Sickle cell disease: open trials in United Kingdom

12 open trials have a site in United Kingdom. Registry data; only the trial team decides who can take part.

NCT07224360
Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)
Trial Treatment · Phase 2 · CSL Behring
Royal Liverpool University Hospital, Liverpool · Guy's Hospital, London · Hammersmith Hospital, Imperial College Healthcare NHS Trust, London · The Royal London Hospital, London · Central Middlesex Hospital, London · St George's University Hopsitals NHS Foundation Trust, London · Manchester Royal Infirmary, Manchester
Registry updated 2026-11-03
NCT05777993
A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an Agios-Sponsored Mitapivat Study
Trial Treatment · Phase 4 · Agios Pharmaceuticals, Inc.
Manchester Royal Infirmary, Manchester University NHS Foundation Trust,, Manchester
Registry updated 2026-10-28
NCT06975865
The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease
Trial Treatment · Phase 3 · Sanofi
London · London · Manchester
Registry updated 2026-10-15
NCT06699849
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
Trial Treatment · Phase 2 · CSL Behring
Royal Liverpool University Hospital, Liverpool · Guy's Hospital, London · University College London Hospitals NHS Trust, London
Registry updated 2026-10-08
NCT06198712
A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Disease
Trial Treatment · Phase 2 · Forma Therapeutics, Inc.
King's College Hospital - Alex Mowat Research Hub, London · Guys and St Thomas NHS Foundation Trust / Evelina Childrens Hospital, London · Manchester Royal Infirmary_1, Manchester
Registry updated 2026-09-18
NCT06609226
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
Trial Treatment · Phase 3 · Novo Nordisk A/S
Guy's Hospital, London · Kings College Hospital - Haematology, London · Imperial College London, London · King's College Hospital - Paediatric Research, London · Guy's Hospital - Haematology, London · Evelina London Children's Hospital - Haemophilia, London · Manchester Royal Infirmary, Manchester · Royal Hallamshire Hospital, Sheffield
Registry updated 2026-09-18
NCT06612268
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
Trial Treatment · Phase 3 · Novo Nordisk A/S
Addenbrooke's Hospital - Haemophilia and Thrombophilia, Cambridge · Whittington Hospital, London · Kings College Hospital - Haematology, London · Guy's Hospital - Haematology, London · King's College Hospital - Paediatric Research, London · Imperial College London, London
Registry updated 2026-09-17
NCT05431088
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
Trial Treatment · Phase 2/3 · Pfizer
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol · Bristol Royal Infirmary, Bristol · King's College Hospital NHS Foundation Trust, London · University College London Hospital, London · Guy's & St Thomas' NHS Foundation Trust, London · Hammersmith Hospital, London · Hammersmith Hospital, Imperial College Healthcare NHS Trust, London
Registry updated 2026-08-18
NCT06481306
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Trial Treatment · Phase 1/2 · Bristol-Myers Squibb
University Hospitals Sussex NHS Foundation Trust, East Sussex · Leeds · London · King's College Hospital, London · London
Registry updated 2026-08-18
NCT04208529
A Long-term Follow-up Study in Participants Who Received CTX001
Trial Treatment · Phase 3 · Vertex Pharmaceuticals Incorporated
University College London Hospital NHS Foundation - Main, London · Hammersmith Hospital - Haematology Dept, London · Great Ormond Street Hospital for Children, London
Registry updated 2026-08-11
NCT06923111
PASS of Xromi Comparing Safety and Effectiveness in Children Under 2 Years With Sickle Cell Disease [PRECISE PASS]
Research · Nova Laboratories Limited
Basildon University Hospital, Basildon · Noah's Ark Children's Hospital for Wales, Cardiff · University College London Hospital, London · Evelina London Children's Hospital, London · The Royal London Hospital, London · Kings College Hospital, London · Whittington Hospital, London · North Middlesex University Hospital, London · Royal Manchester Children's Hospital, Manchester · John Radcliffe Hospital, Oxford
Registry updated 2026-03-05
NCT05392894
RElated Haplo-DonoR Haematopoietic stEm Cell Transplantation for Adults With Severe Sickle Cell Disease
Trial Treatment · Phase 3 · King's College Hospital NHS Trust
King's College Hospital, London
Registry updated 2023-05-10

All Sickle cell disease trials and the map

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