Written from the studies on PubMed, searched on 11 Nov 2026. Every number below comes from a study listed under Sources.
What people read
Posts online say that Vitamin C (incl. high-dose) helps with Prostate cancer.
What has been studied
- 5In people3 randomised trials
- 15In animals
- 18Only in the lab
What the studies found
Vitamin C (incl. high-dose) has been tested in randomised trials in people with Prostate cancer.
We found 60 published papers on Vitamin C (incl. high-dose) and Prostate cancer. They were published between 1976 and 2026.
5 of them are studies in people (3 randomised trials), 6 are reviews, 15 are studies in animals and 18 are studies only in the lab.
The most important ones are listed under Sources.
What this means for you: A study in people is not proof that it helps you. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial.2024 · Cancer Res Commun · Randomised trial
- Effect of a nutritional supplement containing vitamin E, selenium, vitamin c and coenzyme Q10 on serum PSA in patients with hormonally untreated carcinoma of the prostate: a randomised placebo-controlled study.2005 · Eur Urol · Randomised trial
- Serum markers variation consistent with autoschizis induced by ascorbic acid-menadione in patients with prostate cancer.2003 · Med Oncol · Randomised trial
- Weekly ascorbic acid infusion in castration-resistant prostate cancer patients: a single-arm phase II trial.2017 · Transl Androl Urol · Study in people
- Elimination of ascorbic acid after high-dose infusion in prostate cancer patients: a pharmacokinetic evaluation.2015 · Basic Clin Pharmacol Toxicol · Study in people
- Relationship between Prostate Cancer and Benign Hyperplasia: Role of Inflammation-Induced Oxidative Stress, Vitamin C, and Epigenetics.2026 · World J Mens Health · Review
- Letter to the Editor: Comment on "The association between vitamin C and breast cancer, prostate cancer and colorectal cancer: A systematic review and meta-analysis".2025 · Clin Nutr ESPEN · Review
- The association between vitamin C and breast cancer, prostate cancer and colorectal cancer: A systematic review and meta-analysis.2025 · Clin Nutr ESPEN · Review
- Vitamin C Transporters and Their Implications in Carcinogenesis.2020 · Nutrients · Review
- Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658 Subjects.2015 · J Cancer · Review
- Evaluation of the in vitro and in vivo antitumor activities of vitamin C and K-3 combinations against human prostate cancer.2001 · J Nutr · Review
- PARP inhibition and pharmacological ascorbate demonstrate synergy in castration-resistant prostate cancer.2026 · Mol Oncol · In animals
- Reactivation of nucleases with peroxidation damages induced by a menadione: ascorbate combination devastates human prostate carcinomas: ultrastructural aspects.2024 · Ultrastruct Pathol · In animals
- PARP inhibition and pharmacological ascorbate demonstrate synergy in castration-resistant prostate cancer.2023 · bioRxiv · In animals
- Mitochondrial respiration inhibitor enhances the anti-tumor effect of high-dose ascorbic acid in castration-resistant prostate cancer.2023 · J Mol Med (Berl) · In animals
- Drug Repurposing of Pantoprazole and Vitamin C Targeting Tumor Microenvironment Conditions Improves Anticancer Effect in Metastatic Castration-Resistant Prostate Cancer.2021 · Front Oncol · In animals
- Increased Tumoral Microenvironmental pH Improves Cytotoxic Effect of Pharmacologic Ascorbic Acid in Castration-Resistant Prostate Cancer Cells.2020 · Front Pharmacol · In animals
- Effects of hypoxia and iron on ascorbic acid-mediated cytotoxicity in prostate cancer cell lines.2025 · Toxicol Appl Pharmacol · In the lab
- RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells.2017 · Cancer Res · In the lab
- Synergistic antitumor cytotoxic actions of ascorbate and menadione on human prostate (DU145) cancer cells in vitro: nucleus and other injuries preceding cell death by autoschizis.2014 · Ultrastruct Pathol · In the lab
- Exploration of effects of emodin in selected cancer cell lines: enhanced growth inhibition by ascorbic acid and regulation of LRP1 and AR under hypoxia-like conditions.2014 · J Appl Toxicol · In the lab
- Epigenetic DNA modifications and vitamin C in prostate cancer and benign prostatic hyperplasia: Exploring similarities, disparities, and pathogenic implications.2024 · Neoplasia · Other paper
- Intracellular ascorbate is a safe-guard and/or reservoir for plasma vitamin C in prostate cancer patients undergoing radiotherapy.2024 · Free Radic Biol Med · Other paper
- New perspectives of quercetin and vitamin C effects on fibronectin-binding integrins and chemokine receptors in prostate cancer cell lines.2021 · Bratisl Lek Listy · Other paper
- Assessment of early oxidative stress following the use of radiotheranostics agents 177Lu-PSMA for prostate cancer and 177Lu-DOTATATE for neuroendocrine tumors; radioprotective effect of vitamin C.2021 · Nucl Med Commun · Other paper