Omega-3 fatty acids (fish oil) & Endometriosis

Written from the studies on PubMed, searched on 11 Nov 2026. Every number below comes from a study listed under Sources.

What people read

Posts online say that Omega-3 fatty acids (fish oil) helps with Endometriosis.

What has been studied

• 1In people1 randomised trial
• 7In animals
• 2Only in the lab

What the studies found

!Omega-3 fatty acids (fish oil) has been tested in randomised trials in people with Endometriosis.

We found 16 published papers on Omega-3 fatty acids (fish oil) and Endometriosis. They were published between 1988 and 2026.

1 of them are studies in people (1 randomised trials), 2 are reviews, 7 are studies in animals and 2 are studies only in the lab.

The most important ones are listed under Sources.

Sources

1. A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1).2020 · PLoS One · Randomised trial
2. Effect of omega-3 polyunsaturated fatty acid on endometriosis.2025 · Clinics (Sao Paulo) · Review
3. The effect of two anti-inflammatory dietary components, omega-3 and resveratrol, on endometriosis.2024 · Ginekol Pol · Review
4. Efficacies of vitamin D and omega-3 polyunsaturated fatty acids on experimental endometriosis.2016 · Taiwan J Obstet Gynecol · In animals
5. The anti-inflammatory impact of omega-3 polyunsaturated Fatty acids during the establishment of endometriosis-like lesions.2014 · Am J Reprod Immunol · In animals
6. Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models.2013 · PLoS One · In animals
7. Dietary fish oil supplementation inhibits formation of endometriosis-associated adhesions in a chimeric mouse model.2013 · Fertil Steril · In animals
8. Oral eicosapentaenoic acid supplementation as possible therapy for endometriosis.2008 · Fertil Steril · In animals
9. [Effect of dietary supplementation with eicosapentaenoic acid on surgically induced endometriosis in the rabbit].1992 · Nihon Sanka Fujinka Gakkai Zasshi · In animals
10. Omega-3 fatty acids and L-carnitine prevent meiotic oocyte damage induced by follicular fluid from infertile women with endometriosis: an experimental study.2023 · JBRA Assist Reprod · In the lab
11. High omega-3:omega-6 fatty acid ratios in culture medium reduce endometrial-cell survival in combined endometrial gland and stromal cell cultures from women with and without endometriosis.2001 · Fertil Steril · In the lab
12. Omega-3 polyunsaturated fatty acid intake and pain, inflammatory cytokines, and quality of life in endometriosis.2026 · Front Nutr · Other paper
13. Correction: A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1).2020 · PLoS One · Other paper
14. Differences in omega-3 and fatty acid profiles between patients with endometriosis and those with a functional ovarian cyst.2013 · J Obstet Gynaecol · Other paper
15. Evaluation of the relationship between endometriosis and omega-3 and omega-6 polyunsaturated fatty acids.2012 · Iran Biomed J · Other paper

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