Written from the studies on PubMed, searched on 11 Nov 2026. Every number below comes from a study listed under Sources.
What people read
Posts online say that Omega-3 fatty acids (fish oil) helps with Fatty liver disease (MASLD/MASH).
What has been studied
- 36In people33 randomised trials
- 59In animals
- 1Only in the lab
What the studies found
Omega-3 fatty acids (fish oil) has been tested in randomised trials in people with Fatty liver disease (MASLD/MASH).
We found 164 published papers on Omega-3 fatty acids (fish oil) and Fatty liver disease (MASLD/MASH). They were published between 2004 and 2026.
36 of them are studies in people (33 randomised trials), 40 are reviews, 59 are studies in animals and 1 are studies only in the lab.
The most important ones are listed under Sources.
What this means for you: A study in people is not proof that it helps you. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- Effectiveness of nutrition education program and omega-3 supplementation on body weight, liver enzyme, lipid profile among non-alcoholic fatty liver disease patients.2026 · BMC Nutr · Randomised trial
- The effect of vitamin E and docosahexaenoic acid ethyl ester on Metabolic Dysfunction-Associated steatotic Liver Disease (MASLD)-A randomised, double-blind, placebo-controlled, parallel-group clinical trial (PUVENAFLD).2024 · Aliment Pharmacol Ther · Randomised trial
- Effects of dietary supplementation of fish oil plus vitamin D3 on gut microbiota and fecal metabolites, and their correlation with nonalcoholic fatty liver disease risk factors: a randomized controlled trial.2024 · Food Funct · Randomised trial
- Effect of fish oil supplementation on the concentration of miRNA-122, FGF-21 and liver fibrosis in patients with NAFLD: Study protocol for a randomized, double-blind and placebo-controlled clinical trial.2023 · Clin Nutr ESPEN · Randomised trial
- Elevated serum phosphatidylcholine (16:1/22:6) levels promoted by fish oil and vitamin D3 are highly correlated with biomarkers of non-alcoholic fatty liver disease in Chinese subjects.2022 · Food Funct · Randomised trial
- Concentrated fish oil ameliorates non-alcoholic fatty liver disease by regulating fibroblast growth factor 21-adiponectin axis.2022 · Nutrition · Randomised trial
- Efficacy of omega-3-rich Camelina sativa on the metabolic and clinical markers in nonalcoholic fatty liver disease: a randomized, controlled trial.2022 · Eur J Gastroenterol Hepatol · Randomised trial
- Effect of Omega-3 Polyunsaturated Fatty Acids on Lipid Metabolism in Patients With Metabolic Syndrome and NAFLD.2022 · Hepatol Commun · Randomised trial
- The effects of fish oil plus vitamin D3 intervention on non-alcoholic fatty liver disease: a randomized controlled trial.2022 · Eur J Nutr · Study in people
- Omega-3 mechanism of action in inflammation and endoplasmic reticulum stress in mononuclear cells from overweight non-alcoholic fatty liver disease participants: study protocol for the "Brazilian Omega Study" (BROS)-a randomized controlled trial.2021 · Trials · Study in people
- The Impact of Omega-3 Fatty Acids on Triglyceride Levels in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: A Meta-Analysis of Randomized Controlled Trials with Subgroup Analysis by Diabetes Status.2026 · Diabetes Metab Syndr Obes · Review
- Omega-3 polyunsaturated fatty acids and nonalcoholic fatty liver disease in adults: A meta-analysis of randomized controlled trials.2025 · Clin Nutr · Review
- Efficacy of fish oil supplementation on metabolic dysfunction-associated steatotic liver disease: a meta-analysis.2025 · Front Nutr · Review
- Effectiveness of Omega-3 Polyunsaturated Fatty Acids in Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.2024 · Cureus · Review
- Influence of Lipid Class Used for Omega-3 Fatty Acid Supplementation on Liver Fat Accumulation in MASLD.2024 · Physiol Res · Review
- A systematic review and meta-analysis of randomized controlled trials to evaluate plant-based omega-3 polyunsaturated fatty acids in nonalcoholic fatty liver disease patient biomarkers and parameters.2024 · Nutr Rev · Review
- Omega-3 fatty acids improve lipid metabolism by regulating miR-34a.2026 · Sci Rep · In animals
- NRF1 is upregulated by docosahexaenoic acid to ameliorate MASH through the inhibition of ER stress.2026 · Cell Death Dis · In animals
- Erucic acid, eicosapentaenoic acid, and docosahexaenoic acid consumption affect hepatic steatosis in mice fed a western diet.2026 · J Nutr Biochem · In animals
- Effects of Dietary Adjustment and Fish Oil on Lipid Metabolism, Inflammation, and Serum LPS in Non-Alcoholic Fatty Liver Disease.2025 · Bull Exp Biol Med · In animals
- Dietary Omega-3 Fatty Acids from Fish and Risk of Metabolic Dysfunction-Associated Steatotic Liver Disease in a Mediterranean Population: Findings from the NUTRIHEP Cohort.2025 · Nutrients · In animals
- Fishing for Solutions: How Pre-Conceptional Fish Oil Supplementation in Obese Fathers Reduces Risk of Non-Alcoholic Fatty Liver Disease in Offspring Mice.2025 · Mol Nutr Food Res · In animals
- Fish oil and chicoric acid combination protects better against palmitate-induced lipid accumulation via regulating AMPK-mediated SREBP-1/FAS and PPARα/UCP2 pathways.2023 · Arch Physiol Biochem · In the lab
- Long-chain omega-3-enriched erythrocyte fatty acid pattern is associated with lower odds of obesity and metabolic dysfunction-associated steatotic liver disease.2026 · Nutr J · Other paper
- Association of fish oil supplementation with risk of incident severe non-alcoholic fatty liver disease: a prospective study of 488 888 individuals.2026 · Food Funct · Other paper
- Moderate dietary intake of omega-3 polyunsaturated fatty acids is associated with reduced all-cause mortality in metabolic dysfunction-associated steatotic liver disease.2026 · Nutr Res · Other paper
- Selenium Ameliorated Oxidized Fish Oil-Induced Lipotoxicity via the Inhibition of Mitochondrial Oxidative Stress, Remodeling of Usp4-Mediated Deubiquitination, and Stabilization of Pparα.2024 · Antioxid Redox Signal · Other paper
