Stem cell treatment & Alzheimer disease

Written based on 23 research studies on PubMed, searched on 11 Nov 2026.

The claim

Posts online say that stem cell treatment helps with Alzheimer disease.

Where research stands

We found 85 published papers on stem cell treatment and Alzheimer disease. They were published between 2012 and 2026. 3 of them are studies in people. 1 of them compared people who got it with a group that did not. 38 were studies in animals, and 13 were only in cells in the lab. 25 papers are reviews that sum up other studies. 14 new studies in people are running or will start soon, say the trial registers. 99 research projects on stem cell treatment for Alzheimer disease are funded and still running.

• 3In people1 with a comparison group
• 38In animals
• 13Only in the lab

What the studies found

We have not summed up these studies in words yet. The most important papers are listed under Sources.

Verdict

Sources

1. Intracerebroventricular human mesenchymal stem cells induce MMP9-driven transient inflammation in Alzheimer's disease.2026 · Stem Cell Res Ther · Randomised trial
2. Therapeutic Efficacy of Autologous Blood-Derived Stem Cells with Growth Factors in Moderate to Severe Alzheimer's Disease: A Clinical Trial.2025 · Mol Neurobiol · Study in people
3. Mesenchymal Stem Cells With Adjuvant Dexamethasone in Patients With Alzheimer's Disease: A Phase IIa Trial.2025 · Dement Neurocogn Disord · Study in people
4. Stem cells and derived growth factors in Alzheimer's disease: mechanistic insights and translational perspectives.2026 · Inflammopharmacology · Review
5. The Therapeutic Potential of MicroRNAs Delivered By Mesenchymal Stem Cells in Parkinson's Disease, Alzheimer's Disease, and Stroke: A Systematic Review of Preclinical Studies.2026 · Mol Neurobiol · Review
6. Mesenchymal Stem Cell-Derived Exosomes for Alzheimer's Disease: Mechanisms, Preclinical Evidence, and Translational Challenges.2026 · Mol Neurobiol · Review
7. Human Stem Cell-Derived Models of the Alzheimer's Disease Neuroimmune System.2026 · Int J Mol Sci · Review
8. Advances in the clinical application of mesenchymal stem cells for neurological disorders.2026 · Stem Cell Res Ther · Review
9. Efficacy and Safety of Mesenchymal Stem Cell Therapy for Alzheimer's Disease: A Systematic Review and Meta-Analysis.2026 · Stem Cells Dev · Review
10. Evaluation of the effect of p38γ gene delivery using exosomes derived from mesenchymal stem cells on Alzheimer's rat model.2026 · Mol Biol Rep · In animals
11. Behavioral, biochemical, histological, and electrophysiological changes following intracerebral injection of bone marrow stem cell-derived exosomes in male rat models of Alzheimer's disease.2026 · Exp Brain Res · In animals
12. Intrathecal Transplantation of Human Umbilical Cord-Derived MSCs Outperforms Intravenous Administration in Attenuating Pathology and Cognitive Deficits in Alzheimer's Disease Mice.2026 · CNS Neurosci Ther · In animals
13. High-intensity interval training versus mesenchymal stem cells in amyloid-β-induced Alzheimer's disease: comparative effects on cognitive function,hippocampal inflammation, oxidative balance, and BDNF.2026 · Biochem Biophys Res Commun · In animals
14. Human Stem Cell Transplantation, Immunosuppression, and Noninvasive In vivo Cell Tracking in the Mouse Brain.2026 · Curr Protoc · In animals
15. miR155, triplicated in Down syndrome, regulates the development of neural stem cells and GABAergic interneurons in Alzheimer's disease mouse and human iPSC models.2026 · Alzheimers Dement · In animals
16. Generation of a human induced pluripotent stem cell line (HEBHMUi019-A) from a 67-year-old male Alzheimer's patient with APOE-ε4/ε4 genotype.2026 · Stem Cell Res · In the lab
17. Inhibition of Moesin and CD44 in stem cell-derived neurons affects the pathological genetic signature associated with Alzheimer's disease.2026 · Alzheimers Dement · In the lab
18. APOE4 Alters Early Transcriptional Programs and Inflammatory Signaling in Human Induced Pluripotent Stem Cells.2026 · Int J Mol Sci · In the lab
19. Methodology for human-induced pluripotent stem cell-derived excitatory and inhibitory neuron coculture with astrocytes for Alzheimer's disease modelling.2026 · Brain Commun · In the lab
20. Retraction: MicroRNA Let-7f-5p Promotes Bone Marrow Mesenchymal Stem Cells Survival by Targeting Caspase-3 in Alzheimer Disease Model.2026 · Front Neurosci · Other paper
21. RETRACTION: A Severe Alzheimer's Disease Patient Improved by Intravenous Mesenchymal Stem Cell Transplant.2026 · Case Rep Neurol Med · Other paper
22. Investigating the Potential of Gene Editing Technologies in Enhancing Stem Cell Therapy for Alzheimer's Disease.2026 · Curr Aging Sci · Other paper
23. Retraction notice to "Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation" [Stem Cell Res. 79 (2024) 103495].2026 · Stem Cell Res · Other paper