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What science says

What does science say about Statins and Stroke?

  • We don’t say yes or no. We show what has been studied.
  • Working in a lab or in animals does not mean it works in people.
  • Don’t stop or change your treatment without talking to your doctor.

What has been studied

  1. 1

    Lab studies (cells)

    Tests on cells in a dish.

    Source: PubMed · as of 4 Nov 2026 · Open the search at PubMed

    5

  2. 2

    Animal studies

    Tests in mice, rats or other animals.

    Source: PubMed · as of 4 Nov 2026 · Open the search at PubMed

    177

  3. 3

    Studies in people

    Published studies with human participants.

    Source: PubMed · as of 4 Nov 2026 · Open the search at PubMed

    1178

  4. 4

    Registered trials in people

    Trials entered in a public registry, whatever their result.

    ClinicalTrials.gov: 17 · as of 3 Nov 2026 · Open the search at ClinicalTrials.gov

    EU CTIS: 0 · as of 3 Nov 2026 · Open the search at EU CTIS

    By phase:No phase (6)Phase 4 (4)Phase 3 (4)Phase 2 (2)Phase 2/3 (1)

    By status:Recruiting (11)Not yet recruiting (3)Completed (2)By invitation only (1)

    Countries (6):China (8)Egypt (2)Taiwan (2)Brazil (1)Netherlands (1)United States (1)

    With a linked publication (results): 2 of 17

    The registries do not tell us here whether results were posted; a linked publication is shown instead.

    The trials
    • NCT07908875 Upfront Lipid-Lowering Therapy With Statins Combined With Hybutimibe in Patients With Acute Ischemic Stroke or Transient Ischemic Attack.
      Phase 3 · Not yet recruiting · ClinicalTrials.gov · 2026
    • NCT07344610 Effects of Short-term Intensive Statin Therapy on Lipid Levels
      No phase · Recruiting · ClinicalTrials.gov · 2026 · China
    • NCT07307989 Early Statin-Ezetimibe Combination vs. Statin Monotherapy in Stroke With Atherosclerosis
      Phase 2 · Recruiting · ClinicalTrials.gov · 2025 · Taiwan
    • NCT06785727 StAtins in Frail OldEr Patients with Ischemic Stroke or Transient Ischemic Attack - the Randomized Controlled Trial
      Phase 4 · Not yet recruiting · ClinicalTrials.gov · 2025
    • NCT07875335 Fufang Tongluo Decoction as an Adjunct to Aspirin and Atorvastatin for Ischemic Moyamoya Disease
      No phase · By invitation only · ClinicalTrials.gov · 2024 · China
    • NCT06785740 Statins in Frail Older Patients with Ischemic Stroke or Transient Ischemic Attack - the Prospective Cohort Study
      No phase · Recruiting · ClinicalTrials.gov · 2024 · Netherlands
    • NCT06604117 Efficacy of Probucol Combined with Statins Treatment for Ischemic Stroke
      No phase · Recruiting · ClinicalTrials.gov · 2024 · China
    • NCT06308952 Atorvastatin Pretreatment in Cerebrovascular Events (APICES) After Flow Diverter Implantation
      Phase 4 · Recruiting · ClinicalTrials.gov · 2024 · China
    • NCT06360120 Combining Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Large-vessel Ischemic Stroke
      Phase 3 · Recruiting · ClinicalTrials.gov · 2024 · Egypt
    • NCT06358313 Concomitant Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Small Vessel Stroke
      Phase 3 · Recruiting · ClinicalTrials.gov · 2024 · Egypt
    • NCT05589454 Intracranial Hemorrhage Risk of Intensive Statin in Acute Ischemic Stroke With Cerebral Microbleeds
      Phase 4 · Not yet recruiting · ClinicalTrials.gov · 2023 · China
    • NCT05155137 Polypill and RiscOMeter to Prevent StrOke and CogniTive ImpairmEnt (PROMOTE)
      Phase 3 · Recruiting · ClinicalTrials.gov · 2021 · Brazil
    • NCT04847752 Study of Predictive Factors Related to Prognosis of Patients With Ischemic Stroke Due to Large-artery Atherosclerosis
      No phase · Recruiting · ClinicalTrials.gov · 2021 · China
    • NCT06455488 MANAGE-VT Registry - MANAGEment of Ventricular Tachycardia Outcomes Registry
      No phase · Recruiting · ClinicalTrials.gov · 2020 · United States
    • NCT03753555 The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques
      Phase 4 · Recruiting · ClinicalTrials.gov · 2018 · China
    • NCT06696820 Efficacy and Safety of Early Combined Therapy With PCSK9 Inhibitors and Statins in Acute Ischemic Stroke
      Phase 2/3 · Completed · ClinicalTrials.gov · 2024 · China
    • NCT04824911 Statin and Dual Antiplatelet Therapy to Prevent Early Neurological Deterioration in Branch Atheromatous Disease
      Phase 2 · Completed · ClinicalTrials.gov · 2021 · Taiwan

    17

  5. 5

    Approved treatment

    Approved by a medicines regulator for this disease.

    No

Not medical advice. Talk to the care team before changing treatment. Thinking of paying for it? Read this first

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What does science say about Statins and Stroke?