaux de Paris
Hôpital Cochin, Maternité Port-Royal, service de Gynécologie obstétrique, Paris
Registry updated 2026-10-21
NCT06975865
The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease
Trial Treatment · Phase 3 · Sanofi
Créteil · Marseille · Paris · Toulouse
Registry updated 2026-10-15
NCT06699849
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
Trial Treatment · Phase 2 · CSL Behring
Assistance Publique Hopitaux De Paris, Bobigny · Pellegrin Hospital, Bordeaux · Assistance Publique Hopitaux De Paris, Creteil · Hospices Civils De Lyon, Lyon Cedex 03 · Centre Hospitalier Universitaire de Nantes, Nantes · Centre Hospitalier Universitaire Rouen, Rouen Cedex
Registry updated 2026-10-08
NCT06578507
Pharmacokinetics, Efficacy and Safety of Twice Daily Dosing Regimen of Hydroxycarbamide Dispersible Tablets in Children With Sickle Cell Disease
Trial Treatment · Phase 2 · Theravia
Centre Hospitalier Intercommunal Créteil, Créteil · GHEF, Site de Marne-la-Vallée, Jossigny · Hopital Bicetre, Le Kremlin-Bicêtre · Institut d'hématologie et d'oncologie Pédiatrique iHOPE, Lyon · Hopital Necker Enfants Malades, Paris · CH Saint Denis, Saint-Denis
Registry updated 2026-10-01
NCT07852442
Comparison of Thrombin Generation, Platelet Activation and Aggregation Profiles in Patients With Sickle Cell Disease Depending on Their SS or SC Genotype (DrepAgreg)
Research · Centre Hospitalier Universitaire de la Guadeloupe
Hopital Avicenne, Bobigny
Registry updated 2026-10-01
2025-524464-38-00
A research study to evaluate how well etavopivat works in children with sickle cell disease
Trial Treatment · Phase 3 · Novo Nordisk A/S
Centre Hospitalier Universitaire de Dijon, Dijon · Centre Hospitalier Universitaire Grenoble Alpes, Grenoble Cedex 9 · Hopital Necker Enfants Malades, Paris · Robert Debre University Hospital, Paris
Registry updated 2026-09-28
NCT06198712
A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Disease
Trial Treatment · Phase 2 · Forma Therapeutics, Inc.
Hospices Civils de Lyon, Lyon · Assistance Publique Hopitaux de Paris, Paris · Centre Hospitalier Universitaire Rouen, Rouen Cedex
Registry updated 2026-09-18
NCT06609226
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
Trial Treatment · Phase 3 · Novo Nordisk A/S
Assistance Publique Hopitaux De Paris, Creteil · Hospices Civils De Lyon, Lyon Cedex 03 · Assistance Publique Hopitaux de Paris, Paris
Registry updated 2026-09-18
NCT06612268
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
Trial Treatment · Phase 3 · Novo Nordisk A/S
Assistance Publique Hopitaux De Paris, Bobigny · Centre hospitalier Universitaire de Bordeaux, Bordeaux · Assistance Publique Hopitaux De Paris, Creteil · Centre Hospitalier Universitaire Grenoble Alpes, Grenoble Cedex 9 · Hospices Civils De Lyon, Lyon Cedex 03 · Assistance Publique Hopitaux de Paris, Paris · Centre Hospitalier Universitaire Rouen, Rouen Cedex
Registry updated 2026-09-17
NCT07274254
Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell Disease
Trial Treatment · Phase 3 · Nantes University Hospital
CHU de Bordeaux, Hôpital Saint-André, Bordeaux · CHU Bordeaux, Bordeaux · CHU Lille, Lille · CHU La Timone, Marseille · CHU de Nantes, Nantes · CHU Orléans, Orléans · Hôpital Tenon - APHP, Paris · CHU Poitiers, Poitiers · CHU Rouen, Rouen · Oncopole Toulouse, Toulouse · CHRU Tours Hopital Bretonneau, Tours
Registry updated 2026-09-09
2024-518437-28-00
Lidocaine for opioid sparing in vaso-occlusive crisis of Sickle Cell Disease
Trial Treatment · Phase 3 · Centre Hospitalier Universitaire De Nantes
Centre hospitalier Universitaire de Bordeaux, Bordeaux · Centre Hospitalier Universitaire De La Guadeloupe, Les Abymes · Centre Hospitalier Universitaire De Lille, Lille Cedex · Hopital de la Timone, Marseille · Centre Hospitalier Universitaire de Nantes, Nantes · Centre Hospitalier Universitaire d'Orléans, ORLEANS · Hopital Tenon, Paris Cedex 20 · Centre Hospitalier Universitaire de Poitiers, Poitiers · Centre Hospitalier Universitaire Rouen, Rouen · Centre Hospitalier Universitaire De Bordeaux, Talence · IUCT-Oncopole, Toulouse Cedex 9 · Centre Hospitalier Régional Universitaire de Tours, Tours
Registry updated 2026-09-03
NCT05431088
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
Trial Treatment · Phase 2/3 · Pfizer
Hopital Avicenne, Bobigny Cedex · Hospital Edouard Herriot, Lyon · IUCT-Oncopole, Toulouse Cedex 9
Registry updated 2026-08-18
NCT06481306
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Trial Treatment · Phase 1/2 · Bristol-Myers Squibb
AP-HP Hopital Henri Mondor, Créteil · Hoptial La Timone, Marseille · Hopital Necker Enfants Malades, Paris · Les Hopitaux Universitaires de Strasbourg, Strasbourg · Institut de Cancérologie Strasbourg Europe, Strasbourg
Registry updated 2026-08-18
NCT07752043
Standard of Care Comparative Arm of Phase 1/2 Gene Therapy Trial DREPAMIR" in Severe Sickle Cell Disease Patients
Trial Treatment · Assistance Publique - Hôpitaux de Paris
Necker-Enfants Malades Hospital, Apheresis Unit, Paris
Registry updated 2026-08-07
2024-513750-30-00
Pharmacokinetics, Efficacy and Safety of Twice Daily Dosing Regimen of Hydroxycarbamide Dispersible Tablets in Children with Sickle Cell Disease: a single-group, non-randomised, open-label study (KID-BID)
Trial Treatment · Phase 2 · Theravia
Centre Hospitalier De Cayenne, Cayenne · Centre Hospitalier Intercommunal Creteil, Creteil Cedex · Hôpital Bicêtre APHP, Le Kremlin-Bicêtre · Grand Hopital de l'Est Francilien, Meaux · CEREDIH Groupe Hospitalier Necker-Enfants Malades, Paris Cedex 15 · Centre Hospitalier General De St Denis, St Denis Cedex
Registry updated 2026-07-24
NCT06818266
Efficacy and Safety of Tocilizumab for Acute Chest Syndrome Treatment in Patients With Sickle Cell Disease
Trial Treatment · Phase 3 · Assistance Publique - Hôpitaux de Paris
Assistance Publique Hopitaux De Paris, Bobigny Cedex · Assistance Publique Hopitaux De Paris, Colombes Cedex · Assistance Publique Hopitaux De Paris, Creteil · Centre Hospitalier Intercommunal Créteil, Créteil · Assistance Publique Hopitaux De Paris, Creteil Cedex · Assistance Publique Hopitaux De Paris, Le Kremlin-Bicetre · Hospices Civils De Lyon, Lyon Cedex 03 · Centre Hospitalier Regional De Marseille, Marseille · Assistance Publique Hopitaux de Paris, Paris · Hopital Necker Enfants Malades, Paris · Centre Hospitalier Universitaire Rouen, Rouen · Centre Hospitalier Universitaire Rouen, Rouen Cedex · Centre Hospitalier Universitaire De Toulouse, Toulouse Cedex 9
Registry updated 2026-06-24
NCT07639008
Epidemiology of Invasive Bacterial Infections in Children With Sickle Cell Disease in France Between 2020 and 2025
Research · Assistance Publique - Hôpitaux de Paris
Hôpital Victor Dupouy (CH Argenteuil), Argenteuil · CHI Robert Ballanger, Aulnay-sous-Bois · Hôpital Jean Verdier, Bondy · Hôpital Pellegrin - Hôpital des Enfants, Bordeaux · Hôpital Ambroise-Paré, Boulogne-Billancourt · Hôpital Saint Camille, Bry-sur-Marne · Hôpital NOVO, Cergy-Pontoise · Hopital Antoine Beclere, Clamart · CH Sud Francilien, Corbeil-Essonnes · Chi Creteil, Créteil · CH du Sud Seine et Marne, Fontainebleau · CH Gonesse, Gonesse · GHEF, Site de Marne-la-Vallée, Jossigny · Hopital Bicetre, Le Kremlin-Bicêtre · GHT Yvelines Nord, Mantes-la-Jolie · Hopital Nord AP-HM, Marseille · GHEF Site de Meaux, Meaux · GH Sud Ile-de-France, Melun · Ghi Le Raincy-Montfermeil, Montfermeil · CHU Nantes, Nantes · CH Rives de Seine, Site de Neuilly-sur-Seine, Neuilly-sur-Seine · CHU Lenval, Nice · Hôpital Paris-Saclay, Orsay · Hôpital Trousseau, Paris · Hopital Robert Debre, Paris · Hôpital Necker, Paris · CHI Poissy, Poissy · CH Rambouillet, Rambouillet · CH Saint-Denis - Hôpital Delafontaine, Saint-Denis · Hôpital André Mignot, Versailles · Hôpital Intercommunal Villeneuve-St-Georges, Villeneuve-Saint-Georges
Registry updated 2026-06-10
NCT04657822
Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study
Trial Treatment · Phase 4 · Novartis Pharmaceuticals
Hopital Necker Enfants Malades, Paris
Registry updated 2026-06-08
NCT07498309
Evaluation of the Efficacy of Iloprost in the Management of Vaso-occlusive Crises in Adult Patients With Sickle Cell Disease
Trial Treatment · Phase 3 · University Hospital, Rouen
Centre Hospitalier Universitaire Amiens Picardie, Amiens Cedex 1 · Centre Hospitalier Universitaire de Caen Normandie, Caen · Groupe Hospitalier Du Havre, Montivilliers · Centre Hospitalier Universitaire Rouen, Rouen · Centre Hospitalier Interciommunal Elbeuf, Louviers, Val de Reuil, Saint-Aubin-lès-Elbeuf
Registry updated 2026-03-27
NCT07246265
Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive Care
Trial Treatment · University Hospital, Tours
Henri Mondor, Créteil · CH Le Mans, Le Mans · CHU de Nantes, Nantes · CHU d'Orléans, Orléans · CHU de Rennes, Rennes · CHRU de Tours, Tours
Registry updated 2026-03-10
NCT07432867
Efficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA.
Trial Treatment · Phase 1/2 · Assistance Publique - Hôpitaux de Paris
Department of Biotherapy, Necker-Enfants Malades Hospital, Paris
Registry updated 2026-03-04
2023-504847-15-00
Intranasal Sufentanil for Analgesia of Severe Sickle Cell Vaso-occlusive Pain Crisis in the Pediatric Emergency Department
Trial Treatment · Phase 3 · Assistance Publique Hopitaux De Paris
Ctre Hospitalier Intercomm R Ballanger, Aulnays-Sous-Bois · Assistance Publique Hopitaux De Paris, Bondy · Assistance Publique Hopitaux De Paris, Boulogne-Billancourt · Centre Hospitalier De Cayenne, Cayenne · Hopital Antoine Beclere, Clamart · Assistance Publique Hopitaux De Paris, Colombes · Centre Hospitalier Sud Francilien, Corbeil-Essonnes · Centre Hospitalier Intercommunal Créteil, Créteil · Les Hopitaux De Chartres, Le Coudray · Assistance Publique Hopitaux De Paris, Le Kremlin-Bicetre · Centre Hospitalier Universitaire De Lille, Lille Cedex · Centre Hospitalier Universitaire de Nantes, Nantes · Centre Hospitalier de Saint-Denis, Saint-Denis
Registry updated 2025-12-22

All Sickle cell disease trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

Report an error