Thyroid cancer: open trials in United Kingdom

• NCT05786924

  Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

  Trial Treatment · Phase 1/2 · Institut de Recherches Internationales Servier

  Hammersmith Hospital, London · University College London Hospital, London · The Christie NHS Foundation Trust, Manchester

  Registry updated 2026-10-13

• NCT07440290

  DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.

  Trial Treatment · Phase 2/3 · Cancer Research UK

  Belfast City Hospital, Belfast · Birmingham Children's Hospital, Birmingham · University Hospital Birmingham, Birmingham · Bristol Royal Hospital for Children, Bristol · Bristol Haematology and Oncology Centre, Bristol · Addenbrooke's Hospital, Cambridge · Cardiff Children's Hospital, Cardiff · Velindre Cancer Centre, Cardiff · Western General Hospital, Edinburgh · The Beatson Hospital, Glasgow · Royal Hospital for Children Glasgow, Glasgow · Leicester Royal Infirmary, Leicester · Alder Hey Hospital, Liverpool · Great Ormond Street Hospital, London · Guy's Hopsital, London · University College London Hospital, London · Royal Manchester Children's Hospital, Manchester · The Christie Hospital, Manchester · Clatterbridge Cancer Centre, Metropolitan Borough of Wirral · Great North Children's Hospital, Newcastle · Freeman Hospital, Newcastle · Churchill Hospital, Oxford · John Radcliffe Hospital, Oxford · Weston Park Hospital, Sheffield · Sheffield's Children's Hospital, Sheffield · Southampton General Hospital, Southampton · The Royal Marsden Hospital, Sutton

  Registry updated 2026-08-17

• NCT05503797

  A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

  Trial Treatment · Phase 2 · Fore Biotherapeutics

  Sarah Cannon Research Institute, London · The Christie NHS Foundation Trust, Manchester

  Registry updated 2026-07-27

• NCT03093116

  A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

  Trial Treatment · Phase 1/2 · Turning Point Therapeutics, Inc.

  London · London · London · Manchester · Sutton

  Registry updated 2026-05-27

• NCT05604963

  Hemithyroidectomy or Total-Thyroidectomy in 'Low-risk' Thyroid Cancers

  Trial Treatment · University College, London

  Royal United Hospital, Bath · Queen Elizabeth Hospital, Birmingham · University Hospitals Bristol and Weston NHS Foundation Trust, Bristol · Addenbrooke's Hospital, Cambridge · University Hospital of Wales, Cardiff · Colchester Hospital, Colchester · Leighton Hospital, Crewe · Royal Derby Hospital, Derby · Ninewells Hospital, Dundee · NHS Lothian, Edinburgh · Royal Devon and Exeter Hospital, Exeter · Forth Valley Royal Hospital, Falkirk · Medway Maritime Hospital, Gillingham · NHS Greater Glasgow & Clyde, Glasgow · Ipswich Hospital, Ipswich · Leicester Royal Infirmary, Leicester · Liverpool University Hospitals, Liverpool · Guy's Hospital, London · St. George's Hospital, London · University College London Hospital, London · The Royal Marsden Hospitals, London · Lister Hospital, London · Northwick Park Hospital, London · Luton and Dunstable University Hospital, Luton · Northampton General Hospital, Northampton · Norfolk and Norwich University Hospital, Norwich · Nottingham University Hospitals NHS Trust, Nottingham · Derriford Hospital, Plymouth · University Hospitals Dorset NHS Foundation Trust, Poole · Queen Alexandra Hospital, Portsmouth · Glan Clwyd Hospital (Betsi Cadwaladr University Health Board), Rhyl · Sheffield Teaching Hospitals, Sheffield · Musgrove Park Hospital, Taunton

  Registry updated 2026-03-05

• NCT05768178

  DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.

  Trial Treatment · Phase 2/3 · Cancer Research UK

  Belfast City Hospital, Belfast · University Hospital Birmingham, Birmingham · Bristol Haematology and Oncology Centre, Bristol · Addenbrooke's Hospital, Cambridge · Velindre Cancer Centre, Cardiff · Western General Hospital, Edinburgh · The Beatson Hospital, Glasgow · Leicester Royal Infirmary, Leicester · Guy's Hospital, London · University College London Hospital, London · The Christie Hospital, Manchester · Clatterbridge Cancer Centre, Metropolitan Borough of Wirral · Freeman Hospital, Newcastle · Churchill Hospital, Oxford · Weston Park Hospital, Sheffield · Southampton General Hospital, Southampton

  Registry updated 2025-11-24

• NCT03175224

  APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

  Trial Treatment · Phase 2 · Apollomics Inc.

  University College London Hospital, London · The Christie NHS Foundation Trust, Manchester · Royal Marsden Hospital - Surrey, Surrey Quays

  Registry updated 2025-06-27

• NCT06849284

  To Perform a Post-market Study of the Performance of the Idylla ThyroidPrint Assay Using Clinical Samples in Predicting the Nature of Indeterminate Thyroid Nodules (ITNs) Across Multiple Centers.

  Research · Royal Cornwall Hospitals Trust

  Royal Cornwall Hospital, Truro

  Registry updated 2025-06-04

• NCT05837260

  Investigating Utility of ctDNA and Tumour Evolution in Advanced Thyroid Cancer

  Research · Royal Marsden NHS Foundation Trust

  The Royal Marsden NHS Foundation Trust, London

  Registry updated 2024-08-09

All Thyroid cancer trials and the map

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